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81.
82.
Bocca B Caimi S Smichowski P Gómez D Caroli S 《The Science of the total environment》2006,358(1-3):255-264
Vehicular traffic is the main source of platinum group elements (PGEs) in highly populated urban areas like Buenos Aires where a traffic density of 1,500,000 vehicles day(-1) (corresponding to 7,500 vehicles km(-2)) is estimated. Since there is no information on the levels of PGEs in Buenos Aires, a pilot study was undertaken to ascertain the amount of two major PGEs, namely Pt and Rh, in the atmosphere of this city. To this end, 49 samples of PM-10 particulate matter were collected during 7 days in seven representative sampling sites located downtown Buenos Aires and spread over an area of about 30 km(2). The collection of particulate matter was performed on ash-free glass-fiber filters using high volume samplers with PM-10 sampling heads. Filters loaded with the particulate matter were subjected to microwave (MW)-assisted acid digestion using a combination of HNO(3), HF and HClO(4). The resulting solutions were evaporated and then diluted with 0.1 mol l(-1) HCl. Analyses were performed by sector field inductively coupled plasma-mass spectrometry (SF-ICP-MS) and special attention was paid to the control of mass interferences. Statistical analysis was performed on the experimental data obtained for the element concentrations taking also into account local meteorological data for the monitored period. The highest concentrations of Pt and Rh were detected at two sites (Hospital Alemán and Casa Rapallini) located in streets with traffic consisting mostly of passenger cars. The Pt content (in pg m(-3)) in airborne particulate matter was found to vary from 2.3 to 47.7, with a mean value of 12.9+/-7, and that of Rh from 0.3 to 16.8, with a mean value of 3.9+/-2.8. These concentrations are by far below the levels for which adverse health effects might be expected to occur, i.e., around 100 ng m(-3). On the other hand, monitoring of PGEs should be carried out in a systematic fashion to detect possible dramatic increases from today's levels. 相似文献
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Claudia Riccardi Federica DAria Filomena Anna Digilio Maria Rosaria Carillo Jussara Amato Dominga Fasano Laura De Rosa Simona Paladino Mariarosa Anna Beatrice Melone Daniela Montesarchio Concetta Giancola 《International journal of molecular sciences》2022,23(9)
A set of guanine-rich aptamers able to preferentially recognize full-length huntingtin with an expanded polyglutamine tract has been recently identified, showing high efficacy in modulating the functions of the mutated protein in a variety of cell experiments. We here report a detailed biophysical characterization of the best aptamer in the series, named MS3, proved to adopt a stable, parallel G-quadruplex structure and show high nuclease resistance in serum. Confocal microscopy experiments on HeLa and SH-SY5Y cells, as models of non-neuronal and neuronal cells, respectively, showed a rapid, dose-dependent uptake of fluorescein-labelled MS3, demonstrating its effective internalization, even in the absence of transfecting agents, with no general cytotoxicity. Then, using a well-established Drosophila melanogaster model for Huntington’s disease, which expresses the mutated form of human huntingtin, a significant improvement in the motor neuronal function in flies fed with MS3 was observed, proving the in vivo efficacy of this aptamer. 相似文献
85.
Fani Ziouti Maximilian Rummler Beatrice Steyn Tobias Thiele Anne Seliger Georg N. Duda Bjarne Bogen Bettina M. Willie Franziska Jundt 《International journal of molecular sciences》2021,22(8)
Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton’s tyrosine kinase inhibitor CC-292 (spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microcomputed tomography (microCT) and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD. 相似文献
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A viscous, gel-like phase was found in ultracentrifuged human upper intestinal contents collected during rapid fat lipolysis.
This “gel” phase was layered in the ultracentrifuge tube between the micellar and oil phase. The gel contained lipids typical
of the micellar and not the oil phase. The concentration of these lipids was higher and the ratio of total bile salts to lipids
was lower in the gel than in the micellar phase. The gel, unlike the micellar phase, was birefringent between crossed polarizers.
These data demonstrate that lipids in this gel phase can form liquid crystals in the gut during fat digestion. 相似文献
88.
89.
The continuous cell-to-cell mapping technique (CCCMT) is a recently proposed Markovian approach which can be used for the dynamic reliability and safety analysis of process control systems, as well as for the global analysis of nonlinear dynamic systems in general. A parametric study is performed on the computational efficiency of CCCMT as a function of various integration schemes. The results show that a variable stepsize scheme is desirable with a sufficient required precision. Among the integration schemes considered, a fourth order Runge-Kutta scheme seems to be preferable for short term simulations and the mid-point implicit scheme seems to be preferable for long term simulations or to obtain the steady-state system behavior. 相似文献
90.
Henik Avishai; Nissimov Erez; Priel Beatrice; Umansky Roberto 《Canadian Metallurgical Quarterly》1995,104(4):576
Schizophrenic and control participants received 2 blocks of trials in each experiment. In 1 block they were exposed to regular priming trials (doctor–nurse), and in another block a nonlexical probe was presented at prime onset for 40 ms. Regardless of stimulus onset asynchrony (SOA), the schizophrenic patients showed hyperpriming when no distractor was present. Paying attention to the distracting stimulus reduced priming in the patient group irrespective of SOA. Under certain situations, the reduction in priming appeared even when participants were asked to ignore the distracting stimulus. Thus, even a nonsemantic distractor may be detrimental to schizophrenic patients' language processing. That SOA did not modulate the reduction in priming effect is consistent with the suggestion that attentional resources are required even with short prime–target intervals. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献