Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound

A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported.     

Color encoding for polychromatic single-channel optical pattern recognition

The common multichannel system for recognizing colored images is replaced by a color-encoded single-channel system. Amethod inspired by the Munsell color system is used for encoding the different colors as phase and amplitude functions. It is shown that for many practical cases the phase information part of the color code is sufficient for obtaining good results. An implementation based on a liquid-crystal television panel that works in a phase-modulation mode is suggested. Computer simulations that demonstrate the capabilities of the suggested method are given as well as a comparison with previously published multichannel performance.     

High resolution CMOS current comparators: design and applications to current-mode function generation

This paper uses fundamental models to derive design conditions for maximum speed and resolution in CMOS transimpedance comparators. We distinguish two basic comparator architectures depending on whether the input sensing node is resistive or capacitive, and show that each type yields advantages for different ranges of input current. Then, we introduce a class of current comparator structures which use nonlinear sensing and/or feedback to combine the advantages of capacitive-input and resistive-input architectures. Two members of this class are presented demonstrating resolution levels (measured on silicon prototypes) in the range of pAs. They exhibit complementary functional features: one, the current steering comparator, displays better transient response in the very comparison function, while operation of the other, the current switch comparator, is easily extended to support systematic generation of nonlinear transfer functions in current domain. The paper explores also this latter extension, and presents current-mode circuit blocks for systematic generation of nonlinear functions based on piecewise-linear (PWL) approximation. Proposals made in the paper are demonstrated via CMOS prototypes in two single-poly CMOS n-well technologies: 2m and 1.6m. These prototypes show measured input current comparison range of 140 dB, resolution and offset below 10 pA, and operation speed two orders of magnitude better than that of conventional resistive-input circuits. Also, measurements from the PWL prototypes show excellent rectification properties (down to a few pAs) and small linearity errors (down to 0.13%).     

Equivalent-optical-waveguide model for the analysis of optical waveguides by means of an asymptotic effective-index method

We present a theoretical method that makes it possible to analyze three-dimensional (3-D) integrated optical waveguides with arbitrary refractive-index profiles. With this method it is easy to obtain effective indexes, propagation constants, and coupling-switching properties of planar and channel optical waveguides. This theoretical approach involves one's modeling the original optical waveguide by means of an equivalent optical waveguide whose effective index is evaluated by the application of a technique that we call the asymptotic effective-index method. The numerical values show good convergence and accuracy for effective indexes, propagation constants, and coupling-switching characteristics. Theoretical and experimental results are given.     

Pollution imagery by optical interferometry: application to SO(2) gas

The interferometric correlation method can provide a simple and inexpensive solution for pollution imagery, especially in the case of a spatially localized gaseous cloud. We describe herein a general method for designing an interferometric correlator for the analysis of any pollutant gas that has regularly distributed absorption spectral lines. We also present a setup using a birefringent interferometer in front of a simplified camera formed by a plano-convex lens and a linear CCD sensor; this demonstrates the monitoring of SO(2) gas. Results from the laboratory simulation show the feasibility of this method. Outdoor measurements permit determination of the required conditions for on-site real-time measurement.     

Comparison of some components of pigs kept in natural (free-range) and large-scale conditions

A new pig genotype of Hungarian Large White (75%) × Mangalica (pig with curly bristles, 25%) was used in the experiments. The experimental group was kept in a farming system under strictly natural circumstances until a body weight of 120 kg was attained. Neither antibiotics nor yield-increasing hormones were given to this group. The control group was kept in the usual large-scale farming conditions until body weight of 120 kg was attained. In most cases, protein, zinc, and copper levels and, in some cases, iron levels were significantly higher in some major cuts (neck-end (Boston-butt), loin, ham) of the 'free-range' pigs (n = 12) in comparison with the control animals kept in large-scale farming conditions. There was, on average, 15% less cholesterol in the muscles and 30% less cholesterol in the liver and less linoleic acid in all tissues of 'free-range' pigs than in the control group. There was less fat, but the amount of thiamin and riboflavin in the liver of the naturally kept pigs was twice that in the controls. In respect of TBA-reactive compounds, there were no significant differences between the two groups, but superoxide dismutase (SOD) showed significantly higher activities in all cuts from pigs kept in a large-scale farming system. This may be the effect of a higher level of linoleic acid in the fat.     

Microbial growth and biochemical changes on naturally contaminated chilled-beef subcutaneous adipose tissue stored aerobically

Naturally contaminated beef-brisket fat showed a psychrotroph count of 4 × 10(9) CFU/cm(2) after 14 days of aerobic refrigerated storage (5°C ± 1°C). Pseudomonas was the predominating genus. Other micro-organisms, such as Enterobacteriaceae and Brochothrix thermosphacta, grew up to 2·5 × 10(8) cfu/cm(2) and 1·6 × 10(8) cfu/cm(2), respectively. Concentrations of different substrates that could support microbial growth were measured. Glucose concentration dropped to approximately one-third of the initial level during the first week of storage. Lactic acid also declined. Free fatty acids increased significantly (P < 0·05) during refrigeration. However, other lipid-deterioration indices, such as the thiobarbituric acid number and the peroxide value, remained unchanged. Beef subcutaneous fat had a high initial microbial load and a capacity to support extensive bacterial growth. It may therefore constitute an important source of contamination for meat and manufactured meat products.     

State of the Art of Molecular Visualization in Immersive Virtual Environments

Visualization plays a crucial role in molecular and structural biology. It has been successfully applied to a variety of tasks, including structural analysis and interactive drug design. While some of the challenges in this area can be overcome with more advanced visualization and interaction techniques, others are challenging primarily due to the limitations of the hardware devices used to interact with the visualized content. Consequently, visualization researchers are increasingly trying to take advantage of new technologies to facilitate the work of domain scientists. Some typical problems associated with classic 2D interfaces, such as regular desktop computers, are a lack of natural spatial understanding and interaction, and a limited field of view. These problems could be solved by immersive virtual environments and corresponding hardware, such as virtual reality head-mounted displays. Thus, researchers are investigating the potential of immersive virtual environments in the field of molecular visualization. There is already a body of work ranging from educational approaches to protein visualization to applications for collaborative drug design. This review focuses on molecular visualization in immersive virtual environments as a whole, aiming to cover this area comprehensively. We divide the existing papers into different groups based on their application areas, and types of tasks performed. Furthermore, we also include a list of available software tools. We conclude the report with a discussion of potential future research on molecular visualization in immersive environments.     

Recent Advances on High-Speed and Holographic Two-Photon Direct Laser Writing

Two-Photon Lithography, thanks to its very high sub-diffraction resolution, has become the lithographic technique par excellence in applications requiring small feature sizes and complex 3D pattering. Despite this, the fabrication times required for extended structures remain much longer than those of other competing techniques (UV mask lithography, nanoimprinting, etc.). Its low throughput prevents its wide adoption in industrial applications. To increase it, over the years different solutions have been proposed, although their usage is difficult to generalize and may be limited depending on the specific application. A promising strategy to further increase the throughput of Two-Photon Lithography, opening a concrete window for its adoption in industry, lies in its combination with holography approaches: in this way it is possible to generate dozens of foci from a single laser beam, thus parallelizing the fabrication of periodic structures, or to engineer the intensity distribution on the writing plane in a complex way, obtaining 3D microstructures with a single exposure. Here, the fundamental concepts behind high-speed Two-Photon Lithography and its combination with holography are discussed, and the literary production of recent years that exploits such techniques is reviewed, and contextualized according to the topic covered.