An innovative device for instant measurement of Surface Electro-Myography for clinical use

Surface Electro-Myography (SEMG) signal plays key roles for clinical measurement. The strength of this signal at different instant of time and at different places of our body shows the respective muscle strength and identify if any types of muscles fatigue occurs or not. This is useful for sports personnel’s and especially for amputees and different orthopedic patients. The surgeon should have a vivid knowledge about the muscle strength of any part of human body. So a portable hand carrying device is necessary. In this paper we want to illustrate a proposed system which can indicate the strength as well as display the RMS value of the collected Electro-Myography signal on a proposed trainer board consists of a LED bar which indicates the respective strength of the signal in volts. The following system has also a provision to display the strength pattern in a PC in Lab View environment. This shows a detailed analysis of the EMG signal in respect to its waveform, equivalent DC value etc.     

Optimum lateral extent of soil domain for dynamic SSI analysis of RC framed buildings on pile foundations

This article describes a novel approach for deciding optimal horizontal extent of soil domain to be used for finite element based numerical dynamic soil structure interaction (SSI) studies. SSI model for a 12 storied building frame, supported on pile foundation-soil system, is developed in the finite element based software framework, OpenSEES. Three different structure-foundation configurations are analyzed under different ground motion characteristics. Lateral extent of soil domain, along with the soil properties, were varied exhaustively for a particular structural configuration. Based on the reduction in the variation of acceleration response at different locations in the SSI system (quantified by normalized root mean square error, NRMSE), the optimum lateral extent of the soil domain is prescribed for various structural widths, soil types and peak ground acceleration levels of ground motion. Compared to the past studies, error estimation analysis shows that the relationships prescribed in the present study are credible and more inclusive of the various factors that influence SSI. These relationships can be readily applied for deciding upon the lateral extent of the soil domain for conducting precise SSI analysis with reduced computational time.     

Full-scale validation of vortex suppression techniques for mitigation of roof uplift

Widespread damage to roofs in hurricanes and other high wind events has highlighted the need for improving the wind performance of roofs, including both new construction and retrofit on existing buildings. Effective and economical methods to mitigate wind effects on roof components are sought to reduce accumulated losses from frequently recurring low- and moderate-intensity events. An experimental study was carried out in the 6-fan Wall of Wind (WoW) testing apparatus to assess the effectiveness of aerodynamic edge devices at full scale in reducing wind effects over the roof corner and edge regions. Two sets of tests, roof gravel scour testing and pressure testing, were carried out to visualize the development of edge vortices and compare roof uplift pressures with and without aerodynamic edge shapes, thus allowing the estimation of the effects of such shapes in alleviating wind damage of roofing material as well as high uplift pressures on roofs. Probabilistic estimates of peak pressures indicated that the use of such mitigation devices resulted in significant reductions in uplift within the instrumented area, which according to the US wind load specifications (ASCE 7-05) represents a corner section of the roof that will experience the highest suction. The largest reduction was achieved with the Flat Roof AeroEdge Guard (FRAG1). This research demonstrates the potential for substantial reduction of roof uplift pressures through the development and application of mitigation techniques to lessen or prevent hurricane-induced damage to new and existing roofs.     

Physicochemical Characterization of Interaction of Ibuprofen by Solid-State Milling with Aluminum Hydroxide

