Rapid and multimodal <Emphasis Type="Italic">in vivo</Emphasis> bioimaging of cancer cells through <Emphasis Type="Italic">in situ</Emphasis> biosynthesis of Zn&;Fe nanoclusters

Early diagnosis remains highly important for efficient cancer treatment,and hence,there is significant interest in the development of effective imaging strategies.This work reports a new multimodal bioimaging method for accurate and rapid diagnosis of cancer cells by introducing aqueous Fe2+ and Zn2+ ions into cancer cells (i.e.,HeLa,U87,and HepG2 cancer cells).We found that the biocompatible metal ions Fe2+ and Zn2+ forced the cancer cells to spontaneously synthesize fluorescent ZnO nanoclusters and magnetic Fe3O4 nanoclusters.These clusters could then be used for multimodal cancer imaging by combining fluorescence imaging with magnetic resonance imaging and computed tomography imaging.Meanwhile,for normal cells (i.e.,L02) and tissues,neither fluorescence nor any other obvious difference could be detected between preand post-injection.This multimodal bioimaging strategy based on the in situ biosynthesized Zn&Fe oxide nanoclusters might therefore be useful for early cancer diagnosis and therapy.     

In situ trapped high-density single metal atoms within graphene: Iron-containing hybrids as representatives for efficient oxygen reduction

Nano Research - Atomically dispersed catalysts have attracted attention in energy conversion applications because their efficiency and chemoselectivity for special catalysis are superior to those...     

Quantum Inspired Broadband Photonic Absorber: Potential Application as Solar Sail along with Mobility Analysis

Electromagnetic wideband absorption is still perceived as a critical and formidable challenge to address with an unambiguous photonic absorber. Subwavelength metamaterial (MM) unit cells with unique and controlled features have recently gained considerable interest. However, meta-atoms, generated using a quantum-inspired pattern distribution, are underwhelming in existing literature to design photonic absorbers and their potential application to manufacture solar sails is still quite uncommon. In this article, to create a flexible, polarization-insensitive, ultrathin, and broadband MM absorber, quantum interference pattern-inspired design is utilized. Herein, a novel approach to fabricating solar sails for the space exploration incorporates the proposed broadband photonic absorber rather than conventional reflectors. The quantum-inspired meta-absorber (QIMA) exhibits an absorption of over 91% for the visible domain, i.e., 380–800 nm under a conventional plane-polarized source. It is shown in the study that broadband absorbers are almost equivalent to excellent reflectors to design the solar sails in terms of the time-averaged force calculated by utilizing the Maxwell stress tensor method. Thus, the QIMA has the potential to be a viable alternative to reflectors in the design of futuristic solar sails for space exploration. The interference theory model is also utilized to assure the dependability of calculated data, and additionally, the standard AM1.5 solar spectrum is utilized to demonstrate the QIMA's solar-harvesting potentiality.     

An Improved Hybrid Indoor Positioning Algorithm via QPSO and MLP Signal Weighting

Accurate location or positioning of people and self-driven devices in large indoor environments has become an important necessity The application of increasingly automated self-operating moving transportation units, in large indoor spaces demands a precise knowledge of their positions. Technologies like WiFi and Bluetooth, despite their low-cost and availability, are sensitive to signal noise and fading effects. For these reasons, a hybrid approach, which uses two different signal sources, has proven to be more resilient and accurate for the positioning determination in indoor environments. Hence, this paper proposes an improved hybrid technique to implement a fingerprinting based indoor positioning, using Received Signal Strength information from available Wireless Local Area Network access points, together with the Wireless Sensor Networks technology. Six signals were recorded on a regular grid of anchor points, covering the research space. An optimization was performed by relative signal weighting, to minimize the average positioning error over the research space. The optimization process was conducted using a standard Quantum Particle Swarm Optimization, while the position error estimate for all given sets of weighted signals was performed using a Multilayer Perceptron (MLP) neural network. Compared to our previous research works, the MLP architecture was improved to three hidden layers and its learning parameters were finely tuned. These experimental results led to the 20% reduction of the positioning error when a suitable set of signal weights was calculated in the optimization process. Our final achieved value of 0.725 m of the location incertitude shows a sensible improvement compared to our previous results.     

Effectiveness of Deep Learning Models for Brain Tumor Classification and Segmentation

A brain tumor is a mass or growth of abnormal cells in the brain. In children and adults, brain tumor is considered one of the leading causes of death. There are several types of brain tumors, including benign (non-cancerous) and malignant (cancerous) tumors. Diagnosing brain tumors as early as possible is essential, as this can improve the chances of successful treatment and survival. Considering this problem, we bring forth a hybrid intelligent deep learning technique that uses several pre-trained models (Resnet50, Vgg16, Vgg19, U-Net) and their integration for computer-aided detection and localization systems in brain tumors. These pre-trained and integrated deep learning models have been used on the publicly available dataset from The Cancer Genome Atlas. The dataset consists of 120 patients. The pre-trained models have been used to classify tumor or no tumor images, while integrated models are applied to segment the tumor region correctly. We have evaluated their performance in terms of loss, accuracy, intersection over union, Jaccard distance, dice coefficient, and dice coefficient loss. From pre-trained models, the U-Net model achieves higher performance than other models by obtaining 95% accuracy. In contrast, U-Net with ResNet-50 outperforms all other models from integrated pre-trained models and correctly classified and segmented the tumor region.     

