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31.
32.
Lerer Barbara; Warner John; Friedman Eitan; Vincent George; Gamzu Elkan 《Canadian Metallurgical Quarterly》1985,99(4):661
The rat magnocellular basal forebrain (MNBF) is homologous to the human nucleus basalis of Meynert, a structure implicated in the cholinergic hypothesis of cognitive impairment in Alzheimer's disease (AD). In the present study, 18 male Sprague-Dawley rats with kainic acid lesions in the MNBF were compared with 6 unoperated controls, 10 sham-operated controls, and 6 controls injected with kainic acid in the cortical area directly above the MNBF. MNBF lesions depleted choline acetyltransferase in cortex but not in striatum or hippocampus. Cortical dopamine levels were unchanged; serotonin levels were unchanged in hippocampus and parietal cortex but decreased in frontal cortex. Compared with controls, MNBF-lesioned Ss were impaired in 24-hr retention, but not acquisition, of a passive avoidance task with escapable footshock. The groups did not differ in mean number of daily avoidances on a barpress active avoidance task, although learning was slower in MNBF-lesioned Ss. In a serial spatial discrimination reversal test, MNBF-lesioned Ss performed significantly worse than controls. This model may be useful for studying the role of the cholinergic system in memory and possibly for developing treatment strategies to alleviate the cognitive dysfunction of AD. (63 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
33.
Testing for the equivalence of factor covariance and mean structures: The issue of partial measurement invariance. 总被引:1,自引:0,他引:1
Byrne Barbara M.; Shavelson Richard J.; Muthén Bengt 《Canadian Metallurgical Quarterly》1989,105(3):456
Addresses issues related to partial measurement invariance using a tutorial approach based on the {lisrel} confirmatory factor analytic model. Specifically, we demonstrate procedures for (a) using "sensitivity analyses" to establish stable and substantively well-fitting baseline models, (b) determining partially invariant measurement parameters, and (c) testing for the invariance of factor covariance and mean structures, given partial measurement invariance. We also show, explicitly, the transformation of parameters from an all-X to an all-Y model specification, for purposes of testing mean structures. These procedures are illustrated with multidimensional self-concept data from low (n?=?248) and high (n?=?582) academically tracked high school adolescents. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
34.
On July 24, 2010, 21 people died and more than 500 were injured in a stampede at the Loveparade, a music festival, in Duisburg, Germany. Although this tragic incident is but one among many terrible crowd disasters that occur during pilgrimage, sports events, or other mass gatherings, it stands out for it has been well documented: there were a total of seven security cameras monitoring the Loveparade and the chain of events that led to disaster was meticulously reconstructed.In this paper, we present an automatic, video-based analysis of the events in Duisburg. While physical models and simulations of human crowd behavior have been reported before, to the best of our knowledge, automatic vision systems that detect congestions and dangerous crowd turbulences in real world settings were not reported yet. Derived from lessons learned from the video footage of the Loveparade, our system is able to detect motion patterns that characterize crowd behavior in stampedes. Based on our analysis, we propose methods for the detection and early warning of dangerous situations during mass events. Since our approach mainly relies on optical flow computations, it runs in real-time and preserves privacy of the people being monitored. 相似文献
35.
The definite trend towards the use of large-diameter rebars and the introduction of high-strength steels (f
y=500 to 600 MPa) make it necessary to study the effects of longitudinal splitting on the steel-to-concrete bond. The study
of splitting effects requires firstly basic tests to be performed in order to gather experimental information on bond and
confinement stresses acting at the bar-to-concrete interface. For this purpose, three series of tests were recently carried
out at the Politecnico di Milano. The results make it possible to ascertain a few basic properties of the bond after concrete
splitting, and to formulate empirical constitutive laws regarding the stresses and the displacements (bar slip and opening
of the splitting crack). All specimens consisted of a short deformed bar embedded in a concrete block, which had a preformed
splitting crack in the plane passing through the bar axis: twelve specimens (Tests A and C) were fitted up with a round deformed
bar having crescent-shaped lugs (Db=18 mm); seven specimens (Tests B) were fitted up with a specially machined deformed bar having a rectangular cross-section
and straigth, lugs, so that concrete deterioration close to the bar could be investigated at the surface of the specimen,
by means of the moiré technique. The tests were carried out at constant slip rate, up to very large slip values (
); both the ascending and the descending branches of the stress-slip curves were measured, for four different values of the
opening of the splitting crack. The agreement among the results of the three series is generally satisfactory and often very
good: consequently, constitutive laws regarding the four main variables (crack opening and bar slip, shear and confinement
stresses) can be worked out, as will be shown in a companion paper on constitutive relationships and on concrete deterioration
at the bar-to-concrete interface. 相似文献
36.
37.
Simonetta Pazzaglia Barbara Tanno Francesca Antonelli Paola Giardullo Gabriele Babini Prabal Subedi Omid Azimzadeh Zohaib N. Khan Kateryna Oleksenko Fabian Metzger Christine von Toerne Damien Traynor Dinesh Medipally Aidan D. Meade Munira Kadhim Fiona M. Lyng Soile Tapio Anna Saran Mariateresa Mancuso 《International journal of molecular sciences》2021,22(8)
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health. 相似文献
38.
A new approach is presented for the characterization of particle motion in fluid-solid systems based on dynamic imaging with a gamma scintillation camera. A two-dimensional spouted bed of 200-500 micron diameter anion exchange resin beads was used as a test system. One or several beads were radiolabeled with the 140 keV gamma emitting radionuclide 99m-Tc pertechnetate, and particle velocity, panicle path, the spatial distribution of particle residence times, and local bed density were determined from the measured temporal and spatial distributions of particle activity. While care must be exercised in the interpretation of data when the scale for changes in the spatial distribution of activity approaches the limits of camera resolution, the method is quantitative, non-invasive, and well suited to the study of systems having symmetry in one spatial dimension. 相似文献
39.
This study investigated what sources were relied on to find out about Osama bin Laden's death and whether perceptions of credibility and political party affiliation influenced these media choices. The most striking difference in media reliance for bin Laden news was that whatever sources Tea Partiers relied on and thought credible were those that Democrats did not rely on or see as credible. Despite the clamor about how quickly news flows through social network sites and Twitter, only about 5% of respondents first heard about bin Laden through these sources and a slightly larger percentage spread the news via these tools. Moreover, social network sites and Twitter were the least relied on about the aftermath of bin Laden's death. 相似文献
40.
Barbara Porter 《计算机与网络》2014,(15):77-77
<正>长期以来,Emulex I/O解决方案的价值一直为全球电信公司所公认。如今,Emulex宣布推出计划中的高级功能,使用这些功能,电信公司能够更快速地开发优质网络服务提供给客户。新增功能包括增强了Emulex OneConnect OCe14000系列10Gb和40Gb以太网(10/40GbE)网络以及融合网络适配器(CNA)的数据包处理并提高了可编程性。使用这些新增功能,电信设备制造商(TEM)和电信运营商可以加快网络功能虚拟化(NFV)解决方案的部署。Emulex已经与6WIND建立合作伙伴关系,共同开发了Emulex轮询模式驱动程序(PMD),以增强数据平面开发工具包 相似文献