This present study is a preliminary exploration of the affinity between a carboxylic model drug ibuprofen and aluminum hydroxide. Ibuprofen was comilled with aluminum hydroxide in different weight ratios in the solid state and was characterized by scanning electron microscopy (SEM), X-ray powder diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution studies. XRD and SEM studies indicated complete interaction of ibuprofen with aluminum hydroxide and complete amorphization of aluminum hydroxide–ibuprofen complexed salt as well, on comilling with aluminum hydroxide at 1:2 ratio. FTIR data showed the disappearance of acid carbonyl peak with the appearance and the corresponding increase in absorbance of new signal at 1,682 cm^?1 in the 1:1 and 1:2 ibuprofen–aluminum hydroxide-comilled powder. The accompanied increase in the absorbance of carboxylate peak in the ibuprofen–aluminum hydroxide physical mixture, and 1:0.1, 1:0.5, 1:1, and 1:2 (IBA_pm, and IB₁A_0.1, IB₁A_0.5, IB₁A₁, and IB₁A₂, respectively) comilled powder indicated an acid–base reaction between ibuprofen and aluminum hydroxide. On storage at 40°C and 75% relative humidity (RH) for 10 weeks, XRD study showed the absence of reversion to the crystalline state and FTIR data revealed continued increase of new signal at 1,682 cm^?1 relative to carboxylic acid peak and no reappearance of carboxylic acid peak. In vitro dissolution studies revealed that the percent release of ibuprofen from the aluminum hydroxide-comilled powder is in the following order: IB₁A₂ < IB₁A₁ < ibuprofen crystal < ibuprofen milled alone < IB₁A_0.1 < IB₁A_0.5. Aluminum metal cation might have interacted to form a complex through the carboxyl and carbonyl groups of ibuprofen. Improved dissolution of drug associated with IB₁A_0.1 and IB₁A_0.5 is because of the absence of a new signal at 1,682 cm^?1 and improved amorphization of the drug to some extent. Dissolution of drug affected in IB₁A₂ and IB₁A₁ may be because of the insoluble stable complex formation.     

Designing Stimuli-Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

Tailoring personalized cancer nanomedicines demands detailed understanding of the tumor microenvironment. In recent years, smart upconversion nanoparticles with the ability to exploit the unique characteristics of the tumor microenvironment for precise targeting have been designed. To activate upconversion nanoparticles, various bio-physicochemical characteristics of the tumor microenvironment, namely, acidic pH, redox reactants, and hypoxia, are exploited. Stimuli-responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn²⁺ in tumors. An overview of the design of stimulus-responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. Detailed understanding of the tumor microenvironment and the personalized design of upconversion nanoparticles will result in more effective clinical translation.     

Metal Organic Framework Derived Materials: Progress and Prospects for the Energy Conversion and Storage

Exploring new materials with high efficiency and durability is the major requirement in the field of sustainable energy conversion and storage systems. Numerous techniques have been developed in last three decades to enhance the efficiency of the catalyst systems, control over the composition, structure, surface area, pore size, and moreover morphology of the particles. In this respect, metal organic framework (MOF) derived catalysts are emerged as the finest materials with tunable properties and activities for the energy conversion and storage. Recently, several nano‐ or microstructures of metal oxides, chalcogenides, phosphides, nitrides, carbides, alloys, carbon materials, or their hybrids are explored for the electrochemical energy conversion like oxygen evolution, hydrogen evolution, oxygen reduction, or battery materials. Interest on the efficient energy storage system is also growing looking at the practical applications. Though, several reviews are available on the synthesis and application of MOF and MOF derived materials, their applications for the electrochemical energy conversion and storage is totally a new field of research and developed recently. This review focuses on the systematic design of the materials from MOF and control over their inherent properties to enhance the electrochemical performances.     

Stochastic multiscale fracture analysis of three-dimensional functionally graded composites

A new moment-modified polynomial dimensional decomposition (PDD) method is presented for stochastic multiscale fracture analysis of three-dimensional, particle-matrix, functionally graded materials (FGMs) subject to arbitrary boundary conditions. The method involves Fourier-polynomial expansions of component functions by orthonormal polynomial bases, an additive control variate in conjunction with Monte Carlo simulation for calculating the expansion coefficients, and a moment-modified random output to account for the effects of particle locations and geometry. A numerical verification conducted on a two-dimensional FGM reveals that the new method, notably the univariate PDD method, produces the same crude Monte Carlo results with a five-fold reduction in the computational effort. The numerical results from a three-dimensional, edge-cracked, FGM specimen under a mixed-mode deformation demonstrate that the statistical moments or probability distributions of crack-driving forces and the conditional probability of fracture initiation can be efficiently generated by the univariate PDD method. There exist significant variations in the probabilistic characteristics of the stress-intensity factors and fracture-initiation probability along the crack front. Furthermore, the results are insensitive to the subdomain size from concurrent multiscale analysis, which, if selected judiciously, leads to computationally efficient estimates of the probabilistic solutions.     

