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31.
Yuriko Kaino Kenichi Kurihara Aya Shuto Hiroshi Mizuno Satoko Asaoka Takehisa Ishida Kenji Takagi Isao Takahashi Hirohisa Amago Taichi Takeuchi Asuka Tejima Maho Watanabe Yuki Oishi Takahiro Kamei Kazumasa Nomoto 《Journal of the Society for Information Display》2019,27(5):295-303
We have developed a laser‐addressed full‐color photographic quality rewritable sheet. The sheet was composed of a vertically stacked Cyan/Magenta/Yellow‐thermochromic system with a mixture of leuco dyes, developers and photothermal conversion agents in a polymer matrix. The sheet was simply manufactured by roll‐to‐roll (R2R) processes. Writing and erasing were performed by scan of near‐infrared laser light. It achieved full‐color photographic quality images with a wide color gamut with 70% coverage of the Specifications for Web Offset Publications (SWOP) standards and a high resolution of 426 ppi. Clear rewritability has also been confirmed. Non‐contact laser writing has other advantages in that it can create an image under a protection film, and it has form factor flexibility. We have developed a reliability model for high‐temperature storage and a light fastness test. This model showed a good agreement with experimental data, and the lifetime of an image was estimated to be over 8 years under ambient conditions. This technology will create applications for on‐demand rewritable image design while saving power and reducing the use of paper, which will eventually contribute to a sustainable society. 相似文献
32.
Kentaro Torisawa Stijn De Saeger Jun’ichi Kazama Asuka Sumida Daisuke Noguchi Yasunori Kakizawa Masaki Murata Kow Kuroda Ichiro Yamada 《New Generation Computing》2010,28(3):217-236
This paper introduces the TORISHIKI-KAI project, which aims to construct a million-word-scale semantic network from the Web
using state of the art knowledge acquisition methods. The resulting network can be browsed as a Web search directory, and
we show that the directory is useful for finding “unknown unknowns” — in the infamous words of D.H. Rumsfeld: things “we don't know we don't know.” Because typically we have no way to look for information we don't even know is missing, a crucial characteristic of unknown
unknowns is that they are very difficult to discover through keyword-based Web search. Some examples of the unknown unknowns
we have found include unexpected troubles associated with commercial products, surprising new combinations of ingredients
in new recipes, unexpected tools or methods for commiting suicide, and so on. We expect such information to be useful for
risk management, innovation support, and the detection of harmful information on the Web. 相似文献
33.
Jiann-Horng Yeh Kuo-Ching Wang Asuka Kaizaki Jonathan W. Lee Han-Chi Wei Michelle A. Tucci Norma B. Ojeda Lir-Wan Fan Lu-Tai Tien 《International journal of molecular sciences》2021,22(12)
Previous studies have demonstrated that pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, inhibits ischemia-induced brain injury. The present study was conducted to examine whether pioglitazone can reduce impairment of behavioral deficits mediated by inflammatory-induced brain white matter injury in neonatal rats. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 2 mg/kg) was administered to Sprague–Dawley rat pups on postnatal day 5 (P5), and i.p. administration of pioglitazone (20 mg/kg) or vehicle was performed 5 min after LPS injection. Sensorimotor behavioral tests were performed 24 h after LPS exposure, and changes in biochemistry of the brain was examined after these tests. The results show that systemic LPS exposure resulted in impaired sensorimotor behavioral performance, reduction of oligodendrocytes and mitochondrial activity, and increases in lipid peroxidation and brain inflammation, as indicated by the increment of interleukin-1β (IL-1β) levels and number of activated microglia in the neonatal rat brain. Pioglitazone treatment significantly improved LPS-induced neurobehavioral and physiological disturbances including the loss of body weight, hypothermia, righting reflex, wire-hanging maneuver, negative geotaxis, and hind-limb suspension in neonatal rats. The neuroprotective effect of pioglitazone against the loss of oligodendrocytes and mitochondrial activity was associated with attenuation of LPS-induced increment of thiobarbituric acid reactive substances (TBARS) content, IL-1β levels and number of activated microglia in neonatal rats. Our results show that pioglitazone prevents neurobehavioral disturbances induced by systemic LPS exposure in neonatal rats, and its neuroprotective effects are associated with its impact on microglial activation, IL-1β induction, lipid peroxidation, oligodendrocyte production and mitochondrial activity. 相似文献
34.
