Displacement bound of beam‐column with time‐dependent boundary constraints

Abstract

A simplified explicit formula for the displacement bounds of the beam‐column subjected to time‐dependent boundary constraints is proposed. The formula is derived by means of removing time dependence from the boundary conditions. The proposed bounds provide a quick estimation of the displacements for problems with complex loading conditions.     

影响掺矿渣的钢纤维砼强度的主要因素

研究结果表明 :水胶比、胶凝材料用量、钢纤维掺量、矿渣代水泥量对钢纤维砼强度影响显著。当矿渣取代水泥 10 %时 ,钢纤维砼强度最高。经试验选择出一个具有良好和易性和较高强度 (118MPa)的钢纤维砼配合比 ,为掺磨细矿渣的中含量超短异形钢纤维砼的设计和施工提供了试验依据     

Systemic Delivery of a STING Agonist-Loaded Positively Charged Liposome Selectively Targets Tumor Immune Microenvironment and Suppresses Tumor Angiogenesis

Although stimulator of interferon genes (STING) agonists has shown great promise in preclinical studies, the clinical development of STING agonist therapy is challenged by its limited systemic delivery. Here, positively charged fusogenic liposomes loaded with a STING agonist (PoSTING) are designed for systemic delivery and to preferentially target the tumor microenvironment. When PoSTING is administered intravenously, it selectively targets not only tumor cells but also immune and tumor endothelial cells (ECs). In particular, delivery of STING agonists to tumor ECs normalizes abnormal tumor vasculatures, induces intratumoral STING activation, and elicits robust anti-tumor T cell immunity within the tumor microenvironment. Therefore, PoSTING can be used as a systemic delivery platform to overcome the limitations of using STING agonists in clinical trials.     

Tailored Heterojunction Active Sites for Oxygen Electrocatalyst Promotion in Zinc-Air Batteries

Rechargeable zinc-air batteries (ZABs) are promising energy storage systems due to their low-cost and safety. However, the working principle of ZABs is based on oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), which display sluggish kinetic and low stability. Herein, this work proposes a novel method to design a heterogeneous CoP/CoO electrocatalyst on mesopore nanobox carbon/carbon nanotube (CoP/CoO@MNC-CNT) that enriched active sites and synergistic effect. Moreover, the well-defined heterointerfaces could lower the energy barrier for intermediate species adsorption and promote OER and ORR electrochemical performances. The CoP/CoO@MNC-CNT electrocatalyst presents a high half-wave potential of 0.838 V for ORR and a small overpotential of 270 mV for OER. The ZABs-based CoP/CoO@MNC-CNT air-cathode shows an open-circuit voltage of 1.409 V, the long-term cycle life of 500 h with a small voltage difference change of 7.7%. Additionally, the flexible ZABs exhibit highly mechanical stability, demonstrating their application potential in wearable electronic devices.     

Network morphospace

The structure of complex networks has attracted much attention in recent years. It has been noted that many real-world examples of networked systems share a set of common architectural features. This raises important questions about their origin, for example whether such network attributes reflect common design principles or constraints imposed by selectional forces that have shaped the evolution of network topology. Is it possible to place the many patterns and forms of complex networks into a common space that reveals their relations, and what are the main rules and driving forces that determine which positions in such a space are occupied by systems that have actually evolved? We suggest that these questions can be addressed by combining concepts from two currently relatively unconnected fields. One is theoretical morphology, which has conceptualized the relations between morphological traits defined by mathematical models of biological form. The second is network science, which provides numerous quantitative tools to measure and classify different patterns of local and global network architecture across disparate types of systems. Here, we explore a new theoretical concept that lies at the intersection between both fields, the ‘network morphospace’. Defined by axes that represent specific network traits, each point within such a space represents a location occupied by networks that share a set of common ‘morphological’ characteristics related to aspects of their connectivity. Mapping a network morphospace reveals the extent to which the space is filled by existing networks, thus allowing a distinction between actual and impossible designs and highlighting the generative potential of rules and constraints that pervade the evolution of complex systems.     

Paper-based microfluidic surface acoustic wave sample delivery and ionization source for rapid and sensitive ambient mass spectrometry

A surface acoustic wave-based sample delivery and ionization method that requires minimal to no sample pretreatment and that can operate under ambient conditions is described. This miniaturized technology enables real-time, rapid, and high-throughput analysis of trace compounds in complex mixtures, especially high ionic strength and viscous samples that can be challenging for conventional ionization techniques such as electrospray ionization. This technique takes advantage of high order surface acoustic wave (SAW) vibrations that both manipulate small volumes of liquid mixtures containing trace analyte compounds and seamlessly transfers analytes from the liquid sample into gas phase ions for mass spectrometry (MS) analysis. Drugs in human whole blood and plasma and heavy metals in tap water have been successfully detected at nanomolar concentrations by coupling a SAW atomization and ionization device with an inexpensive, paper-based sample delivery system and mass spectrometer. The miniaturized SAW ionization unit requires only a modest operating power of 3 to 4 W and, therefore, provides a viable and efficient ionization platform for the real-time analysis of a wide range of compounds.     

Recalcitrant tumor of the fifth metacarpal bone in a hemodialyzed patient

The article presents a case report about a 38‐year‐old hemodialyzed woman who presented to our department with a painful, expansile, lytic bone lesion of the fifth metacarpal epiphysis. The lesion was resected and replaced by corticocancellous bone graft. At 3 months, imaging suggested signs of graft resorption and local recurrence which necessitated repeat excision and grafting. Because of secondary parathyroidism subsequent subtotal parathyroidectomy was performed. This procedure leads to appropriate bone remodeling by 8 weeks postoperatively, and recurrence has not been observed at 2 years of follow up.