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11.
VA Fl?renes N Bhattacharya MR Bani Y Ben-David RS Kerbel JM Slingerland 《Canadian Metallurgical Quarterly》1996,13(11):2447-2457
We have studied TGF-beta mediated G1 arrest in WM35, an early stage human melanoma cell line. These cells have lost p15INK4B expression through loss of one chromosome 9 and rearrangement of the other. In asynchronously growing WM35, TGF-beta caused reductions in cyclin D1, cyclin A and cdk4 proteins and their associated kinase activities and an increase in both p21Cip1/WAF1 and p27Kip1. These findings were confirmed in cells released from quiescence in the presence of TGF-beta, in which TGF-beta inhibited or delayed the reduction in the cdk inhibitors that normally occurs in late G1. In contrast to observations in other cell types, there was an increased association of both p21Cip1/WAF1 and p27Kip1 with cyclin D1/cdk4 and with cyclin E/cdk2 during TGF-beta mediated arrest of asynchronously growing cells. Upregulation of p21Cip1/WAF1 preceded that of p27Kip1. Furthermore, p21Cip1/WAF1 and p27Kip1 were not present in the same cdk complexes but bound distinct populations of target cdk molecules. Both p21Cip1/WAF1 and p27Kip1 immunoprecipitates from asynchronously growing cells contained active kinase complexes. These KIP-associated kinase activities were reduced in TGF-beta arrested cells. It has been proposed that in TGF-beta arrested epithelial cells, up-regulation of p15INK4B and of p15INK4B binding to cdk4 serves to destabilize the association of p27Kip1 with cyclin D1/cdk4, promoting p27Kip1 binding and inhibition of cyclin E/cdk2. Our findings demonstrate that this is not a universal mechanism of G1 arrest by TGF-beta. In TGF-beta arrested WM35, which lack p15INK4B, the increased p21Cip1/WAF1 may serve a similar function to that of p15INK4B: initiating kinase inhibition and providing an additional mechanism to supplement the effect of p27Kip1 on G1 cyclin/cdks. 相似文献
12.
The effect of interface-roughness-related disorder on the electronic and optoelectronic properties of a quantum wire structure are studied. It is seen that the disorder causes strong localization in the quasi-one-dimensional system. While the electronic states are seriously perturbed, the density of states is not affected drastically. Optoelectronic properties as reflected in the interband transition related phenomenon are not found to suffer significant deterioration as a result of the disorder. However, the results suggest that intraband relaxation processes may be seriously affected because of electron (hole) states being localized in different regions of the wire 相似文献
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The problem of dynamic scheduling of customers (messages) in time-critical environments is discussed. A single station (communication node) is considered, and it is assumed that each customer (message) must begin service (transmission) by an individually varying extinction time or else it is lost. Interest is in minimizing, in the sense of stochastic order, the number of messages lost over any time interval. A variety of results is proved that establishes the optimality of the shortest-time-to-extinction policy under rather general conditions. Similar results are found when messages have constraints on their complete transmission times. A network of M stations in tandem is considered under the hypothesis that a message is never lost and is scheduled irrespective of whether its extinction time (also called due date in this case) has expired or not. Under fairly general assumptions on the arrivals, deadlines, and services, it is shown that the earliest-due-date policy minimizes a form of average tardiness incurred over a finite operating horizon among all non-idling nonpreemptive policies. These problems are formulated in the context of stochastic dominance, and simple interchange arguments are used to establish all results 相似文献
15.
Mukherjee K. SenGupta S. Bhattacharya T.K. Chattopadhyay A.K. 《Energy Conversion, IEEE Transaction on》2002,17(2):197-202
This paper presents a simplified analytical model of a silicon-controlled-rectifier based, load-commutated inverter driven, commutatorless series motor to predict its speed-current, torque-current and torque-speed characteristics. The model has been formulated, keeping in view the steady state equivalent circuit of a conventional DC series motor. The proposed analytical expressions relating torque and current with speed are found to follow an inverse law and that relating torque and current is found to be parabolic, as is expected in a "series" machine. The drive has been implemented, loaded with a DC generator and experimentally similar characteristics have been obtained, as predicted by the analytical model. The characteristics obtained experimentally are seen to follow the ones, predicted by the analytical model closely 相似文献
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An experimental investigation under cold condition was made to study the effects of some operating/design parameters and non-mechanical L valve configuration on the solid circulation rate in a 4.5 m tall, 0.15 m diameter circulating fluidized bed with riser flow rate varying from 1400 litres/min to 2000 litres/min and bed inventory from 15 kg to 25 kg of sand of average sizes 200 μm, 400 μm and 500 μm. Solid circulation rate was estimated by measuring velocity of sand particle travelling through a vertical Perspex tube section at the bottom of the return leg. It was found to be in the range of 2.8 to 12.3kg/m2s, 0.07 to 9.1kg/m2s and 0.12 to 2.23kg/m2s for sand sizes of 200 μm, 400 μm and 500 μm, respectively for a horizontal L valve. Two mathematical correlations have been developed from the experimental results to predict solid circulation rate as a function of riser flow rate, aeration flow rate, total bed inventory and particle size used. 相似文献
18.
Anjana Bhattacharya Jagannath Das Swapan Mitra Sisir K. Roy 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1992,54(4):399-407
Silicoaluminophosphate (SAPO-5) molecular sieves have been synthesised from reaction mixtures having a molar composition of: 0.7–1.0 Al2O3:0.7–1.0 P2O5:0.01–2.0 SiO2:xR:40 H2O (where R = (C2H3)3N or (C2H3)4NOH and x = 1.5–2.5 for (C2H5)5N and 0.5 for (C2H5)4NOH, at 473 K using various sources of alumina and silica. The effects of (i) varying the crystallinity of the alumina source (boehmite) and (ii) the use of different silica sources such as freshly prepared silica either from sodium silicate or paddy husk extract, silica gel from commercial water-glass, and tetraethyl orthosilicate have been studied. The crystallinity of boehmite has been found to have a strong effect on its reactivity towards the formation of SAPO-5. The activity of boehmite for SAPO-5 formation increased with a decrease in its crystallinity (or with increase in its moisture content). Any silica source devoid of sodium ions could be employed for the synthesis of SAPO-5. The process of crystallisation started as early as within 1.5 h of reaction and incorporation of silicon into the AlPO4 framework has been noted at this stage. Formation of some tridymite phase as impurity has been observed under conditions such as (i) SiO2 concentration > 1.7 mole and (ii) x > 2.0 when R = (C2H5)3N. 相似文献
19.
An 8-valued commutative ring is developed to process colored images. Algebraic operators are defined to perform a number of operations such as the extraction of the primary colors and contours of different colors. 相似文献
20.
The devolatilization and volatile combustion of a single coal particle in spouted and spout-fluid beds have been studied. The results showed that the flame extinction time increases with the particle diameter, and decreases with the bed temperature. When the bed temperature and the air flow rate were fixed, the operation modes (spouted or spout-fluid bed) showed less effect on the mean flame extinction time. A mathematical model of the spouted bed mode for preignition and postignition periods has also been developed assuming the devolatilization rate to be controlled by heat transfer and multireaction pyrolysis kinetics based on volatile products. Ignition, heat transfer back from the volatile flame to the particle surface, variation in flame temperature, and the hydrodynamics of SB are taken into account. The model predictions, with some adjusting parameters, were in good agreement with experimental results. 相似文献