So Masaki Rei Yoshimoto Daisuke Kaida Asuka Hata Takayuki Satoh Mutsuhito Ohno Naoyuki Kataoka 《International journal of molecular sciences》2015,16(2):3705-3721
In eukaryotes, pre-mRNA splicing is an essential step for gene expression. We have been analyzing post-splicing intron turnover steps in higher eukaryotes. Here, we report protein interaction between human Debranching enzyme 1 (hDbr1) and several factors found in the Intron Large (IL) complex, which is an intermediate complex of the intron degradation pathway. The hDbr1 protein specifically interacts with xeroderma pigmentosum, complementeation group A (XPA)-binding protein 2 (Xab2). We also attempted to identify specific interactors of hDbr1. Co-immunoprecipitation experiments followed by mass spectrometry analysis identified a novel protein as one of the specific interactors of hDbr1. This protein is well conserved among many species and shows the highest similarity to yeast Drn1, so it is designated as human Dbr1 associated ribonuclease 1 (hDrn1). hDrn1 directly interacts with hDbr1 through protein–protein interaction. Furthermore, hDrn1 shuttles between the nucleus and the cytoplasm, as hDbr1 protein does. These findings suggest that hDrn1 has roles in both the nucleus and the cytoplasm, which are highly likely to involve hDbr1. 相似文献
35.
Khoeurn Kimleang Sasaki Asuka Tomiyama Shingo Igarashi Toshifumi 《Mine Water and the Environment》2019,38(1):119-129
Mine Water and the Environment - This paper addresses the mechanism of acid mine drainage generation in tailings from an abandoned mine site and predicts the evolution of zinc (Zn), copper (Cu),... 相似文献
36.
Shin-ichi Ohkoshi Marie Yoshikiyo Kenta Imoto Kosuke Nakagawa Asuka Namai Hiroko Tokoro Yuji Yahagi Kyohei Takeuchi Fangda Jia Seiji Miyashita Makoto Nakajima Hongsong Qiu Kosaku Kato Takehiro Yamaoka Masashi Shirata Kenji Naoi Koichi Yagishita Hiroaki Doshita 《Advanced materials (Deerfield Beach, Fla.)》2020,32(48):2004897
In the era of Big Data and the Internet of Things, data archiving is a key technology. From this viewpoint, magnetic recordings are drawing attention because they guarantee long-term data storage. To archive an enormous amount of data, further increase of the recording density is necessary. Herein a new magnetic recording methodology, “focused-millimeter-wave-assisted magnetic recording (F-MIMR),” is proposed. To test this methodology, magnetic films based on epsilon iron oxide nanoparticles are prepared and a focused-millimeter-wave generator is constructed using terahertz (THz) light. Irradiating the focused millimeter wave to epsilon iron oxide instantly switches its magnetic pole direction. The spin dynamics of F-MIMR are also calculated using the stochastic Landau–Lifshitz–Gilbert model considering all of the spins in an epsilon iron oxide nanoparticle. In F-MIMR, the heat-up effect of the recording media is expected to be suppressed. Thus, F-MIMR can be applied to high-density magnetic recordings. 相似文献
37.
