MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics

Adipocytic tumors are the most common subtype of soft tissue tumors. In current clinical practice, distinguishing benign lipomas from well-differentiated liposarcomas (WDLPS), as well as dedifferentiated liposarcomas (DDLPS) from their morphologic mimics, remains a significant diagnostic challenge. This is especially so when examining small biopsy samples and without the aid of additional ancillary tests. Recognizing the important role that microRNAs (miRNAs) play in tumorigenesis and their potential utility in tumor classification, we analyzed routine clinical tissue samples of benign and malignant lipomatous tumors, as well as other sarcoma mimics, to identify distinguishing miRNA-based signatures that can aid in the differential diagnosis of these entities. We discovered a 6-miRNA signature that separated lipomas from WDLPS with high confidence (AUC of 0.963), as well as a separate 6-miRNA signature that distinguished DDLPS from their more aggressive histologic mimics (AUC of 0.740). Functional enrichment analysis unveiled possible mechanistic involvement of these predictive miRNAs in adipocytic cancer-related biological processes and pathways such as PI3K/AKT/mTOR and MAPK signaling, further supporting the relevance of these miRNAs as biomarkers for adipocytic tumors. Our results demonstrate that miRNA expression profiling may potentially be used as an adjunctive tool for the diagnosis of benign and malignant adipocytic tumors. Further validation studies are warranted.     

脉冲光源原子吸收光谱仪信号数字处理软件的设计

通过实验室设计的脉冲光源钨丝原子吸收光谱仪,采集到一个分析信号和光源载波叠加的复合信号。为了从中提取原子吸收分析信号,首先对该复合信号进行数值微分,确定光源脉冲载波每个峰的坐标和相应的峰高,算出每个载波峰位相应的吸光度值,绘制吸收峰轮廓图;然后根据辛普森(Simpson)数值积分原理,求出吸收峰的面积,从而得到积分吸光度值。在微软公司的Visual Basic 6．0开发平台上,编写了实现上述功能的软件,以图形和数值的方式,同时输出每次测定结果。该软件系统和钨丝原子吸收光谱仪硬件系统相配合,对铜标准溶液的测试结果为:检出限为0．0133μg/ml,线性范围为0．10- 4．0μg／ml,对1．0μg／ml Cu(n=10)测定的精密度为RSD=4．05％。     

CDMA移动通信中多址用户干扰抵消技术

本文简要讨论了码分多址移动通信中多址用户干扰的产生和抵消机理,并分别介绍了前向链路和反向链路的多址用户干扰抵消技术。     

简易式多功能膛口装置结构及其性能指标的计算法

该文介绍一种被命名为内插管扩张型多功能膛口装置.其结构比较简单,且具有消焰、消声、制退和有利于提高射击精度多种功能.本装置各项性能指标的计算法,是采用实验与理论分析相结合建立的经验公式,既可用作正面计算,也可用作多目标函数综合优化设计的反面计算.     

The Main Progress of Perovskite Solar Cells in 2020–2021

Perovskite solar cells (PSCs) emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from ...     

Owl Shaped You

The Shang Dynasty(16th Century B.C.-11th Century B.C.)Height:20.5 cmBronzePreserved in Shanghai MuseumYou is a vessel to contain wine.This You is in the zoomorphic shape of two owls standing back to back.The cover is shaped as     

浅析《新功能主义及其后》的后实证主义研究方法

从社会学方法论的角度分析亚历山大在<新功能主义及其后>中所运用的后实证主义研究方法.在<新功能主义及其后>中,亚历山大力图重新建构帕森斯的结构功能主义理论传统并建立新的理论综合--新功能主义,为社会学界带来了一种新的理论发展趋势在批判实证主义和反实证主义认识论的基础上,主张在后实证主义认识论的基础上重建多维度的理论框架.