Photo-vulcanization using thiol-ene chemistry: Film formation,morphology and network characteristics of UV crosslinked rubber latices

The photo-vulcanization with versatile thiol-ene chemistry represents an innovative approach to crosslink diene-rubber materials both in latex and in solid film state. In this work, the structure of elastomer-based thiol-ene networks and the morphology after film formation are studied in detail using electron microscopic techniques, atomic force microscopy and multiple-quantum solid-state NMR spectroscopy. Additionally, film formation properties and corresponding macroscopic properties of photo-vulcanized natural rubber (NR) latex and its synthetic counterpart, isoprene rubber (IR) latex, are determined in dependence on the curing procedure (pre- and post-vulcanization). The results reveal that thiol-ene cured elastomers comprise homogenously distributed crosslinks with a low amount of short chain defects. Whilst photochemically pre-cured NR latex particles provide coherent films, the film formation and mechanical properties of IR are strongly governed by the crosslink density of the latex particles. In film state, photo-vulcanization promotes narrow crosslink distributions and excellent tensile properties of both NR and IR.     

优化车门ECU功耗的新概念

<正>在现代汽车中,电子控制单元(ECU)的数量不断增长。现代电子零部件增加了许多功能可为驾驶员提供更多的信息和更舒适的环境,     

The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model

Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality. Therefore, groundbreaking research and innovations are necessary. Research in space under microgravity (µg) conditions is a novel approach with the potential to fight cancer and develop future cancer therapies. Space travel is accompanied by adverse effects on our health, and there is a need to counteract these health problems. On the cellular level, studies have shown that real (r-) and simulated (s-) µg impact survival, apoptosis, proliferation, migration, and adhesion as well as the cytoskeleton, the extracellular matrix, focal adhesion, and growth factors in cancer cells. Moreover, the µg-environment induces in vitro 3D tumor models (multicellular spheroids and organoids) with a high potential for preclinical drug targeting, cancer drug development, and studying the processes of cancer progression and metastasis on a molecular level. This review focuses on the effects of r- and s-µg on different types of cells deriving from thyroid, breast, lung, skin, and prostate cancer, as well as tumors of the gastrointestinal tract. In addition, we summarize the current knowledge of the impact of µg on cancerous stem cells. The information demonstrates that µg has become an important new technology for increasing current knowledge of cancer biology.     

Transparente leitfähige Nitride

Transparent conductive nitrides – New perspectives in device design More than 20 years after the pioneer of the GaN LED Nobel laureate Shuji Nakamura published that germanium is an inferior dopand for GaN when compared to silicon we showed that the opposite is true in regard of achievable n-type doping concentration. With Ge-doped GaN now device performance can be improved and new device structures realized. As transparent highly conductive nitride (TCN) new application fields emerge for GaN, in particular the replacement of ITO. Besides many potential applications Ge-doped GaN layers also show interesting physics as a new quasiparticle, the Collexon.     

应用为王价值优先技嘉全新主板应用技术详解

主板是所有主机内部硬件的载体,所以说每个硬件跟它都有非常密切的联系。如果主板只能提供芯片组原有的基本功能,那么一线大厂和普通的通路厂商就没有任何区别了。主板要给用户带来的是一套整体的解决方案,它不仅要利用主板自身的功能和特点,更应该高效、合理地结合插在主板上的各种硬件,更方便、更高效、更人性化地为它的用户服务。     

超频在云端技嘉Cloud O.C云超频技术体验

这个世界上有两种人,要超频的和不超频的。要超频的人分为两种,一种是为了挑战世界纪录超频的人,改造主板、液氮散热……1MH也会兴奋得睡不着觉。但这个世界上更多的超频人士仅仅是需要通过超频来获得性能提升,超频方法越轻松越好,越简单越好。云超频？没听说过？那真是不够潮了!这是一种超便捷、超简单的超频方式,而且是在使用手机或者是iPad来玩超频。     

AI-Based Supervision for a Stirred Extraction Column Assisted with Population Balance-Based Simulation

