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51.
A simple integration of molecular and colloidal self-assembly approaches with photopatterning is shown to produce multifunctional patterns of amphiphilic colloidal crystals. These crystals display binary spatial patterns of wettability by water and a single photonic stop-band in air. Upon exposure to water, the uniform stop-band is replaced by a pattern of coexisting stop-bands that reflect the underlying pattern of surface wetting. These hydration-dependent photonic patterns within single colloidal crystals form because of near-complete water rejection from the three-dimensionally disposed nanoscale interstices in hydrophobic regions and its exclusive permeation within the hydrophilic regions. This water permeation pattern is further structured by the three-dimensional (3D) distribution and contiguity of the nanoscale interstices between individual colloids, allowing 3D patterned organization of functional units in secondary self-assembly processes, as illustrated using quantum dots, metal nanoparticles, and fluorescent probes. 相似文献
52.
Evaluation of (4‐Arylpiperidin‐1‐yl)cyclopentanecarboxamides As High‐Affinity and Long‐Residence‐Time Antagonists for the CCR2 Receptor
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Dr. Maris Vilums Dr. Annelien J. M. Zweemer Arian Dilanchian Jacobus P. D. van Veldhoven Henk de Vries Dr. Johannes Brussee Dr. John Saunders Dr. Dean Stamos Dr. Laura H. Heitman Prof. Adriaan P. IJzerman 《ChemMedChem》2015,10(7):1249-1258
Animal models suggest that the chemokine ligand 2/CC‐chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy. We previously described a new approach for the design of CCR2 antagonists by the use of structure–kinetics relationships (SKRs). Herein we report new findings on the structure–affinity relationships (SARs) and SKRs of the reference compound MK‐0483, its diastereomers, and its structural analogues as CCR2 antagonists. The SARs of the 4‐arylpiperidine group suggest that lipophilic hydrogen‐bond‐accepting substituents at the 3‐position are favorable. However, the SKRs suggest that a lipophilic group with a certain size is desired [e.g., 3‐Br: Ki=2.8 nM , residence time (tres)=243 min; 3‐iPr: Ki=3.6 nM , tres=266 min]. Alternatively, additional substituents and further optimization of the molecule, while keeping a carboxylic acid at the 3‐position, can also prolong tres; this was most prominently observed in MK‐0483 (Ki=1.2 nM , tres=724 min) and a close analogue (Ki=7.8 nM ) with a short residence time. 相似文献
53.
Assessing footwear slip-resistance is critical to preventing slip and fall accidents. The STM 603 (SATRA Technology) is commonly used to assess footwear friction but its ability to predict human slips while walking is unclear. This study assessed this apparatus’ ability to predict slips across footwear designs and to determine if modifying the test parameters alters predictions. The available coefficient of friction (ACOF) was measured with the device for nine different footwear designs using 12 testing conditions with varying vertical force, speed and shoe angle. The occurrence of slipping and the required coefficient of friction was quantified from human gait data including 124 exposures to liquid contaminants. ACOF values varied across the test conditions leading to different slip prediction models. Generally, a steeper shoe angle (13°) and higher vertical forces (400 or 500?N) modestly improved predictions of slipping. This study can potentially guide improvements in predictive test conditions for this device.
Practitioner Summary: Frictional measures by the STM603 (SATRA Technology) were able to predict human slips under liquid contaminant conditions. Test parameters did have an influence on the measurements. An increased shoe-floor testing angle resulted in better slip predictions than test methods specified in the ASTM F2913 standard. 相似文献
54.
Ghorbanpour Arani Ali BabaAkbar-Zarei Hassan Pourmousa Pouya Eskandari Masume 《Microsystem Technologies》2018,24(7):3045-3060
Microsystem Technologies - In this paper, free vibration analysis of sandwich composite micro-beam (SCMB) subjected to multi physical fields is investigated using the sinusoidal shear deformation... 相似文献
55.
56.
A numerical model on nonlinear vibration of double-walled carbon nanotubes (DWCNTs) subjected to a moving nanoparticle and multi physical fields is proposed. DWCNTs are considered with the kinematic assumption of Euler–Bernoulli beam theory. The surrounding elastic substrate is simulated as Pasternak foundation, which is assumed to be temperature-dependent. Hamilton's principle, incremental harmonic balanced method, Galerkin, and time integration method with direct iteration are employed to establish the equations of motion of zigzag DWCNTs. The study reveals that for the weak van der Waals forces, DWCNTs have the positive and the negative deflections as if it vibrates under a moving nanoparticle. 相似文献
57.
