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91.
The production, survival and function of monocytes and macrophages are regulated by the macrophage colony-stimulating factor (M-CSF or CSF-1) through its tyrosine kinase receptor Fms. Binding of M-CSF results in Fms autophosphorylation on specific tyrosines that act as docking sites for intracellular signaling molecules containing SH2 domains. Using a yeast two-hybrid screen, we cloned a novel adaptor protein which we called 'Mona' for monocytic adaptor. Mona contains one SH2 domain and two SH3 domains related to the Grb2 adaptor. Accordingly, Mona interacts with activated Fms on phosphorylated Tyr697, which is also the Grb2-binding site. Furthermore, Mona contains a unique proline-rich region located between the SH2 domain and the C-terminal SH3 domain, and is apparently devoid of any catalytic domain. Mona expression is restricted to two hematopoietic tissues: the spleen and the peripheral blood mononuclear cells, and is induced rapidly during monocytic differentiation of the myeloid NFS-60 cell line in response to M-CSF. Strikingly, overexpression of Mona in bone marrow cells results in strong reduction of M-CSF-dependent macrophage production in vitro. Taken together, our results suggest an important role for Mona in the regulation of monocyte/macrophage development as controlled by M-CSF.  相似文献   
92.
A closed-form expression is obtained for pulse broadening in graded-index fibres with k2(r)=1?r2+?2r4+?+?nr2n. Pulse broadening for k2(r)=1?r2+0.615r4+70r6 and r<0.1 is 12 times smaller than for square-law fibres if material dispersion is neglected.  相似文献   
93.
Arnaud  J.A. 《Electronics letters》1972,8(22):541-542
A confusion is sometimes made in the literature between the mass-carrying momentum of a photon, which is inversely proportional to the refractive index of the medium in which it propagates, and the momentum taken up by an absorber located in a fluid, which is directly proportional to the refractive index of the fluid. The distinction between these two momenta is clarified by considering an artificial dielectric.  相似文献   
94.
A drier project necessitates the efficient formulation of the behaviour of product samples. When the temperature gap is great, the drying rate must make explicit the influence of the thnc air parameters : temperature, moisture, velocity. The case of the grape demonsnates that the adimensional expression formulated by Van Meel and Keey. must be completed in order to be adjusted to experiments.

The hot air drier model composed of the equations of conservation and thin layer drying rate can sometimes be simplified into a form of analytic integral equation around the drying rate. W e drying can be considered generally as adiabatic.

Two examples of grape driers are presented and show the value of simplified tools for the project. In a tunnel drier with a high air temperature one can speak of the celerity of a drying front which progress along the trolleys. In a short drier connected to an agricultural solar collector, the integration of the drying rate takes into account the variation of the meteorological data.  相似文献   
95.
Apparent total alpha1-antitrypsin deficiency: report of a case   总被引:1,自引:0,他引:1  
A 29-year-old female, with chronic renal failure and chronic bilateral emphysema, was admitted with severe uremia and septicemia secondary to multiple abscesses in the right kidney. Her condition improved after right nephrectomy. Pulmonary function studies showed marked obstructive and restrictive lung disease consistent witht the diagnosis of primary emphysema. On biochemical and histological examination, the liver was found to be normal. Alpha1-antitrypsin could not be demonstrated in the patient's serum at normal pH by any of the known techniques, but protein molecules with alpha1-antitrypsin antigencity were found at pH 4.8; this suggests a pH-dependent structural difference in alpha1-antitrypsin protein. Starch gel electrophoresis gave a multibanding pattern not previously described. A new form of apparent total alpha-1-antitrypsin deficiency is postulated.  相似文献   
96.
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98.
We study theoretically and experimentally the increase of normal incidence reflectivity generated by addition of a third material in the period of a standard periodic multilayer, for wavelengths in the range 20 to 40 nm. The nature and thickness of the three materials has been optimized to provide the best enhancement of reflectivity. Theoretical reflectivity of an optimized B4C/Mo/Si multilayer reaches 42% at 32 nm. B4C/Mo/Si multilayers have been deposited with a magnetron sputtering system and a reflectivity of 34% at 32 nm has been measured on a synchrotron radiation source.  相似文献   
99.
Arnaud Soury  Edouard Ngoya 《电信纪事》2005,60(11-12):1488-1506
Accurate and dynamic behavioral models of SSPAS become of prime importance in system level analysis and design of modern communication and detection systems. This paper describes a new method to characterize and reproduce nonlinear memory effects in behavioral models ofSspas. We highlight, in a first section, the detailed mathematical development, whose the starting point is the Volterra series expansion, and ends to the nonlinear impulse response notion. The new model extraction relies on envelope transient simulations or time-domain measurements of complex envelopes at externDut reference accesses. This modeling technique is simple and enables a good prediction of nonlinear memory effects and especially long term memory effects and nonlinear transient behaviors. Simulations and measurements based extractions of this model are presented through significant amplifier examples.  相似文献   
100.
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