1,3,5‐Triazino Peptide Derivatives: Synthesis,Characterization, and Preliminary Antileishmanial Activity

A library of short di‐, tri‐, and tetra‐peptides with an s‐triazine moiety at the N terminus and either an amide or ethyl ester C terminus was prepared in solution and on the solid phase. The two remaining positions of the s‐triazine moiety were substituted with methoxy, morpholino, or piperidino groups. All the synthesized peptide derivatives were analyzed by HPLC and fully characterized by IR spectroscopy, ¹H and ¹³C NMR spectroscopy, elemental analysis, and mass spectrometry (MALDI TOF/TOF). A preliminary study of the antileishmanial activity of the 1,3,5‐triazinyl peptide derivatives revealed that four dipeptide amide derivatives showed higher antipromastigote or antiamastigote activity than the reference standard drug miltefosine with no significance acute toxicity.     

Joint reference frame inter-mode selection for fast H.264 video coding

The H.264/AVC video coding standard uses multiple reference frames and variable-size macroblock partitions in inter-prediction. This flexibility allows the standard to achieve excellent rate-distortion performance at the cost of high encoding complexity. We present an algorithm for fast joint selection of the reference frames and macroblock partitions in rate-distortion-based coding. Experimental results for eight standard test video sequences show that, compared with exhaustive search, our algorithm can save up to 74.9 % of the encoding time with negligible loss in rate-distortion performance. The presented algorithm is also evaluated using a subjective assessment metric; quality evaluation measures based on user satisfaction. Diverse types of video sequences were used with different frame rates, quantization parameters, and resolutions. The effects of changing bit rate and resolution on compression efficiency and viewers’ satisfaction are also presented. Results show that our algorithm provides high scores of perceptual satisfaction that are significantly affected by the compression technique. As a result, we claim that our algorithm presents original and significant enhancement compared with exhaustive search. In addition, overall test results showed that our technique outperformed three of the best previously proposed methods and gave higher viewer satisfaction.     

OpenSim: open-source software to create and analyze dynamic simulations of movement

Dynamic simulations of movement allow one to study neuromuscular coordination, analyze athletic performance, and estimate internal loading of the musculoskeletal system. Simulations can also be used to identify the sources of pathological movement and establish a scientific basis for treatment planning. We have developed a freely available, open-source software system (OpenSim) that lets users develop models of musculoskeletal structures and create dynamic simulations of a wide variety of movements. We are using this system to simulate the dynamics of individuals with pathological gait and to explore the biomechanical effects of treatments. OpenSim provides a platform on which the biomechanics community can build a library of simulations that can be exchanged, tested, analyzed, and improved through a multi-institutional collaboration. Developing software that enables a concerted effort from many investigators poses technical and sociological challenges. Meeting those challenges will accelerate the discovery of principles that govern movement control and improve treatments for individuals with movement pathologies.     

Hepatic cholesterol metabolism in experimental nephrotic syndrome

Hypercholesterolemia is a consistent feature of the nephrotic syndrome. However, the mechanisms underlying this perturbation are unclear. In the present work, we have investigated different factors that influence hepatic cholesterol metabolism using the nephrotic rat as a model. The induction of nephrosis resulted in a severe and sustained hypercholesterolemia. However, no effect on the rate-limiting enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl CoA reductase, could be detected. Further, plasma lathosterol/cholesterol ratio, a measure of cholesterol synthesis, was not altered. Also, plasma levels of mevalonate, both a substrate for cholesterogenesis beyond the rate-limiting step and a marker for cholesterol synthesis, did not differ between control rats and those with established hypercholesterolemia. There was no detectable change in the expression of low density lipoprotein (LDL) receptor between the two experimental groups. We conclude that the early increase in cholesterol synthesis reported after the induction of nephrosis is not necessary for the maintenance of hypercholeserolemia. Established hypercholesterolemia of the nephrotic syndrome seems to represent a steady state in which neither enhanced hepatic cholesterol synthesis nor retarded LDL cholesterol clearance is of major importance.     