A. Loghman A. Askari Kashan M. Younesi Bidgoli A. R. Shajari A. Ghorbanpour Arani 《Journal of Mechanical Science and Technology》2013,27(4):1041-1051
The effects of particle content, particle size, operating temperature and magnetic field on steady-state creep behavior of thick-walled rotating cylinders made of Al-SiC composites have been investigated. Loading is composed of a uniform magnetic field in axial direction, steady-state heat conduction in radial direction and an inertia body force due to rotation. The composite creep constitutive equation has been described by Norton’s law in which the creep parameters are functions of particle size, temperature and particle content. The composite properties are radial dependent based on volume fraction of SiC reinforcement. It has been found that the minimum effective creep strain rate belongs to a composite identified by 25% SiC at the inner and 5% at the outer surfaces. Therefore this composite has been selected for the design of the cylinder. It has been concluded that increasing particle size and operating temperature significantly increases the effective creep strain rates. It has also been illustrated that magnetic field decreases the stresses and the effective creep strain rates. 相似文献
58.
OBJECTIVE: The life events model was extended to the political arena to enable the comparison of children's adjustment reactions to political stress. The cross-cultural impact of adverse political events on psychological adjustment was examined for two closely matched research samples, Arab and Jewish children and Palestinian and Israeli children. METHOD: All children completed the Political Life Events scale and the Brief Symptom Inventory in their home languages. RESULTS: The hypothesis of a linear relation between adverse events and psychological distress was not confirmed in both studies. In study 1, a direct relation emerged for both Jewish and Arab Israeli children. However, in study 2, when separated by nationality, results revealed opposite trends for each nation. For Israelis there was a linear relation, but for Palestinians there was a consistent inverse relation between increased severity of political life events exposure and distress, both for the global index and for specific symptomatology. CONCLUSION: It is proposed that these cross-cultural results stem from differential mediating coping mechanisms, specifically passive versus active strategies, which intervene between the stressor-adjustment link. The need to address short- and long-term consequences of political stress on children's mental health is discussed. 相似文献
59.
Edge distance effects on residual stress distribution around a cold expanded hole in Al 2024 alloy 总被引:2,自引:0,他引:2
Cold expansion process is a well-known technique for improving the fatigue life of aerospace structures by introducing a compressive residual stress around the fastener holes. However, there are concerns about the residual stress distribution around those holes which are located near the free edges of structure. The purpose of this study is to investigate the influence of edge distance ratio (e/D) on the residual stress distribution around a cold expanded hole in Al 2024 alloy. A two-dimensional finite element simulation was carried out with various degrees of cold expansion and various values of e/D. It was found that for edge distance ratios less than e/D = 3, there are considerable effects on the residual stress profile. Also, the dependency of residual stress distribution on the degree of expansion was reduced significantly for small e/Ds. The results revealed that the bulging of the plate free edge increases with reduction of e/D but in worse cases the maximum bulging at the plate free edge was lower than 3% of the hole radius. The weight function method was then used for determining stress intensity factors for a crack emanating from a cold expanded hole. 相似文献
60.
This research investigates the free vibration and buckling of a two-layered cylindrical shell made of inner functionally graded (FG) and outer isotropic elastic layer, subjected to combined static and periodic axial forces. Material properties of functionally graded cylindrical shell are considered as temperature dependent and graded in the thickness direction according to a power-law distribution in terms of the volume fractions of the constituents. Theoretical formulations are presented based on two different methods of first-order shear deformation theory (FSDT) considering the transverse shear strains and the rotary inertias and the classical shell theory (CST). The results obtained show that the transverse shear and rotary inertias have considerable effect on the fundamental frequency of the FG cylindrical shell. The results for nondimensional natural frequency are in a close agreement with those in literature. It is inferred from the results that the geometry parameters and material composition of the shell have significant effect on the critical axial force, so that the minimum critical load is obtained for fully metal shell. Good agreement between theoretical and finite element results validates the approach. It is concluded that the presence of an additional elastic layer significantly increases the nondimensional natural frequency, the buckling resistance and hence the elastic stability in axial compression with respect to a FG hollow cylinder. 相似文献