A numerical study of mixing in a microchannel with circular mixing chambers

The mixing of fluids in a microchannel is numerically investigated using three-dimensional Navier–Stokes equations. The microchannel has circular mixing chambers that are designed to create a self-circulating flow that operates at low Reynolds numbers. The investigations have been performed on a design that comprises of four circular mixing chambers that are joined together with constriction channels. The study has been carried out in two parts. Firstly, the mixing and the flow field are analyzed for a wide range (1–250) of the Reynolds number. Secondly, the effects of two design parameters, namely, the ratio, w/d, of the width of the constriction channel to the diameter of the circular chamber, and the angle, θ, between the outer walls of the chamber and the connection channel, on the mixing and the flow field have been evaluated. The mixing has been evaluated using a parameter, called mixing index, which is based on the variance of the mass fraction. The mixing index at the end of the device increases rapidly with the Reynolds number. The presence of a flow recirculation zone in the circular chamber is found to be effective in enhancing mixing, especially for larger Reynolds numbers. The mixing performance improves with an increase in θ, and with a decrease in w/d. The characteristics of the pressure drop have also been investigated as a function of the Reynolds number and geometric parameters. © 2009 American Institute of Chemical Engineers AIChE J, 2009     

Derivation of a Retinoid X Receptor Scaffold from Peroxisome Proliferator‐Activated Receptor γ Ligand 1‐Di(1H‐indol‐3‐yl)methyl‐4‐trifluoromethylbenzene

PPARγ agonist DIM‐Ph‐4‐CF ₃ , a template for RXRα agonist (E)‐3‐[5‐di(1‐methyl‐1H‐indol‐3‐yl)methyl‐2‐thienyl] acrylic acid: DIM‐Ph‐CF₃ is reported to inhibit cancer growth independent of PPARγ and to interact with NR4A1. As both receptors dimerize with RXR, and natural PPARγ ligands activate RXR, DIM‐Ph‐4‐CF₃ was investigated as an RXR ligand. It displaces 9‐cis‐retinoic acid from RXRα but does not activate RXRα. Structure‐based direct design led to an RXRα agonist.

     

Biodiesel production from Cannabis sativa oil from Pakistan

The present study was appraised using response surface methodology for process optimization owing to strong interaction of reaction variables: NaOCH₃ catalyst concentration (0.25–1.50%), methanol/oil molar ratio (3:1–9:1), reaction time (30–90 min), and reaction temperature (45–65°C). The quadratic polynomial equation was determined using response surface methodology for predicting optimum methyl esters yield from Cannabis sativa oil. The analysis of variance results indicated that molar ratio and reaction temperature were the key factors that appreciably influence the yield of Cannabis sativa oil methyl esters. The significant (p < 0.0001) variable interaction between molar ratio × catalyst concentration and reaction time × molar ratio was observed, which mostly affect the Cannabis sativa oil methyl esters yield. The optimum Cannabis sativa oil methyl esters yield, i.e., 86.01% was gained at 53°C reaction temperature, 7.5:1 methanol/oil molar ratio, 65 min reaction time, and 0.80% catalyst concentration. The results depicted a linear relationship between observed and predicted values. The residual analysis predicted the appropriateness of the central composite design. The Cannabis sativa oil methyl esters, analyzed by gas chromatography, elucidated six fatty acid methyl esters (linoleic, α-linolenic, oleic, palmitic, stearic, and γ-linolenic acids). In addition, the fuel properties, such as kinematic viscosity at 40°C; cetane number; acid value; flash point; cloud, pour, and cold filter plugging points; ash content; density; and sulphur content, of Cannabis sativa oil methyl esters were evaluated and discussed with reference to ASTM D 6751 and EU 14214 biodiesel specifications.     

Hotspot management using a hybrid heat sink with stepped pin-fins

A hybrid heat sink design with microchannels and stepped pin-fins is introduced for the hotspot-targeted thermal management of microprocessors. The thermal and hydraulic performance were assessed numerically and compared to that of a hybrid heat sink with uniform pin-fins. Both hybrid heat sinks were designed to have two zones using rectangular microchannels above the processor’s background area and an array of pin-fins (stepped and uniform pin-fins) over the hotspot area. Conjugate heat transfer analysis was performed with the entire heat sink as the computational domain by solving the three-dimensional Navier-Stokes and energy equations. The hybrid heat sink with stepped pin-fins exhibited remarkable improvement in the temperature uniformity at the hotspot as compared to the one with uniform pin-fins, along with ample improvements in the thermal resistance, maximum temperature rise at the hotspot, and pumping power. A parametric investigation was also performed for the hybrid heat sink with uniform pin-fins to find an optimum geometry based on two geometric parameters: the ratio of the diameter of the pin-fins to their pitch and the total number of pin-fins in the array. The results revealed improvements in the thermal performance, but the pumping power was increased.     