Yurika Nakagawa-Saito Shinichi Saitoh Yuta Mitobe Asuka Sugai Keita Togashi Shuhei Suzuki Chifumi Kitanaka Masashi Okada 《International journal of molecular sciences》2022,23(15)
Cancer stem cells (CSCs) are in general characterized by higher resistance to cell death and cancer therapies than non-stem differentiated cancer cells. However, we and others have recently revealed using glioma stem cells (GSCs) as a model that, unexpectedly, CSCs have specific vulnerabilities that make them more sensitive to certain drugs compared with their differentiated counterparts. We aimed in this study to discover novel drugs targeting such Achilles’ heels of GSCs as anti-GSC drug candidates to be used for the treatment of glioblastoma, the most therapy-resistant form of brain tumors. Here we report that domatinostat (4SC-202), a class I HDAC inhibitor, is one such candidate. At concentrations where it showed no or minimal growth inhibitory effect on differentiated GSCs and normal cells, domatinostat effectively inhibited the growth of GSCs mainly by inducing apoptosis. Furthermore, GSCs that survived domatinostat treatment lost their self-renewal capacity. These results suggested that domatinostat is a unique drug that selectively eliminates GSCs not only physically by inducing cell death but also functionally by inhibiting their self-renewal. Our findings also imply that class I HDACs and/or LSD1, another target of domatinostat, may possibly have a specific role in the maintenance of GSCs and therefore could be an attractive target in the development of anti-GSC therapies. 相似文献
38.
39.
Asuka Nakano Naozumi Teramoto Guoping Chen Yoshiko Miura Mitsuhiro Shibata 《应用聚合物科学杂志》2010,118(4):2284-2290
Complex gel materials of Type I collagen and aluminosilicate containing imogolite nanofibers were prepared as opaque gel by mixing an acidic fine dispersion of aluminosilicate with an acidic solution of collagen. The product was stained blue by Coomassie Brilliant Blue (CBB), indicating that the gel contained collagen. A white sponge was obtained after lyophilization of the complex gel. Elemental analysis revealed that the complex contains C, H, N, Al, and Si atoms; and the compositional ratio of aluminosilicate/collagen (w/w) was calculated as 0.75 for the complex gel when aluminosilicate was mixed with an equal quantity of collagen. Transmission electron microscope (TEM) observation showed that aluminosilicate nanofibers were homogeneously distributed in the collagen matrix. The thermogravimetric analysis (TGA) curve of the complex was not a simple summation of each components, and especially, the weight loss step corresponding to detachment of the adsorbed water observed in aluminosilicate became difficult to distinguish, suggesting that the adsorbed water was removed in the complexation. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 相似文献
40.
Moran Aviv Dana Cohen-Gerassi Asuka A. Orr Rajkumar Misra Zohar A. Arnon Linda J. W. Shimon Yosi Shacham-Diamand Phanourios Tamamis Lihi Adler-Abramovich 《International journal of molecular sciences》2021,22(17)
Supramolecular hydrogels formed by the self-assembly of amino-acid based gelators are receiving increasing attention from the fields of biomedicine and material science. Self-assembled systems exhibit well-ordered functional architectures and unique physicochemical properties. However, the control over the kinetics and mechanical properties of the end-products remains puzzling. A minimal alteration of the chemical environment could cause a significant impact. In this context, we report the effects of modifying the position of a single atom on the properties and kinetics of the self-assembly process. A combination of experimental and computational methods, used to investigate double-fluorinated Fmoc-Phe derivatives, Fmoc-3,4F-Phe and Fmoc-3,5F-Phe, reveals the unique effects of modifying the position of a single fluorine on the self-assembly process, and the physical properties of the product. The presence of significant physical and morphological differences between the two derivatives was verified by molecular-dynamics simulations. Analysis of the spontaneous phase-transition of both building blocks, as well as crystal X-ray diffraction to determine the molecular structure of Fmoc-3,4F-Phe, are in good agreement with known changes in the Phe fluorination pattern and highlight the effect of a single atom position on the self-assembly process. These findings prove that fluorination is an effective strategy to influence supramolecular organization on the nanoscale. Moreover, we believe that a deep understanding of the self-assembly process may provide fundamental insights that will facilitate the development of optimal amino-acid-based low-molecular-weight hydrogelators for a wide range of applications. 相似文献