Editorial: Reliable Communication for Emerging Wireless Networks

Mobile Networks and Applications -     

Rigorous development of component-based systems using component metadata and patterns

In previous work we presented a CSP-based systematic approach that fosters the rigorous design of component-based development. Our approach is strictly defined in terms of composition rules, which are the only permitted way to compose components. These rules guarantee the preservation of properties (particularly deadlock freedom) by construction in component composition. Nevertheless, their application is allowed only under certain conditions whose verification via model checking turned out impracticable even for some simple designs, and particularly those involving cyclic topologies. In this paper, we address the performance of the analysis and present a significantly more efficient alternative to the verification of the rule side conditions, which are improved by carrying out partial verification on component metadata throughout component compositions and by using behavioural patterns. The use of metadata, together with behavioural patterns, demands new composition rules, which allow previous exponential time verifications to be carried out now in linear time. Two case studies (the classical dining philosophers, also used as a running example, and an industrial version of a leadership election algorithm) are presented to illustrate and validate the overall approach.     

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine

Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved during the last three decades. New high-throughput technologies have allowed a better understanding of the molecular basis of this disease and moved toward risk stratification, providing insights for targeted therapy studies. This knowledge, added to the pharmacogenetic profile of new and old agents in the analysis of efficacy and safety, could contribute to help clinical decisions move toward a precision medicine and a better clinical outcome for these patients. In this review, we describe the available literature concerning the genomic characterization and pharmacogenetics of plasma cell leukemia (PCL).     

The Nukiyama curve in water spray cooling: Its derivation from temperature–time histories and its dependence on the quantities that characterize drop impact

Heat transfer from hot aluminium walls to cold water sprays was investigated. The method used was the transient two-side symmetric cooling of a planar aluminium target, previously heated to temperatures of up to 750 K, by twin sprays issuing from full-cone swirl spray nozzles of various gauge. The target’s mid-plane temperature was recorded during the cooling transient by thin-foil K thermocouples and a high-frequency data acquisition system. In order to determine the wall temperature T_w, the wall heat flux and the heat transfer (Nukiyama) curve, two different approaches were used: the first was based on the solution of an inverse heat conduction problem, the second on a suitable parameterization of the Nukiyama curve and on the solution of a minimum problem. Relevant heat transfer quantities, such as the critical heat flux and the single-phase heat transfer coefficient, were obtained from each heat transfer curve. Their dependence on the main parameters characterizing the spray impact phenomenon (mass flow rate, drop velocity and drop diameter) was investigated on the basis of a preliminary hydrodynamic characterization study, and suitable correlations were proposed.     

Synthesis and characterization of differently substituted phenyl hepta isobutyl‐polyhedral oligomeric silsesquioxane/polystyrene nanocomposites

Variously substituted polyhedral oligomeric silsesquioxanes (POSSs)/polystyrene (PS) nanocomposites of general formula R₇R′(SiO_1.5)₈/PS (where R = isobutyl and R′ = 4‐methoxyphenyl, 4‐methylphenyl, 3,5‐dimethylphenyl, 4‐fluorophenyl, 2,4‐difluorophenyl, 4‐chlorophenyl) were prepared by in situ polymerization of styrene in the presence of 5% w/w of POSS. The actual filler concentration in the obtained nanocomposites was checked by ¹H NMR spectroscopy. Scanning electron microscopy and FTIR spectroscopy evidenced the presence of filler‐polymer interactions. Inherent viscosity (η_inh) determinations indicated that the average molar mass of polymer in halogenated derivatives was lower than neat PS, and were in agreement with calorimetric glass transition temperature (T_g) measurements. Finally, a comparative study concerning the thermal stability of synthesized nanocomposites was carried out in both inert (flowing nitrogen) and oxidative (static air) atmospheres into a thermobalance, in the scanning mode, at 10°C min⁻¹, and the temperatures at 5% mass loss (T_5%), of various compounds were determined. The results were discussed and interpreted. POLYM. COMPOS., 35:151–157, 2014. © 2013 Society of Plastics Engineers     

Synthesis and thermal characterization of new dumbbell shaped POSS/PS nanocomposites: Influence of the symmetrical structure of the nanoparticles on the dispersion/aggregation in the polymer matrix