Solvent extraction as environmental benign separation technique can be modeled in physical detail by population balance of the droplet size distribution. However, much information on the droplet generation and coalescence is necessary for representative results. In this contribution, we present a comparison of AI-evaluated experimental and simulated data on the behavior of a stirred solvent extraction column with an inner diameter of 32 mm. Lab experiments were performed using the standard test system with n-butyl acetate, acetone, and deionized water. A digital camera is placed in front of the middle section as well as the head of the column. Droplet size evaluation is performed using a retrained neural net (Mask R-CNN). The stirred DN32 extraction column is modeled and simulated using a 1D CFD population balance software. The simulation allows for behavior analysis, trends comparison, and validation of the hydrodynamics and mass transfer performances.     

Innovative Diagnostic Peptide-Based Technologies for Cancer Diagnosis: Focus on EGFR-Targeting Peptides

Active targeting using biological ligands has emerged as a novel strategy for the targeted delivery of diagnostic agents to tumor cells. Conjugating functional targeting moieties with diagnostic probes can increase their accumulation in tumor cells and tissues, enhancing signal detection and, thus, the sensitivity of diagnosis. Due to their small size, ease of chemical synthesis and site-specific modification, high tissue penetration, low immunogenicity, rapid blood clearance, low cost, and biosafety, peptides offer several advantages over antibodies and proteins in diagnostic applications. Epidermal growth factor receptor (EGFR) is one of the most promising cancer biomarkers for actively targeting diagnostic and therapeutic agents to tumor cells due to its active involvement and overexpression in various cancers. Several peptides for EGFR-targeting have been identified in the last decades, which have been obtained by multiple means including derivation from natural proteins, phage display screening, positional scanning synthetic combinatorial library, and in silico screening. Many studies have used these peptides as a targeting moiety for diagnosing different cancers in vitro, in vivo, and in clinical trials. This review summarizes the progress of EGFR-targeting peptide-based assays in the molecular diagnosis of cancer.     

Enzymatic hydrolysis of polyester based coatings

The potential of two hydrolytic enzymes, namely a lipase from Thermomyces lanuginosus (TlL) and a cutinase from Humicola insolens (HiC) for hydrolysis of the phthalic acid backbone based polyester coatings was assessed. Two phthalic acid/trimethylolpropane based model substrates resembling the structure of the polyester backbone of coatings were synthesized. Out of both enzymes, only the cutinase was able to hydrolyze both model substrates while the larger substrate was hydrolyzed at a lower rate. The cutinase was also able to hydrolyze a coating (alkyd resin) both in suspension and as dried film. LC–MS analysis of the hydrolysis products released from the coating revealed the presence of oleic acid, its monoglyceride, phthalic acid and 2-((3-((2-((2,3-dihydroxypropoxy)carbonyl)benzoyl)oxy)-2-hydroxypropoxy)carbonyl)benzoic acid. These results indicate that the enzyme was able to hydrolyze the polyester backbone as well as to release fatty acid side chains. Consequently, enzymatic hydrolysis has a potential for the removal of coatings, their recycling or their functionalization.     

The Discovery and Structure-Activity Evaluation of (+)-Floyocidin B and Synthetic Analogs

Tuberculosis represents one of the ten most common courses of death worldwide and the emergence of multidrug-resistant M. tuberculosis makes the discovery of novel anti-tuberculosis active structures an urgent priority. Here, we show that (+)-floyocidin B representing the first example of a novel dihydroisoquinoline class of fungus-derived natural products, displays promising antitubercular hit properties. (+)-Floyocidin B was identified by activity-guided extract screening and its structure was unambiguously determined by total synthesis. The absolute configuration was deduced from a key synthesis intermediate by single crystal X-ray diffraction analysis. A hit series was generated by the isolation of further natural congeners and the synthesis of analogs of (+)-floyocidin B. Extensive biological and physicochemical profiling of this series revealed first structure-activity relationships and set the basis for further optimization and development of this novel antitubercular scaffold.