Intelligently tuned wavelet parameters for GPS/INS error estimation

This paper presents a new algorithm for de-noising global positioning system (GPS) and inertial navigation system (INS) data and estimates the INS error using wavelet multi-resolution analysis algorithm (WMRA)-based genetic algorithm (GA) with a well-designed structure appropriate for practical and real time implementations because of its very short training time and elevated accuracy. Different techniques have been implemented to de-noise and estimate the INS and GPS errors. Wavelet de-noising is one of th...     

Dynamic Bayesian networks and variable length genetic algorithm for designing cue-based model for dialogue act recognition

The automatic recognition of dialogue act is a task of crucial importance for the processing of natural language dialogue at discourse level. It is also one of the most challenging problems as most often the dialogue act is not expressed directly in speaker’s utterance. In this paper, a new cue-based model for dialogue act recognition is presented. The model is, essentially, a dynamic Bayesian network induced from manually annotated dialogue corpus via dynamic Bayesian machine learning algorithms. Furthermore, the dynamic Bayesian network’s random variables are constituted from sets of lexical cues selected automatically by means of a variable length genetic algorithm, developed specifically for this purpose. To evaluate the proposed approaches of design, three stages of experiments have been conducted. In the initial stage, the dynamic Bayesian network model is constructed using sets of lexical cues selected manually from the dialogue corpus. The model is evaluated against two previously proposed models and the results confirm the potentiality of dynamic Bayesian networks for dialogue act recognition. In the second stage, the developed variable length genetic algorithm is used to select different sets of lexical cues to constitute the dynamic Bayesian networks’ random variables. The developed approach is evaluated against some of the previously used ranking approaches and the results provide experimental evidences on its ability to avoid the drawbacks of the ranking approaches. In the third stage, the dynamic Bayesian networks model is constructed using random variables constituted from the sets of lexical cues generated in the second stage and the results confirm the effectiveness of the proposed approaches for designing dialogue act recognition model.     

Distance functions and skeletal representations of rigid and non-rigid planar shapes

Shape skeletons are fundamental concepts for describing the shape of geometric objects, and have found a variety of applications in a number of areas where geometry plays an important role. Two types of skeletons commonly used in geometric computations are the straight skeleton of a (linear) polygon, and the medial axis of a bounded set of points in the k-dimensional Euclidean space. However, exact computation of these skeletons of even fairly simple planar shapes remains an open problem.In this paper we propose a novel approach to construct exact or approximate (continuous) distance functions and the associated skeletal representations (a skeleton and the corresponding radius function) for solid 2D semi-analytic sets that can be either rigid or undergoing topological deformations. Our approach relies on computing constructive representations of shapes with R-functions that operate on real-valued halfspaces as logic operations. We use our approximate distance functions to define a new type of skeleton, i.e, the C-skeleton, which is piecewise linear for polygonal domains, generalizes naturally to planar and spatial domains with curved boundaries, and has attractive properties. We also show that the exact distance functions allow us to compute the medial axis of any closed, bounded and regular planar domain. Importantly, our approach can generate the medial axis, the straight skeleton, and the C-skeleton of possibly deformable shapes within the same formulation, extends naturally to 3D, and can be used in a variety of applications such as skeleton-based shape editing and adaptive motion planning.     

A new dual wing harmonium model for document retrieval

A new dual wing harmonium model that integrates term frequency features and term connection features into a low dimensional semantic space without increase of computation load is proposed for the application of document retrieval. Terms and vectorized graph connectionists are extracted from the graph representation of document by employing weighted feature extraction method. We then develop a new dual wing harmonium model projecting these multiple features into low dimensional latent topics with different probability distributions assumption. Contrastive divergence algorithm is used for efficient learning and inference. We perform extensive experimental verification, and the comparative results suggest that the proposed method is accurate and computationally efficient for document retrieval.     

A new document representation using term frequency and vectorized graph connectionists with application to document retrieval

This paper presents a new document representation with vectorized multiple features including term frequency and term-connection-frequency. A document is represented by undirected and directed graph, respectively. Then terms and vectorized graph connectionists are extracted from the graphs by employing several feature extraction methods. This hybrid document feature representation more accurately reflects the underlying semantics that are difficult to achieve from the currently used term histograms, and it facilitates the matching of complex graph. In application level, we develop a document retrieval system based on self-organizing map (SOM) to speed up the retrieval process. We perform extensive experimental verification, and the results suggest that the proposed method is computationally efficient and accurate for document retrieval.