The evaluation of the diffuse interface method for phase change simulations using OpenFOAM

In the present study, a new solver named phaseChangeHeatFoam is implemented on the OpenFOAM cfd package to simulate boiling and condensation. The solver is capturing the interface between two immiscible phases with a color function volume of fluid (CF‐VOF) method. The two fluids (vapor and liquid) are assumed Newtonian and incompressible. The surface tension is modeled with continuous surface force (CSF) which is improved with a Lafaurie filter to suppress the spurious current. The mass flux across the interface in the phase change process is determined by either Lee or Tanasawa mass transfer models. Additionally, the slight variation of saturation temperature with local pressure is considered with the simplified Clausius–Clapeyron relation. The coupled velocity pressure equation is solved using the PIMPLE algorithm. The new solver is validated and examined with (i) Stefan problem, (ii) two‐dimensional film boiling, (iii) the film condensation on a horizontal plate, (iv) the laminar film condensation over a vertical plate, and (v) bubble condensation in subcooled boiling. The present study shows the capability of a diffuse interface method in accurate simulation of the phase change process and it is expected to be instructive for further numerical studies in this area.     

Thermal Buckling Analysis of Multi-Walled Carbon Nanotubes Through a Nonlocal Shell Theory Incorporating Interatomic Potentials

Described in the current study is the thermal buckling behavior of multi-walled carbon nanotubes (WCNTs) via a nonlocal atomistic-based shell model. The model including the effects of small-scale length and the van der Waals (vdW) forces between adjacent nanotubes is established through the incorporation of the interatomic potential into the nonlocal Flügge shell theory. This model links the strain energy density induced in the continuum to Eringen's nonlocal constitutive relations. The set of coupled field equations are analytically solved for two types of temperature distribution. The present model is of a distinguishing feature which is its independence from the widely scattered values of Young's modulus and the effective wall thickness of carbon nanotubes.     

Simulating the effect of subsurface stresses and transient pore pressure on wellbore stability in subsea horizontal wells

The most prominent challenge associated with offshore horizontal drilling is wellbore stability. In this paper, simulation of in-situ stresses around the wellbore is conducted to study the effects of transient pore pressure on the stability of horizontal wells. The rock mechanical analysis based on finite element technique lead to investigate a unique behavior found in subsea horizontal wells known as transient pore pressure behavior and near wellbore pressure gradients. The results demonstrate that near wellbore pore pressure gradient is only active in rock formations which possess transient pore pressure behavior; therefore, simulated solutions require adjustment to achieve accurate results.     

Design development and testing of a solar PV pump based drip system for orchards

A Solar Photovoltaic (PV) pump operated drip irrigation system has been designed and developed for growing orchards in arid region considering different design parameters like pumps size, water requirements, the diurnal variation in the pressure of the pump due to change in irradiance and pressure compensation in the drippers. The system comprising a PV pump with 900 W_p PV array and 800 W dc motor-pump mono-block, micro filter, main and sub-mains and three open-able low-pressure compensating drippers on each plant was field tested. The emission uniformity was observed to be 92–94% with discharge of 3.8 l/h in the pressure range of 70–100 kPa provided by the pump and thus the system could irrigate some 1 ha area within 2 h. Based on the performance of the PV pump and the drip system, it was inferred that about 5 ha area of orchard could be covered. The projected benefit–cost ratio for growing pomegranate orchards with such a system was evaluated to be above 2 even with the costly PV pump and therefore the system was considered to be an appropriate technology for the development of arid region.     

The fatty acids of wax esters and sterol esters from vernix caseosa and from human skin surface lipid

Separation of sterol esters from wax esters in the lipids of vernix caseosa and adult human skin surface was accomplished by column chromatography on MgO. The fatty acids of the sterol esters and wax esters of both samples were separated into saturates and monoenes, and examined in detail by gas liquid chromatography (GLC). The saturated fatty acids of the wax esters of vernix caseosa and of adult human skin surface were remarkably similar. They ranged in chain length from at least C₁₁ to C₃₀, six skeletal types being present: straight even, straight odd, iso, anteiso, other monomethyl branched and dimethyl branched. A large number of patterns of monoenes were observed, each pattern consisting of desaturation of a specific chain at Δ6 or Δ9 plus its extension or degradation products. The mole per cent of the total Δ6 and Δ9 patterns of wax ester fatty acid monoenes of vernix caseosa were 87% and 12%, respectively, and 98% and 1%, respectively, for adult human skin surface lipid. The sterol ester fatty acids of vernix caseosa were much different from those of adult human skin surface: vernix caseosa saturates were largely branched and of lengths greater than C₁₈, whereas the saturates of adult human surface lipid resembled the wax ester fatty acids. Of the vernix caseosa monoene patterns, the mole per cent was 30% Δ6 and 70% Δ9, whereas of the adult human skin surface sterol ester fatty acids 89% were Δ6 and 11% Δ9. Chain extension was particularly pronounced in the sterol ester fatty acid monoenes of vernix caseosa amounting to 7–8 C₂ units in some cases. The fatty acids of the sterol esters of both vernix caseosa and adult human skin surface appear to be derived from the sebaceous gland and from the keratinizing epidermis, but those of the wax esters are from the sebaceous glands only.