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91.
Ken Namatame Yutaka Kukita Isao Takeshita Yoshimichi Shimoda 《Nuclear Engineering and Design》1983,75(1):5-11
An analytical method is developed for solving the fluid-structure interactions (FSI) associated with hydraulic transients in the BWR pressure suppression pool during a hypothetical loss-of-coolant accident. The present method assumes inviscid and infinitesimal motion of pool water for which the governing fluid-dynamic equation reduces to a linear wave equation with inhomogeneous boundary conditions of flexible pool boundaries. The present method is applied to quantitative evaluation of the FSI effect on test data obtained from a large scale pressure suppression test which was performed to investigate the pressure oscillations in the pool induced by unstationary steam condensation. 相似文献
92.
Tensile strength characteristics of reinforced fusion-spliced optical fiber are important to establish a stable optical line in the field. This paper describes theoretical and experimental results on the strength of reinforced fiber. The stripped fiber strengths of fused splice parts and nonheated parts were measured and were found to be different. When a tension is applied to the reinforced fiber, the induced fiber stress is evaluated along its axis. The strength characteristics of reinforced fiber were investigated, based on the stress distribution and the different strengths of fusion-spliced fiber. It is reported that the strength after reinforcement can be predicted and that the strength depends on the adhesive modulus of rigidity. The adhesive design is also presented to obtain necessary strength of reinforced fiber under an allowable failure probability. 相似文献
93.
Naohiro Matsumura Asako Miura Yasufumi Shibanai Yukio Ohsawa Toyoaki Nishida 《AI & Society》2005,19(1):84-92
2channel is the most popular online-community site in Japan, where millions of people are discussing or chitchatting about various topics. The communication in 2channel shows dynamic social phenomena such as positive/negative communication, polarization of opinions, slander called flaming, etc. In this paper, we assume the existence of underlying prevailing structures that motivate peoples participation. The structural equation model of 2channel, which is obtained on the basis of observed collective actions about peoples thought, emotions and motivations, shows the uniformity and regularities in complex human communication in 2channel. 相似文献
94.
The identification of protein-protein interaction sites is essential for the mutant design and prediction of protein-protein networks. The interaction sites of residue units were predicted using support vector machines (SVM) and the profiles of sequentially/spatially neighboring residues, plus additional information. When only sequence information was used, prediction performance was highest using the feature vectors, sequentially neighboring profiles and predicted interaction site ratios, which were calculated by SVM regression using amino acid compositions. When structural information was also used, prediction performance was highest using the feature vectors, spatially neighboring residue profiles, accessible surface areas, and the with/without protein interaction sites ratios predicted by SVM regression and amino acid compositions. In the latter case, the precision at recall = 50% was 54-56% for a homo-hetero mixed test set and >20% higher than for random prediction. Approximately 30% of the residues wrongly predicted as interaction sites were the closest sequentially/spatially neighboring on the interaction site residues. The predicted residues covered 86-87% of the actual interfaces (96-97% of interfaces with over 20 residues). This prediction performance appeared to be slightly higher than a previously reported study. Comparing the prediction accuracy of each molecule, it seems to be easier to predict interaction sites for stable complexes. 相似文献
95.
96.
The crystalline structure of decrystallized cotton, prepared by partial cyanoethylation with the use of sodium hydroxide aqueous solution and acrylonitrile, was examined by x-ray and IR data, in connection with such fabric properties as moisture regain. It was found that the moisture regain of the cotton fabric first increased, passed through a maximum at about 6 mole-% of cyanoethylation, and then slightly decreased with increasing degree of cyanoethylation. The increase of moisture regain in the region of the lower degree of cyanoethylation was well related to the decrease in the crystallinity of cotton. The x-ray diffraction studies revealed that the distension and disorder of the unit cell occurred primarily in the direction perpendicular to the (101) crystal plane as cyanoethylation proceeded. 相似文献
97.
The organic solvent tolerance of Escherichia coli was measured under conditions in which OmpF levels were controlled by various means as follows: alteration of NaCl concentration in the medium, transformation with a stress-responsive gene (marA, robA, or soxS), or disruption of the ompF gene. It was shown that solvent tolerance of E. coli did not depend upon OmpF levels in the membrane. 相似文献
98.
Combined natural convection and radiation heat transfer characteristics in a vertical porous layer with a hexagonal honeycomb core were investigated experimentally. The temperature distributions on the honeycomb core wall and the combined heat transfer rates through the porous layer were measured. The measurements of the heat transfer were accomplished using the guarded hot plate method. The honeycomb core wall was made of paper and large-mesh foamed resins were inserted into the honeycomb enclosures. The measurements were performed by varying the radiation parameters between 0.5 and 0.65, varying the temperature ratios between 0.01 and 0.1, and varying the Darcy-Rayleigh numbers between 5 and 80, and for a fixed aspect ratio H/L = 1. The experimental results for Nusselt numbers agreed well with our available numerical results. © 1999 Scripta Technica, Heat Trans Asian Res, 28(4): 295–306, 1999 相似文献
99.
Shin Takasawa Mai Makino Tomoko Uchiyama Akiyo Yamauchi Sumiyo Sakuramoto-Tsuchida Asako Itaya-Hironaka Yoshinori Takeda Keito Asai Ryogo Shobatake Hiroyo Ota 《International journal of molecular sciences》2022,23(15)
Sleep apnea syndrome (SAS) is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia, IH), and it is a risk factor for cardiovascular disease (CVD) and insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress and CVD remain elusive. We exposed rat H9c2 and mouse P19.CL6 cardiomyocytes to experimental IH or normoxia for 24 h to analyze the mRNA expression of the components of Cd38-cyclic ADP-ribose (cADPR) signaling. We found that the mRNA levels of cluster of differentiation 38 (Cd38), type 2 ryanodine receptor (Ryr2), and FK506-binding protein 12.6 (Fkbp12.6) in H9c2 and P19.CL6 cardiomyocytes were significantly decreased by IH, whereas the promoter activities of these genes were not decreased. By contrast, the expression of phosphatase and tensin homolog deleted from chromosome 10 (Pten) was upregulated in IH-treated cells. The small interfering RNA for Pten (siPten) and a non-specific control RNA were introduced into the H9c2 cells. The IH-induced downregulation of Cd38, Ryr2, and Fkbp12.6 was abolished by the introduction of the siPten, but not by the control RNA. These results indicate that IH stress upregulated the Pten in cardiomyocytes, resulting in the decreased mRNA levels of Cd38, Ryr2, and Fkbp12.6, leading to the inhibition of cardiomyocyte functions in SAS patients. 相似文献
100.
Takemichi Fukasawa Asako Yoshizaki-Ogawa Atsushi Enomoto Kiyoshi Miyagawa Shinichi Sato Ayumi Yoshizaki 《International journal of molecular sciences》2022,23(15)
Palmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate and acquired immunity are involved. In particular, based on the tonsils and basic experiments, it has been assumed that T and B cells are involved in its pathogenesis. In addition, the results of clinical trials have suggested that IL-23 is closely related to the pathogenesis. This review describes PPP and the genetic background, the factors involved in the onset and exacerbation of disease and its relation to the molecular mechanism. In addition, we describe the usefulness of biological therapy and its implications in relation to the importance in pathology, the pathogenesis of PPP, the importance of the role of the IL-23–Th17 axis and IL-36 in PPP. Furthermore, we describe an animal experimental model of PPP, the efficacy and mechanism of action of guselkumab, an anti-IL-23 antibody, the latest research, and finally the possibility for it to be effective for other autoimmune diseases. 相似文献