Hydrophobic polyethersulfone porous membranes for membrane distillation

Membrane distillation (MD) is a thermal, vapor-driven transportation process through micro porous hydrophobic membranes that is increasingly being applied to seawater and brine desalination processes. Two types of hydrophobic microporous polyethersulfone flat sheet membranes, namely, annealed polyethersulfone and a polyethersulfone/tetraethoxysilane (PES/TEOS) blend were prepared by a phase inversion process. The membranes were characterized and their performances were investigated using the vacuum membrane distillation of an aqueous NaCl solution. The performances of the prepared membranes were also compared with two commercially available hydrophobic membranes, polytetrafluorethylene and polyvinylidene fluoride. The influence of operational parameters such as feed temperature (25–65 °C), permeate vacuum pressure (200–800 mbar), feed flow rate (8–22 mL/s) and feed salt concentration (3000 to 35000 mg/L) on the MD permeation flux were investigated for the four membranes. The hydrophobic PES/TEOS membrane had the highest salt rejection (99.7%) and permeate flux (86 kg/m²·h) at 65 °C, with a feed of 7000 ppm and a pressure of 200 mbar.     

Modeling and simulation of solar-powered liquid desiccant regenerator for open absorption cooling cycle

This paper presents the modeling and simulation of solar-powered desiccant regenerator used for open absorption cooling cycles. The input heat, which is the total radiation incident on an inclined surface, is evaluated via a solar radiation model in terms of the location, day of the year, and time of the day. Calcium Chloride (CaCl₂) is applied as the working desiccant in this investigation. The solar radiation model is integrated with the desiccant regenerator model to produce a more realistic simulation. A finite difference method is used to simulate the combined heat and mass transfer processes that occur in the liquid desiccant regenerator. The system of equations is solved using the Matlab-Simulink platform. The effect of the important parameters, namely the regenerator length, desiccant solution flow rate and concentration, and air flow rate, on the performance of the system is investigated. It has been found that the vapor pressure difference has a maximum value for a given regenerator length. It is also shown that for specified operating conditions, a maximum value of the coefficient of performance occurs at a given range of air and solution flow rates. Therefore, it is essential to select the design parameters for each ambient condition to maximize the coefficient of performance of the system.     

Statistical Analysis on the Cost and Duration of Public Building Projects

A probabilistic model is proposed to predict the risk effects on time and cost of public building projects. The research goal is to utilize a real history data in estimating project cost and duration. The model results can be used to adjust floats and budgets of the planning schedule before project commencement. Statistical regression models and sample tests are developed using real data of 113 public projects. The model outputs can be used by project managers in the planning phase to validate the schedule critical path time and project budget. The comparison of means analysis for project cost and time performance indicated that the sample projects tend to finish over budget and almost on schedule. Regression models were developed to model project cost and time. The regression analysis showed that the project budgeted cost and planned project duration provide a good basis for estimating the cost and duration. The regression model results were validated by estimating the prediction error in percent and through conducting out-of-sample tests. In conclusion, the models were validated at a probability of 95%, at which the proposed models predict the project cost and duration at an error margin of ±0.035% of the actual cost and time.     

Effect of mineralogical composition and kerogen content on oil shale natural floatability

Mineralogical composition is one of the important factors that affect the performance of separation processes. In the current study, two oil shale samples, from El-Nakhil and El-Bieda localities, differ in their mineralogical composition, were subjected to flotation tests. Chemical analysis, differential thermal analysis (DTA), thermo-gravimetric analysis (TGA), and microscopic examination are among the used characterization techniques. In addition, their responses for upgrading by flotation were conducted as a function of pH, solid-liquid ratio, stirring speed and different particle sizes. The characterization results indicated that the kerogen content in El-Nakhil sample was 30% while in El-Beida sample was 10%. On the other hand, the flotation results indicated that El-Bieda responses better than that of El-Nakhil in terms of the difference in kerogen % between the original sample and the concentrated ones. The difference in flotation results of two samples can be explained by the difference in kerogen morphology as well as its interaction with surrounding matrix. In El-Bieda the kerogen has a laminated structure but in El-Nakhil it appears as laminated liptinitic component, in addition to the higher carbonate content in El-Nakhil sample in comparison to higher clay content in El-Bieda sample.