Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery

The coevolution of genomics and proteomics has led to advancements in the field of diagnosis and molecular mechanisms of disease. Proteomics is now stepping into the field of obstetrics, where early diagnosis of pregnancy complication such as preeclampsia (PE) is imperative. PE is a multifactorial disease characterized by hypertension with proteinuria, which is a leading cause of maternal and neonatal morbidity and mortality occurring in 5-7% of pregnancies worldwide. This review discusses the probable molecular mechanisms that lead to PE and summarizes the proteomics research carried out in understanding the pathogenicity of PE, and for identifying the candidate biomarker for diagnosis of the disease.     

A novel dynamic pricing scheme for contributing peers in the VoD system

In this paper we have proposed a dynamic pricing scheme for the contributing peers in the Video on Demand (VoD) system. The scheme provides an effective mechanism to maximize the profit through the residual resources of the contributing peers. A utilization function is executed for each contributing peer to estimate the utility factor based on the parameters such as initial setup cost, holding cost, chaining cost and salvage cost. In this paper, we urge an effective dynamic pricing algorithm that efficiently utilizes a range of parameters with a varying degree of complexity. The key findings of the algorithm are (i) each contributing peers are benefitted by the monetary based on its resource contributions to the VoD system and (ii) a high degree of social optimum is established by proficiently aggregating the contributing peer’s resources with the overall resources of the VoD system. We validate our claim by simulating the proposed dynamic pricing scheme with other standard pricing schemes such as altruism, cost model and game theory perspective. The result of our dynamic pricing scheme shows the best utility factor than other standard pricing schemes.     

Performance Tuning and Reliability Analysis of the Electrostatically Configured Nanotube Tunnel FET with Impact of Interface Trap Charges

Silicon - This paper examines, an electrostatically configured Nano-Tube Tunnel Field-Effect Transistor (ED-NTTFET). During the fabrication process, different charges such as fixed charge, oxide...     

A Numerical Investigation of Heat Suppression in HEMT for Power Electronics Application

Silicon - In this paper, AlGaN/GaN High Electron Mobility Transistor (HEMT) with stacked passivation (Diamond/SiN) is proposed and investigated. The implementation of stacked passivation in HEMT...     

An efficient new method for the detection of QRS in electrocardiogram

A simple and efficient new method for QRS detection in Electrocardiogram (ECG) is proposed in this paper. Initially data is preprocessed using two stage median filter for removing baseline drift. The second stage enhances the peaks of ECG wave components by using sixth power of signal. The next stage identifies the QRS complex by taking a variable window size. The detection sensitivity (Se) and positive predictivity (+P) of CSE (Common Standards for Quantitative Electrocardiography) measurement database, MIT/BIH (Massachusetts Institute of Technology/Beth Israel Hospital) Arrhythmia database, European ST-T database and QT database are Se 99.51 & +P 99.69%, Se 99.21 & +P 99.34%, Se 99.53 & +P 99.72% and Se 99.87 & +P 99.95% respectively. These four standard databases used to perform QRS detection considered 368 cases, tested 1,006,168 beats and achieved overall average sensitivity 99.52% and positive predictivity 99.69%. The MIT/BIH Noise Stress Test Database also tested by proposed method.     

Formation of Nanocrystalline Calcia by the Decomposition of Calcite

Formation of nanocrystalline calcia from calcite has been studied in situ via transmission electron microscopy. The crystallographic transformation occurred via two mechanisms: the first is by distortion of the cleaved rhombohedron of calcite, formed by {104} planes in hexagonal coordinates, into a cube. This produced a microstructure of oriented, elongated nanocrystals of calcia with planar boundaries. In the second mechanism, the micrometer-sized parent calcite particles broke up into nano-sized grains as the decomposition began, leading to irregularly shaped, randomly oriented nanocrystals of calcia.     