Peptide-assisted synthesis of gold nanoparticles and their self-assembly

A novel gold nanoparticle-tripeptide (GNP-tripeptide) conjugate was prepared by peptide in-situ redox technique at ambient temperatureusing a newly designed tripeptide. This new tripeptide was nso designed that it has a C-terminus tyrosine residue, which reduced Au+3 to Au, and the terminally located free amino group was bound to the gold nanoparticle (GNP) surface resulting in highly stable Au colloids. The average diameter of the tripeptide-stabilized GNP is 8.7 +/- 2.3 nm. Tripeptide bound gold nanoparticles formed three-dimensional assemblies in the presence of an excess of similar or disimilar tripeptides. The aggregation of GNPs results in a red shift in the surface plasmon resonance from lambda max = 527 to 556 nm. The effect of the solvent, concentration, and nature of the tripeptides on the assembly process were investigated by TEM and UV-visible spectroscopy.     

The Structure And Properties of a Thermo‐mechanically Processed Low Carbon High Strength Steel

Research efforts were given towards development of low carbon high strength steels since recent past. The present study deals with the development of a low carbon high strength steel alloyed with Mn, Ni, Mo, Cu and microalloyed with Ti and Nb. The steel was subjected to three stage controlled rolling operation followed by accelerated cooling. The structure and properties of the steel at various processing conditions were evaluated. Microstructural observation reveals predominantly lath martensite along with twinned martensite structure at all processing conditions. High strength values at higher finish rolling temperatures have been obtained due to fine martensitic structure along with tiny precipitates of microalloying carbide and carbonitride. The strength value increases marginally at lower finishing temperature due to comparatively finer lath size of martensite and increased precipitation density of carbides, carbonitrides along with Cu particles. The variation in impact toughness properties at different finish rolling temperatures is found to be negligible at ambient and subambient temperatures. The formation of stable and large TiN/TiCN particles during casting have impaired the impact toughness values at ambient and at ‐40°C temperatures.     

Scour Downstream of an Apron Due to Submerged Horizontal Jets

The results of an experimental investigation on scour of noncohesive sediment beds (uniform and nonuniform sediments) downstream of an apron due to a submerged horizontal jet issuing from a sluice opening are presented. Attempts are made to explain the similarity existing in the scour process and profiles (including dune in the downstream of the scour hole). The scour profiles at different times follow a particular geometrical similarity and can be expressed by the combination of two polynomials. Using experimental scour depth at different times, the time variation of scour depth is scaled by an exponential law, where time scale increases linearly with densimetric Froude number. The equilibrium scour depth, related to the sediment size relative to the sluice opening, decreases with increase in sediment size and sluice opening. On the other hand, the equilibrium scour depth increases with increase in densimetric Froude number. The variation of equilibrium scour depth with tailwater depth indicates a critical tailwater depth corresponding to a minimum equilibrium scour depth. The effect of sediment gradation on scour depth is pronounced for nonuniform sediments, which reduce scour depth significantly due to formation of an armor layer, and therefore prompted study of the reduction of scour depth by a launching apron placed downstream of the rigid apron. The results show that the average reduction of scour depth by placing a launching apron was 39%, having a maximum of 57.3% and a minimum of 16.2%. The characteristic parameters affecting maximum equilibrium scour depth are identified based on the physical reasoning and dimensional analysis. Equation of maximum equilibrium scour depth obtained empirically agrees well with the experimental data.