Korrosionsprodukte und deren Volumenfaktor bei der Korrosion von Stahl in Beton

Korrosion der Bewehrung ist eine der Hauptursachen für Schäden an Betonbauwerken. Das Volumen des Rostes ist i. d. R. um ein Vielfaches größer als das ursprüngliche Stahlvolumen, was zu Rissbildungen und Abplatzungen des Betons bis hin zum Verlust der Gebrauchstauglichkeit führen kann. Basierend auf gezielten Korrosionsuntersuchungen werden in diesem Beitrag die Hauptkomponenten der typischen Eisenoxide und ‐hydrate sowie deren Volumenfaktoren beschrieben, die als Basis für weiterführende Betrachtungen der Auswirkungen der Bewehrungskorrosion dienen sollen. Corrosion Products and their Volume Factor Created by Corrosion of Steel in Concrete Steel corrosion is one of the main reasons of degradation and damage of concrete structures. The volume of rust, resulting from steel corrosion, can be several times greater than the original steel volume which leads to cracking and spalling of the concrete and may finally end in the loss of structural functionality. Based on corrosion experiments on black steel, this article presents the major components of typical oxide layers and their volume expansion and thus forms a basis for further studies on corrosion of steel in concrete.     

On the physics of power,energy and economics of renewable electric energy sources - Part II

Renewable Energy Technologies (RETs) are often recognized as less competitive than traditional electric energy conversion systems. Obstacles with renewable electric energy conversion systems are often referred to the intermittency of the energy sources [1] and the relatively high maintenance cost. However, due to an intensified discourse on climate change and its effects, it has from a societal point of view, become more desirable to adopt and install CO₂ neutral power plants. Even if this has increased the competitiveness of RETs in a political sense, the new goals for RET installations must also be met with economical viability. We propose that the direction of technical development, as well as the chosen technology in new installations, should not primarily be determined by policies, but by the basic physical properties of the energy source and the associated potential for inexpensive energy production. This potential is the basic entity that drives the payback of the investment of a specific RET power plant. With regard to this, we argue that the total electric energy conversion system must be considered if effective power production is to be achieved, with focus on the possible number of full loading hours and the Degree of Utilization [2]. This will increase the cost efficiency and economical competitiveness of RET investments, and could enhance faster diffusion of new innovations and installations without over-optimistic subsidies. This paper elaborates on the overall problem of the economy of renewable electric energy conversion systems by studying the interface between physics, engineering and economy reported for RET power plants in different scientific publications. The core objective is to show the practical use of the Degree of Utilization and how the concept is crucial for the design and economical optimization disregarding subsidies. The results clearly indicate that the future political regulative frameworks should consider the choice of renewable energy source since this strongly affects the economical output from the RET power plants.     

Spectroscopic and in vitro Investigations of Fe2+/α-Ketoglutarate-Dependent Enzymes Involved in Nucleic Acid Repair and Modification

The activation of molecular oxygen for the highly selective functionalization and repair of DNA and RNA nucleobases is achieved by α-ketoglutarate (α-KG)/iron-dependent dioxygenases. Of special interest are the human homologues AlkBH of Escherichia coli EcAlkB and ten-eleven translocation (TET) enzymes. These enzymes are involved in demethylation or dealkylation of DNA and RNA, although additional physiological functions are continuously being found. Given their importance, studying enzyme-substrate interactions, turnover and kinetic parameters is pivotal for the understanding of the mode of action of these enzymes. Diverse analytical methods, including X-ray crystallography, UV/Vis absorption, electron paramagnetic resonance (EPR), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy have been employed to study the changes in the active site and the overall enzyme structure upon substrate, cofactor, and inhibitor addition. Several methods are now available to assess the activity of these enzymes. By discussing limitations and possibilities of these techniques for EcAlkB, AlkBH and TET we aim to give a comprehensive synopsis from a bioinorganic point-of-view, addressing researchers from different disciplines working in the highly interdisciplinary and rapidly evolving field of epigenetic processes and DNA/RNA repair and modification.     

Towards All-Solid-State Polymer Batteries: Going Beyond PEO with Hybrid Concepts

To go beyond polyethylene oxide in lithium metal batteries, a hybrid polymer/oligomer cell design is presented, where an ester oligomer provides high ionic conductivity of 0.2 mS cm⁻¹ at 40 °C within thicker composite cathodes with active mass loadings of up to 11 mg cm⁻² (LiNbO₃-coated) LiNi_0.6Mn_0.2Co_0.2 (NMC622), while a 30 µm thin scaffold-supported polymer electrolyte affords mechanical stability. Corresponding discharge capacities of the hybrid cells exceed 170 mAh g⁻¹ (11 mg cm⁻²) or 160 mAh g⁻¹ (6 mg cm⁻²) at rates of either 0.1 or 0.25 C. Multilayer pouch cells are projected to enable energy densities of 235 Wh L⁻¹ (6 mg cm⁻²) and even up to 356 Wh L⁻¹ (11 mg cm⁻²), clearly superior to other reported polymer-based cell designs. Polyester electrolytes are environmentally benign and safer compared to common liquid electrolytes, while the straightforward synthesis and affordability of precursors render hybrid polyester electrolytes suitable candidates for future application in solid-state lithium metal batteries.     

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis

A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on the involvement of ADAM10 and ADAM17 in retinoblastoma (RB), the most common malignant intraocular childhood tumor. A significant correlation between ADAM17 expression levels and RB laterality and RB staging was observed. Levels of ADAM10 or ADAM17 regulating miRNAs miR-145, -152, and -365 were significantly downregulated in RB cell lines, and reduced miR levels with simultaneously upregulated ADAM10 and ADAM17 expression were found in RB patients. The involvement of both ADAMs analyzed in ectodomain shedding of the neuronal cell adhesion molecule L1 (L1CAM), shown to induce pro-tumorigenic effects in RB, was confirmed. Lentiviral ADAM10 and ADAM17 single or ADAM10/17 double knockdown (KD) induced caspase-dependent apoptosis and reduced cell viability, proliferation, growth, and colony formation capacity of RB cells. Moreover, differential phosphorylation of the serine/threonine kinase AKT was observed following ADAM17 KD in RB cells. Chicken chorioallantoic membrane (CAM) assays revealed that ADAM17 and ADAM10/17 depletion decreases the tumorigenic and migration potential of RB cells in vivo. Thus, ADAMs are potential novel targets for future therapeutic RB approaches.     

Rosalind Picard: Affective Computing

User Modeling and User-Adapted Interaction -