Review of specialty PVC resins

World consumption of PVC was around 25 MM MT (55 billion pounds) in year 2001, second only to that of low density polyethylene. Only 10% of the PVC produced is classified as specialty PVC resins, while the other 90% is referred to as general purpose (GP) commodity resins. This paper tries to define what specialty PVC resins are, how they are produced, and their markets, applications, fabrication processes, and compounding as compared to those of GP resins.     

Studies on polyblends of poly(vinyl chloride) and acrylonitrile-butadiene-styrene terpolymer

Blends of poly (vinyl chloride) (PVC) and acrylonitrile-butadiene styrene (ABS) terpolymer were prepared in different ratios by a melt blending technique. ABS containing three different levels of rubber content were used. A quantitative assessment of ABS in PVC/ABS blends has been shown by infrared studies. ABS content has been shown as the presence of the characteristic acrylonitrile peak. Differential scanning calorimetry (DSC) studies have been carried out to study the glass transition (T_g) behavior of the blends. Two T_g values corresponding to PVC and styrene-acrylonitrile (SAN) copolymer have been observed. Thermogravimetric analysis (TGA) reveals a significant improvement in thermal stability of these blends as compared to PVC. Mechanical properties show a significant increase in the impact strength which is related to rubber content of the ABS used. Morphological studies have been carried out by scanning electron microscopy which support the observation that an increase in rubber content results in greater ductility.     

Polymeric sodium alginate interpenetrating network beads for the controlled release of chlorpyrifos

Novel polymeric sodium alginate (Na‐Alg) interpenetrating network (IPN) beads have been prepared by crosslinking Na‐Alg blend with gelatin (GE) or egg albumin (EA) using glutaraldehyde (GA) as the crosslinking agent. These beads were used for the controlled release of chlorpyrifos. The swelling experiments were performed in water at different temperatures, and these data were used to calculate the molecular mass (M_C) between crosslinks as well as diffusion coefficients. Diffusion coefficients calculated from desorption data were lower by about two orders of magnitude than those calculated from sorption results. Higher values of M_C were obtained for the gelatin‐based IPNs than the neat Na‐Alg and egg albumin‐based matrices. Size of the beads did not vary significantly either by the network or by increasing the exposure time to the crosslinking agent. The scanning electron microscopy (SEM) was used to understand the surface characteristics of the beads. Differential scanning calorimetry (DSC) indicated a molecular level dispersion of chlorpyrifos in the polymer matrix. The percentage entrapment efficiency showed a dependence on the type of network polymer as well as time of exposure to the crosslinking agent. The encapsulation efficiency decreased with an increase in time of exposure to the crosslinking agent. In vitro release experiments have been performed to follow the release kinetics of chlorpyrifos from the matrices. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 911–918, 2002     

Changes in liver lipids after administration of 2-decanoylamino-3-morpholinopropiophenone and chlorpromazine

The enzyme which forms glucocerebroside, ceramide: UDP-glucose glucosyltransferase, is inactivated in vitro by a cationic analog of cerebroside, 2-decanoylamino-3-morpholinopropiophenone. A study of the inhibitor using intraperitoneal injection into young mice showed that the level of the enzyme activity in liver was appreciably lowered between 3 and 6 hr after injection. The activity increased subsequently, overshooting the normal level within 24 hr by about 20%, then returning to normal within the next 24 hr. Additional effects observed in liver were an increase in lipid content (primarily in the triglyceride fraction and ceramides) and a decrease in the glucocerebroside level. Body temperature dropped rapidly. Markedly similar effects were produced by injecting chlorpromazine, which was tried in order to reduce the hyperirritability and inhibitory effects on monoamine oxidase previously demonstrated by the glucosyltransferase inhibitor. Chlorpromazine did indeed block the hyperirritability and resulted in enhancement of the keto amine's effects on the enzyme and lipids. It is possible that the two drugs in combination would be helpful in ameliorating the symptoms due to the cerebroside accumulation that occurs in Gaucher disease. Diazepam also produced a reduced level of glucosyltransferase. A color reaction for chlorpromazine, possibly suitable for quantitative determination in tissues, was accidentally discovered.