A series of three novel dumbbell shaped polyhedral oligomeric silsesquioxanes (POSS)/ polystyrene (PS) nanocomposites, at different POSS contents (3%, 5% and 10% w/w), was synthesized and characterized in order to investigate the effects of this new bridged structure on the filler‐polymer interaction and then on the thermal behavior of the obtained polymer nanostructured materials (PNMs). Nanocomposites were synthesized by in situ polymerization of styrene and the actual POSS concentration in the obtained PNMs was checked by ¹H NMR spectroscopy. Scanning electron microscopy (SEM) and FTIR spectroscopy evidenced, at the same time, the presence of filler‐polymer interactions and auto‐aggregation phenomena. Degradations were carried out into a thermobalance, in the scanning mode, at various heating rates in both inert and oxidative atmospheres. The characteristic parameters of thermal stability, namely temperature at 5% mass loss and the apparent activation energy of degradation, for the various nanocomposites were determined and an increase in the initial decomposition temperatures of PNMs with increasing the POSS contents was observed. The results are discussed and interpreted. POLYM. COMPOS., 36:1394–1400, 2015. © 2014 Society of Plastics Engineers     

Sintering,high temperature strength and oxidation resistance of liquid-phase-pressureless-sintered SiC–AlN ceramics with addition of rare-earth oxides

SiC–AlN composites can be pressureless sintered with the addition of rare-earth oxides (RE = Y, Yb, Er, Lu, Ho, Sm, Ce) and without protective powder bed. Sintered bodies showed high density (≥97% T.D.) and were mainly composed by 2H SiC–AlN solid solution with additive containing grain boundary phases. The high temperature strength and oxidation resistance of the composites were also investigated and correlated with the cationic radii of the oxide additives. The flexural strength at 1500 °C increased from 269 MPa to 587 MPa as direct consequence of the rare-earth cationic radius decrease. The specific weight gain during oxidation at 1500 °C for 200 h showed the same behaviour, decreasing from 12.60 mg/cm² to 3.13 mg/cm².     

Evaluation of the assumptions used to derive an ideal normal cervical spine model

OBJECTIVES: To evaluate the accuracy of anatomical assumptions made to derive a geometrical, ideal, normal model of the upright, static, sagittal cervical spine, to make comparisons with other spinal models and to discuss the implications of a normal cervical model. BACKGROUND: Anatomical assumptions were made based on observations to assist in the development of a computerized geometrical model of the ideal upright, static, sagittal cervical spine. These assumptions address the magnitudes of the contribution made by the vertebral bodies and intervertebral discs to the overall magnitude and geometric shape of the cervical lordosis. STUDY DESIGN: (a) Data were collected from 400 lordotic lateral cervical radiographs and compared with the predictions of a geometric normal cervical lordotic model. Angels of intersecting tangent lines, drawn at posterior vertebral body margins, were measured at each disc space and between C2 and C7. Height-to-length ratios and an anterior weight-bearing distance were measured. (b) Literature reviews were obtained through Medline and Chirolars. RESULTS: (a) Modeling: the 400 sample subjects varied from the geometric model by approximately 5%. Subgroup averages, from partitioning the C2-C7 angle into 5 degrees intervals, were less than 8% in error to model predictions. (b) Literature review: lordosis is the normal configuration for the cervical spine and many chiropractic empirical models are similar. CONCLUSIONS: The anatomical assumptions used to derive our normal geometric model of the cervical lordosis seem to be supported by the average values and literature reviewed. Two typical geometric configurations of the cervical spine were identified as a normal circular lordotic arc of 34 degrees and an ideal normal of 42 degrees. Literature reviewed establishes cervical lordosis as a desirable clinical outcome of care.     

Memory effects in annealed hybrid gold nanoparticles/block copolymer bilayers

We report on the use of the self-organization process of sputtered gold nanoparticles on a self-assembled block copolymer film deposited by horizontal precipitation Langmuir-Blodgett (HP-LB) method. The morphology and the phase-separation of a film of poly-n-butylacrylate-block-polyacrylic acid (PnBuA-b-PAA) were studied at the nanometric scale by using atomic force microscopy (AFM) and Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS). The templating capability of the PnBuA-b-PAA phase-separated film was studied by sputtering gold nanoparticles (NPs), forming a film of nanometric thickness. The effect of the polymer chain mobility onto the organization of gold nanoparticle layer was assessed by heating the obtained hybrid PnBuA-b-PAA/Au NPs bilayer at T >T _g. The nanoparticles' distribution onto the different copolymer domains was found strongly affected by the annealing treatment, showing a peculiar memory effect, which modifies the AFM phase response of the Au NPs layer onto the polar domains, without affecting their surfacial composition. The effect is discussed in terms of the peculiar morphological features induced by enhanced mobility of polymer chains on the Au NPs layer.