Validation of a limited sampling model to determine etoposide area under the curve

STUDY OBJECTIVE: To validate the utility of a previously reported 3-point limited sampling model (LSM) for determining etoposide area under the curve to infinity (AUC(infinity)). DESIGN: Secondary analysis of data from two clinical trials of etoposide. SETTING: University medical center clinical research center. PATIENTS: Thirty-four patients with different malignancies. INTERVENTIONS: Etoposide was administered as a 2-hour infusion to 34 patients. Serial plasma samples were drawn over 24 hours after the infusion and analyzed for etoposide by high-performance liquid chromatography. MEASUREMENTS AND MAIN RESULTS: The 3-point LSM AUC was compared with a 14-point actual AUC calculated by the linear trapezoidal rule. Actual and predicted AUC(infinity) by the LSM were highly correlated (r=0.97, p<0.0001). The LSM predictions had a mean absolute error of 10.9% (95% CI -14.1, -5.3) and a mean error of -9.7% (95% CI 6.9, 14.9). Nine patients with poor AUC(infinity) estimations by the LSM (error > 12%) tended to have abnormally low or high peak concentrations. CONCLUSION: Our findings suggest the development of more robust LSM using other techniques, such as pharmacostatistical models, that can accommodate a greater degree of pharmacokinetic variability.     

石灰石分解反应的热重动力学研究

用热重分析等研究方法，对我国９个主要产地的石灰石矿样品进行了大量的实验和分析工作，并分别计算出不同产地石灰石的动力学数据。     

P偏振光双表面反射比的角谱及其应用

p-偏振光在镀膜平板基片两面的反射光强度比值的角谱是膜层参数(折射率、消光系数和厚度)的函数.实验表明通过角谱的测量和数值模拟是精确测量薄膜参数的新途径.基于此原理,还试制出掺Sb的SnO2溶胶凝胶薄膜的光化学气敏传感器.     

A novel methanol-tolerant Ir-Se chalcogenide electrocatalyst for oyxgen reduction

A novel methanol-tolerant oxygen-reduction catalyst, Iridium-selenium (Ir-Se) chalcogenide, was synthesized by chemical precipitation in an organic solvent. Auger electron spectroscopy (AES) analysis confirmed that the synthesized Ir-Se chalcogenide had a chemical formula of Ir₄Se. This chalcogenide showed strong catalytic activity towards the oxygen reduction reaction (ORR) and a high methanol tolerance. It was found that most of the oxygen could be directly reduced to water through a four-electron pathway with less than 10% hydrogen peroxide (H₂O₂) being produced during the ORR. The improvement in catalytic activity of the Ir-Se chalcogenide in comparison with that of pure Ir might be attributed to the effect of a bimetallic interaction.     

PD275kg／m全长热处理钢轨研制

以高碳低锰碳素热轧钢轨为热处理原料轨，采用双频电感应加热、压缩空气欠速淬火热处理技术研制的ＰＤ２７５ｋｇ／ｍ热处理钢轨，硬化层深度≥１５ｍｍ、组织为细珠光体；力学性能：σ０．２８１５￣９８０ＭＰａ、σｂ１１８５￣１３４０ＭＰａ、δ５１０％￣１５％，常温冲击韧性ａＫ１４￣３３Ｊ／ｃｍ＾２，断裂韧性ＫＩｃ平均值４５．５ＭＰａ·ｍ＾１／２。具有强度高，塑韧性好的综合性能。使用性能优良，寿命比同曲线的Ｕ７     

Performance analysis of the forgetting factor RLS algorithm

An analysis is given of the performance of the standard forgetting factor recursive least squares (RLS) algorithm when used for tracking time-varying linear regression models. Three basic results are obtained: (1) the ‘P-matrix’ in the algorithm remains bounded if and only if the (time-varying) covariance matrix of the regressors is uniformly non-singular; (2) if so, the parameter tracking error covariance matrix is of the order O(μ + γ²/μ), where μ = 1 - λ, λ is the forgetting factor and γ is a quantity reflecting the speed of the parameter variations; (3) this covariance matrix can be arbitrarily well approximated (for small enough μ) by an expression that is easy to compute.     

基于老年群体的健身器材交互设计研究

当今社会,人口老龄化已经成为全世界共同的社会问题,中国也在逐步迈入老龄化社会行列,然而现代信息社会正向年轻化发展。两者的矛盾不言而喻,这让老年人与现代社会脱节越来越严重。文章以老年人健身器材为研究对象,在了解老年人特点的基础上,分析老年人交互式产品的设计原则,总结老年人健身器材设计现状,并提出老年人健身器材交互设计的方法,希望对解决当今社会老龄化问题有一定的推动作用。     

一种基于几何分布的新支持向量机多分类方法

二叉树支持向量机是多分类问题的一种有效方法,然而分类的效果与二叉树的结构密切相关。获得更好的分类效果和更高的效率,要使得二叉树高度尽量小而两个子类尽量易分。距离通常用来衡量两个类的分离程度,但不能反映类的分布情况。考虑到多分类中类的分布,文中定义新的分离度和相似度来衡量两个类的分离度,并且提出了一中新的基于几何分布二叉树支持向量机多分类算法,该方法使得二叉树高度尽量小而两个子类尽量易分。实验表明该方法具有较高的分类准确率和效率。     

BOSCH伺服控制系统在ZJ19B卷接机组中的应用

介绍BOSCH伺服控制系统成功应用于ZJ19B卷接机组传动系统中,使机器供丝、供纸、刀头、嘴机部分各个电机的运行更加稳定,控制精度显著提高;减少因控制精度不够而引起的非正常停机次数,提高机器的有效作业率,节约原料;同时使烟支的重量、圆周、紧头等各项指标合格率显著提高。