Relative element levels in the paired samples of scalp hair and fingernails of patients from New Delhi

Specific elements are bioconcentrated in human hair and nails, which have unique advantages of application in population monitoring studies thereby, recognized as biological tools for disease diagnosis and prevention. However, investigations are meager for relative element profile in hair and nails of same subjects. In this study, hair and nails were analyzed to find effects of age, sex, smoking habit, diet, urban and rural exposure gradients, occupation, and health on element levels. Scalp hair and fingernails were sampled along with a questionnaire from urban and rural subjects of New Delhi; patients of hypertension, coronary heart disease, and diabetes were identified clinically. Cadmium, chromium, copper, nickel, lead and zinc concentrations were determined by AAS in both the samples; CRM (human hair powder) analysis showed acceptable precision and accuracy in element measurement. In comparison to controls, Cr-H and Zn-H levels were lower respectively in female hypertensive and total hypertensive subjects, whereas, Zn-N and Cu-N were lower respectively in total CHD and diabetic subjects, and hypertensive and CHD urban subjects. Cd concentrations were higher in both the samples of tobacco smoking rural subjects than that of non-smokers. Farmers had lower Pb-H than rural businessmen did. Cr, Cu, Ni, and Zn concentrations were different due to rural and urban gradient but not to the influence of age, sex, and diet. Pb value was alone correlated between the paired samples. Thus, higher Cd levels in the smokers and lower Cr, Cu and Zn levels in the patients were observed.     

The label-free unambiguous detection and symbolic display of single nucleotide polymorphisms on DNA origami

Single nucleotide polymorphisms (SNPs) are the most common genetic variation in the human genome. Kinetic methods based on branch migration have proved successful for detecting SNPs because a mispair inhibits the progress of branch migration in the direction of the mispair. We have combined the effectiveness of kinetic methods with atomic force microscopy of DNA origami patterns to produce a direct visual readout of the target nucleotide contained in the probe sequence. The origami contains graphical representations of the four nucleotide alphabetic characters, A, T, G and C, and the symbol containing the test nucleotide identity vanishes in the presence of the probe. The system also works with pairs of probes, corresponding to heterozygous diploid genomes.     

Blood levels of cadmium,copper, lead and zinc in children in a British Columbia community

The levels of Cd, Cu, Pb and Zn were measured in duplicate whole blood samples of 946 apparently normal children ranging in age from 2 years to 12 years and living in Kamloops, British Columbia, Canada. The metals were determined using atomic absorption spectrometry: graphite furnace AAS for Cd and Pb, and flame AAS for Cu and Zn. The median and extreme values expressed as milligram of metal per litre of whole blood for the total population were: Cd ? 0.0005, Cu 1.11 (0.69–1.78), Pb 0.112 (0.020–0.400), and Zn 4.30 (2.10–6.53). No significant variations were noted in the median metal values either with age or with sex. The median Cu, Pb and Zn values were within the normal range.     

Complex two-unit system with preventive maintenance

A two-unit warm standby redundant system with repair and preventive maintenance is considered. The pdf of the life time of a unit while in standby is assumed to be Erlangian. The pdfs of all the other random variables are arbitrary. Identifying suitable regeneration points, expressions for the Laplace transforms of the availability and reliability of the system are derived.     

An investigation of the origin of the main electron trap in GaAs

The origin of the main electron trap (0.83 eV) in GaAs is investigated by creating conditions to favour the formation of Ga-vacancy-oxygen complex in the material. Two specific schemes have been used, (1) Liquid phase epitaxial (LPE) growth of the material at high temperatures (≈1000°C) with oxygen doping and (2) Electron bombardment of LPE material and subsequent annealing. The traps have been characterised by transient capacitance technique. The results show that the main electron trap cannot be produced by either of the schemes thereby implying that a complex involving Ga-vacancy and oxygen may not be responsible for the trap.     

The Davidson method as an alternative to power iterations for criticality calculations

The Davidson method is implemented within the neutron transport core solver parafish to solve k-eigenvalue criticality transport problems. The parafish solver is based on domain decomposition. It uses spherical harmonics (P_N method) for angular discretization, and non-conforming finite elements for spatial discretization. The Davidson method is compared to the traditional power iteration method in this context.     

Synthesis and properties of organotin epoxy polymers from tri-n-butyltin esters of ω - amino acids

Structure-property relationships in a series of thermoset organotin polymers have been investigated. The tri-n-butyltin esters of glycine, 4-aminobutanoic, 6-aminohexanoic, and 11-aminoundecanoic acids were synthesized and reacted with diepoxides to prepare prepolymers carrying epoxide end groups. The prepolymers were crosslinked by diethylenetriamine or metaphenylenediamine. Similar epoxy network polymers were prepared directly from the tributyltin ester of 3,5-diaminobenzoic acid which was also synthesized. The strength, moduli, toughness, glass transition and dynamic mechanical response of the polymers were investigated, and correlated with structural changes introduced in the network. The results establish the utility of the adopted synthesis schemes in exercising considerable control over the bulk polymer properties, and consequently, in modifying the controlled release of organotin groups from the crosslinked network.     

Metabolism of linolenic acid in developing brain: I. Incorporation of radioactivity from 1-14C linolenic acid into brain fatty acids

Twelve-thirteen day old rats were given 1-¹⁴C linolenic acid by intraperitoneal injection. Fatty acids were isolated from the brains of animals sacrificed at the end of 8 and 48 hr and 15 and 45 days. Eight hr after the tracer, radioactivity was found neither in 18∶3 nor its endproduct, 22∶6, and palmitate was the most highly radioactive component. At longer intervals, 22∶6 seemed to retain much of the radioactivity, whereas palmitate showed a precipitous decline in radioactivity. Initial oxidation of linolenate and sparing of the linolenate complexed with polar lipids are discussed.     

Induced liquid phase mixing due to bubble motion at low gas velocity

Liquid phase mixing induced by gas bubbles at low gas velocities was studied experimentally. An experimental technique based on the principle of spectrophotometry was developed and applied in the experimental work. Experimental evidence suggests that the mixing phenomenon can be described as a diffusive process characterized by an effective diffusivity which is found to be a linear function of superficial gas velocity.     

Age Replacement In Simple Systems With Increasing Loss Functions

Some age replacement policies are investigated and conditions for the unique existence of an optimum policy are derived. The optimum policy is the one which minimizes the expected cost per unit time over an infinite time span or maximizes the proportion of time during which the system is in operation. Losses have been expressed through increasing operating cost, if the objective is to minimize the expected total cost per unit time and through increasing renewal times if the objective is to maximize the availability of the system.