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81.
Attila Kertész Mariann Bombicz Daniel Priksz Jozsef Balla Gyorgy Balla Rudolf Gesztelyi Balazs Varga David D. Haines Arpad Tosaki Bela Juhasz 《International journal of molecular sciences》2013,14(9):19086-19108
The present study evaluates a hypothesis that diet-related hypercholesterolemia increases oxidative stress-related burden to cardiovascular tissue, resulting in progressively increased mortality, along with deterioration of electrophysiological and enzymatic function in rabbit myocardium. New Zealand white rabbits were divided into four groups, defined as follows: GROUP I, cholesterol-free rabbit chow for 12 weeks; GROUP II, cholesterol-free chow, 40 weeks; GROUP III, chow supplemented with 2% cholesterol, 12 weeks; GROUP IV, chow supplemented with 2% cholesterol, 40 weeks. At the 12 and 40 weeks time points, animals in each of the aforementioned cohorts were subjected to echocardiographic measurements, followed by sacrifice. Significant deterioration in major outcome variables measured in the present study were observed only in animals maintained for 40 weeks on 2% cholesterol-supplemented chow, with much lesser adverse effects noted in animals fed high cholesterol diets for only 12 weeks. It was observed that rabbits receiving high cholesterol diets for 40 weeks exhibited significantly increased mortality, worsened ejection fraction and general deterioration of cardiac functions, along with increased atherosclerotic plaque formation and infarct size. Additionally, myocardium of GROUP IV animals was observed to contain lower levels of heme oxygenase-1 (HO-1) and cytochrome c oxidase III (COX III) protein relative to the controls. 相似文献
82.
The concept of practical stability is applied to the case of dewetted Bridgman crystal growth on Earth, in a simplified configuration. Taking into account both heat transfer and capillarity, it is formally demonstrated that the process is stable in case of convex menisci, provided that pressure fluctuations remain in a range which can be computed. The theoretical concepts are illustrated by examples involving InSb and GaSb crystal growth. It is concluded that practical stability gives valuable knowledge of the dynamics of the studied technique and could be usefully applied to other crystal-growth processes, especially those involving capillary shaping. 相似文献
83.
P. K. Vinod Paula Freire Ahmed Rattani Andrea Ciliberto Frank Uhlmann Bela Novak 《Journal of the Royal Society Interface》2011,8(61):1128-1141
The operating principles of complex regulatory networks are best understood with the help of mathematical modelling rather than by intuitive reasoning. Hereby, we study the dynamics of the mitotic exit (ME) control system in budding yeast by further developing the Queralt''s model. A comprehensive systems view of the network regulating ME is provided based on classical experiments in the literature. In this picture, Cdc20–APC is a critical node controlling both cyclin (Clb2 and Clb5) and phosphatase (Cdc14) branches of the regulatory network. On the basis of experimental situations ranging from single to quintuple mutants, the kinetic parameters of the network are estimated. Numerical analysis of the model quantifies the dependence of ME control on the proteolytic and non-proteolytic functions of separase. We show that the requirement of the non-proteolytic function of separase for ME depends on cyclin-dependent kinase activity. The model is also used for the systematic analysis of the recently discovered Cdc14 endocycles. The significance of Cdc14 endocycles in eukaryotic cell cycle control is discussed as well. 相似文献
84.
GA Balint 《Canadian Metallurgical Quarterly》1998,19(10):401-403
The exact mechanism of action of the anti-ulcerogenic drugs is still under debate. According to the literature, under normal conditions the cAMP:cGMP ratio in the rat gastric mucosa is approximately 8:10. Following prostacyclin administration, this ratio transiently decreases but later shows a strong elevation, indicating profound changes in the intracellular cyclic nucleotide balance. There is evidence that this elevation or 'shift' in the cAMP:cGMP ratio is linked, on a cellular or molecular level, to the anti-ulcerogenic, cytoprotective processes in the stomach. Cimetidine and ranitidine (widely used H2 receptor-blocking drugs) administered at doses that are too low to interfere with gastric acid secretion, cause an elevation in the cAMP:cGMP ratio, an effect that is also observed with other prostaglandin derivatives and anti-ulcerogenic drugs. In this article, Gabor A. Balint discusses these data and how the elevation of the gastric mucosal cAMP:cGMP ratio is a useful molecular marker that could provide insights into the effects of anti-ulcerogenic drugs. 相似文献
85.
It is shown that the simplified system of differential equations that governs the motion of the automatic-landing flight-experiment (ALFLEX) reentry vehicle is neither structurally stable, nor topologically equivalent to the general dynamical system governing the same motion. Hence, the general and the simplified mathematical models of ALFLEX give different images of the same reality. 相似文献
86.
Paolo Terenziani Bela Stantic Alessio Bottrighi Abdul Sattar 《Journal of Intelligent Information Systems》2013,41(2):151-186
Periodic data play a major role in many application domains, spanning from manufacturing to office automation, from scheduling to data broadcasting. In many of such domains, the huge number of repetitions make the goal of extesionally storing and accessing such data very challenging. In this paper, we propose a new methodology, based on an intensional representation of periodic data. The representation model we propose captures the notion of periodic granularity provided by the temporal database glossary, and is an extension of the TSQL2 temporal relational data model. We define the algebraic operators, and introduce access algorithms to cope with them, proving that they are correct with respect to the traditional extesional approach. We also provide an experimental evaluation of our approach. 相似文献
87.
88.
Bela Gold 《IIE Transactions》1983,15(1):63-78
In Part I, a framework for the analysis and measurement of productivity was provided, along with a sample of some empirical findings obtained with this framework. In this paper, the array of factors which must be examined in order to account for the observed findings is reviewed. Problems encountered in the application of this framework in different kinds of plants are discussed, including problems with the development of managerial ability to interpret the results of the analysis. 相似文献
89.
90.