Red blood cell glutathione status in patients with gastrointestinal malignancies treated with 5-fluorouracil

As an alternative to surgical splenectomy, partial splenic embolization was performed in seven children for hypersplenism manifested by splenomegaly, thrombocytopenia, leukopenia, and erythrocyte hemolysis. Within a few days, platelet and leukocyte counts rose significantly in all patients and were maintained in six of seven patients during a follow-up period of 9 to 69 months. Spleen size and abdominal distention also decreased significantly in all children. There were no infectious complications.     

Multifocal primary neuroblastoma

The purpose of this study is to present three patients with multifocal primary neuroblastoma, to review the literature, and describe the radiographic findings. SUBJECTS AND METHODS: Three children with multifocal neuroblastoma have been identified. The case histories and imaging findings in these patients are reviewed. RESULTS: Two children had synchronous and one child had metachronous multifocal primary neuroblastoma. The primary tumors were both in the abdomen in one patient, both in the chest in another patient, and in the chest and abdomen in the third patient. Evidence for multifocal origin of these tumors, rather than metastatic spread, is presented. CONCLUSION: Multifocal primary neuroblastomas can occur. The tumors maybe synchronous or metachronous. Awareness of this disorder may prevent errors in diagnosis and staging. Although not identified in our patients there is a strong familial incidence of neuroblastomas in those patients with multifocal tumors.     

Outcome of cardiac valve ring abscesses after medical treatment: attempt to identify criteria of favorable prognosis

OBJECTIVES: Identify factors predicting favorable outcome after medical management of valve ring abscesses in order to propose a surveillance schedule for conservative treatment. METHODS: A multicentric study conducted from July 1989 to February 1996 included 28 patients (mean age 64 +/- 16 years, range 26-83) hospitalized for active endocarditis and valve ring abscesses diagnosed at transthoracic or transesophageal echography. Conservative medical therapy was given because of a decision of the medico-surgical team (n = 9), high surgical risk (n = 12), or patient refusal of surgery (n = 7). Outcome was favourable in 18 patients (Group I) and unfavorable in 10 (Group II) due to death (n = 9) or subsequent surgery (n = 1). Univariate and multivariate analysis were used to determine differences between the groups in terms of clinical and laboratory data. RESULTS: Mean follow-up in Group I was 33 +/- 18 months and 15 +/- 10 months in Group II. Univariate analysis showed significant differences between Group I and II respectively for age (59 +/- 18 yr vs 72 +/- 10, p = 0.04), delay to apyrexia after antibiotics (4.3 +/- 2.8 vs 8.3 +/- 2.4 days, p < 0.0008), heart failure (5% vs 70%, p = 0.003), grade III or IV valvular regurgitation (5% vs 60%, p < 0.04), and mean surface area of the abscess (1.5 +/- 1.2 vs 5.4 +/- 6.4 cm2, p < 0.03). Independent factors at multivariate analysis were by decreasing order: lack of heart failure at admission, delay to apyrexia, abscess surface area, and age. Outcome was favorable (mean follow-up 33 +/- 10 months) in all patients with an abscess surface area < 1.5 cm2, no signs of heart failure, no grade III or IV valvular regurgitation, apyrexia after less than 8 days on antibiotics and no staphylococcus positive blood culture. CONCLUSION: Medical management of valve ring abscesses may be indicated in selected patients in care units with rigorous surveillance facilities. Further studies are needed to precisely identify surveillance and treatment criteria.     

In vitro activities of semisynthetic pneumocandin L-733,560 against fluconazole-resistant and -susceptible Candida albicans isolates

Lipopeptide L-733,560 is a water-soluble derivative of pneumocandin B0 that exhibits enhanced anti-Candida activity. We investigated the in vitro activity of L-733,560 compared with those of amphotericin B, flucytosine, and itraconazole, against fluconazole-resistant (n = 44) and fluconazole-susceptible (n = 46) Candida albicans isolates. Tests were performed with a photometer-read broth microdilution method with RPMI-2% glucose and National Committee for Clinical Laboratory Standards reference strains. Except for those of itraconazole, MICs were not significantly different between the two groups of isolates, as expected for agents with different mechanisms of action. L-733,560 was the most active agent against C.albicans, with MICs for 50 and 90% of the strains tested of 0.01 and 0.06 microgram/ml, respectively.     

液态混合有机标准物质研究

本研究采用重量法配制有机液态混合标样 ,并对配制方法、混合标样的均匀性、稳定性及影响不确定度的因素进行了研究 ,并用气相色谱法进行了比对分析。经稳定性监测 ,稳定度大于等于一年 ,不确定度小于± 2 %。     

竖直狭缝通道中液氮沸腾强化换热的实验研究

实验表明，狭缝间隙对液氮自然对流核态沸腾换热有明显的影响，在低热流密度下，间隙小的狭缝沸腾换热比间隙大的狭缝明显增强，当狭缝间隙小于实验压力下气泡的脱离直径时，对于同样的热流密度，传热温差减小一个数量级以上，沸腾换热系数提高十几倍到二十倍以上，当热流密度增加一定程度（＞4W/cm^2)时，间隙小的狭缝沸腾换热比间隙大的狭缝有所减弱。     

统筹规划做好农民饮水安全工作

北京市在落实全国水利发展“十一五”规划中提出按照统筹城乡、统筹农村供排水、发展集约化供水模式的思路解决农村供水问题，坚持水资源的节流、开源与保护并重。2004年下半年开始．北京市水务局组织各区县水务部门进行翔实的农村水务调查，在各级政府的高度重视和配合下，     

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可燃气体在运输、储存、加工和使用过程中，因可燃气体泄漏而形成的气云爆炸事故，常常会造成巨大的人员伤亡和财产损失。研究气云爆炸的特性和威力，可防范事故，减小损失。中采用有限差分方法编制了求解可燃气云爆炸过程的定解方程的数值模拟程序。方程组中的源项由能量均匀加入法处理，爆炸场中的间断问题通过人工黏性模型处理。经开敞空间乙炔——空气气云爆炸实验结果检验，数值计算结果的偏差在13％以内。计算结果表明，气云半径越大，爆炸最大压力和压力增加速率越大；气云爆热越大，爆炸最大压力和压力增加速率越大。     

基于加载算法的室内无线信道OFDM接收机的性能

本文研究了无线局域网中使信号频谱得到优化的一种简单OFDM子载波加载算法。此算法基于边缘自适应（Margin Adaptive）加载准则及其在室内无线信道上的性能。