Cluster Analysis of Biomedical Image Time-Series

In this paper, we present neural network clustering by deterministic annealing as a powerful strategy for self-organized segmentation of biomedical image time-series data identifying groups of pixels sharing common properties of local signal dynamics. After introducing the theoretical concept of minimal free energy vector quantization and related clustering techniques, we discuss its potential to serve as a multi-purpose computer vision strategy to image time-series analysis and visualization for many fields of medicine ranging from biomedical basic research to clinical assessment of patient data. In particular, we present applications to (i) functional MRI data analysis for human brain mapping, (ii) dynamic contrast-enhanced perfusion MRI for the diagnosis of cerebrovascular disease, and (iii) magnetic resonance mammography for the analysis of suspicious lesions in patients with breast cancer. This wide scope of completely different medical applications illustrates the flexibility and conceptual power of neural network vector quantization in this context. Although there are obvious methodological similarities, each application requires specific careful consideration w.r.t. data preprocessing, postprocessing and interpretation. This challenge can only be managed by close interdisciplinary cooperation of medical doctors, engineers, and computer scientists. Hence, this field of research can serve as an example for lively cross-fertilization between computer vision and related research.     

解决嵌入式网络多接口问题——MCU肩负桥接核心重任

近来,许多嵌入式应用都涉及到嵌入式网络问题,应用中使用了多个微控制器,它们之间相互通信.这样做是因为系统的控制是分布式的,或者是因为远程传感器和执行器需要连接到主控制单元.     

Early Prediction of Therapy Response to Abiraterone Acetate Using PSA Subforms in Patients with Castration Resistant Prostate Cancer

The purpose of this study was to evaluate the prognostic ability of early changes of total prostate specific antigen (tPSA), free PSA (fPSA), [−2]proPSA and the Prostate Health Index (PHI) following initiation of Abiraterone-therapy in men with castration resistant prostate cancer (mCRPC). In 25 patients, PSA-subforms were analyzed before and at 8–12 weeks under therapy as prognosticators of progression-free-survival (PFS) and overall survival (OS). Comparing patients with a PFS < vs. ≥12 months by using Mann–Whitney–Wilcoxon Tests, the relative-median-change of tPSA (−0.1% vs. −86.8%; p = 0.02), fPSA (12.1% vs. −55.3%; p = 0.03) and [−2]proPSA (8.1% vs. −59.3%; p = 0.05) differed significantly. For men with ≤ vs. >15 months of OS there was a non-significant trend for a difference in the relative-median-change of fPSA (17.0% vs. −46.3%; p = 0.06). In Kaplan–Meier analyses, declining fPSA and [−2]proPSA were associated with a longer median PFS (13 months, 95% confidence interval (CI): 9.6–16.4 vs. 10 months, 95% CI: 3.5–16.5; p = 0.11), respectively. Correspondingly, decreasing fPSA and [−2]proPSA values indicated an OS of 32 months (95% CI: not reached (NR)) compared to 21 months in men with rising values (95% CI: 7.7–34.3; p = 0.14), respectively. We concluded that the addition of fPSA- and [−2]proPSA-changes to tPSA-information might be further studied as potential markers of early Abiraterone response in mCRPC patients.     

Unannounced Evacuation Experiment in a High-Rise Hotel Building with Evacuation Elevators: A Study of Evacuation Behaviour Using Eye-Tracking

Past studies suggest that people are often reluctant to use occupant evacuation elevators in case of fire. However, existing research is scarce and current knowledge is based on questionnaire studies and laboratory experiments. An unannounced evacuation experiment was therefore performed on the 16th floor of a 35-floor high-rise hotel building. Sixty-seven participants took part and eye-tracking glasses were used to collect data on exit choice and eye fixations. Three different scenarios were studied, including two different hotel room locations on the floor and a variation of guidance system for one of these locations, i.e., flashing green lights next to the evacuation sign at the elevators. Results suggest that people typically choose the elevator for evacuation, even if their hotel room was located closer to the evacuation stair. Flashing green lights next to an evacuation sign made people look more at this sign. However, in spite of looking more at the sign, the flashing light was not shown to significantly improve compliance with the sign. Also, the results suggest that a detector activated self-closing fire door without vision panels to the elevator lobby made it more difficult to find the evacuation elevators in an emergency.

     

Compact cw Terahertz Spectrometer Pumped at 1.5 μm Wavelength

A compact and low-cost continuous wave terahertz spectrometer operating at an optical wavelength of 1.5 μm is presented. The spectrometer employs high power distributed feedback (DFB) laser diodes in integrated “butterfly” packages. No further optical amplification of the beating signal is required. An integrated photodiode antenna with an output power of 5 μW at 500 GHz is used as efficient terahertz emitter. Employing low-temperature grown (LT-) InGaAs/InAlAs photoconductive receivers as coherent detectors, SNR values of the terahertz power up to 75 dB are attained at an integration time of 300 ms. Accurate characterization of the thermal tuning behavior of the DFBs and precise thermal control yield an absolute accuracy of 1 GHz and a resolution of better than 5 MHz, without any on-line monitoring of the optical frequency. Due to the high frequency resolution no delay line is needed to vary the terahertz phase.     

The new Chancellory

This paper originally accompanied the presentation of the project for the new Chancellory.