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991.
JO Park HC Chung JY Cho SY Rha NC You JH Kim SH Noh CB Kim JS Min BS Kim JK Roh 《Canadian Metallurgical Quarterly》1997,20(5):484-489
About one-third of patients with gastric cancer are unresectable at the time of diagnosis. Their median survival is < 6 months, with a grave prognosis. The purpose of this study was to assess the efficacy of a modified FAM (mFAM) regimen in advanced gastric cancer. We retrospectively reviewed the clinical records of 409 advanced gastric cancer patients who had not received curative surgery. Among 409 patients, 202 patients were treated with an mFAM regimen (infusional 5-FU + doxorubocin + mitomycin-C), and 207 patients received no chemotherapy (control group). No differences were found in clinical parameters between the two groups. The 1-year survival rates were 34.1% for the mFAM-treated group and 22.5% for the control group (p = 0.0135). In subset analysis, a higher 1-year survival rate was demonstrated in patients with mFAM and palliative surgery. Of the 154 evaluable patients in the mFAM-treated group, the response rate was 17.5%. In these patients, median response duration was 30 weeks, and progression-free survival was 23 weeks. Overall toxicity of mFAM regimen was relatively tolerable and reversible. In conclusion, FAM combination chemotherapy, which has been used as a standard therapy, prolonged survival after modification of the administration schedule and combination with palliative surgery. A prospective randomized study is warranted to confirm this conclusion from our retrospective study. 相似文献
992.
Numerical accuracy of multipole expansion for 2D MLFMA 总被引:2,自引:0,他引:2
A numerical study of the multipole expansion for the multilevel fast multipole algorithm (MLFMA) is presented. In the numerical implementation of MLFMA, the error comes from three sources: the truncation of the addition theorem; the approximation of the integration; the aggregation and disaggregation process. These errors are due to the factorization of the Green's function which is the mathematical core of the algorithm. Among the three error sources, we focus on the truncation error and a new approach of selecting truncation numbers for the addition theorem is proposed. Using this approach, the error prediction and control can be improved for the small buffer sizes and high accuracy requirements. 相似文献
993.
For the Freundlich equation, the linear dependences of In k and n on T and In k on n were derived theoretically and examined by experimental data. In addition, the influence of the adsorbed amount on the isosteric heat of adsorption was also studied. The result shows that the isosteric heat of adsorption is varied linearly with the logarithm of adsorbed amount, ft is also found from experimental data that the plots of In k vs. n for various adsorbates adsorbed on the same adsorbent can be correlated by a straight line for adsorbates with the similar values of the parameter A' of Clapeyron equation. 相似文献
994.
995.
Over-erase phenomenon in SONOS-type flash memory and its minimization using a hafnium oxide charge storage Layer 总被引:1,自引:0,他引:1
Yan-Ny Tan Chim W.-K. Byung Jin Cho Wee-Kiong Choi 《Electron Devices, IEEE Transactions on》2004,51(7):1143-1147
The over-erase phenomenon in the polysilicon-oxide-silicon nitride-oxide-silicon (SONOS) memory structure is minimized by using hafnium oxide or hafnium aluminum oxide to replace silicon nitride as the charge storage layer (the resulting structures are termed SOHOS devices, where the "H" denotes the high dielectric constant material instead of silicon nitride). Unlike SONOS devices, SOHOS structures show a reduced over-erase phenomenon and self-limiting charge storage behavior under both erase and program operations. These are attributed to the differences in band offset and the crystallinity of the charge storage layer. 相似文献
996.
Expansins are a family of proteins that catalyze long-term extension of isolated cell walls. Previously, two expansin proteins have been isolated from internodes of deepwater rice, and three rice expansin genes, Os-EXP1, Os-EXP2, and Os-EXP3, have been identified. We report here on the identification of a fourth rice expansin gene, Os-EXP4, and on the expression pattern of the rice expansin gene family in deepwater rice. Rice expansin genes show organ-specific differential expression in the coleoptile, root, leaf, and internode. In these organs, there is increased expression of Os-EXP1, Os-EXP3, and Os-EXP4 in developmental regions where elongation occurs. This pattern of gene expression is also correlated with acid-induced in vitro cell wall extensibility. Submergence and treatment with gibberellin, both of which promote rapid internodal elongation, induced accumulation of Os-EXP4 mRNA before the rate of growth started to increase. Our results indicate that the expression of expansin genes in deepwater rice is differentially regulated by developmental, hormonal, and environmental signals and is correlated with cell elongation. 相似文献
997.
Repair of single-base mismatches formed in recombination intermediates in vivo was investigated in Chinese hamster ovary cells. Extrachromosomal recombination was stimulated by double-strand breaks (DSBs) introduced into regions of shared homology in pairs of plasmid substrates heteroallelic at 11 phenotypically silent mutations. Recombination was expected to occur primarily by single-strand annealing, yielding predicted heteroduplex DNA (hDNA) regions with three to nine mismatches. Product spectra were consistent with hDNA only occurring between DSBs. Nicks were predicted on opposite strands flanking hDNA at positions corresponding to original DSB sites. Most products had continuous marker patterns, and observed conversion gradients closely matched predicted gradients for repair initiated at nicks, consistent with an efficient nick-directed, excision-based mismatch repair system. Discontinuous patterns, seen in approximately 10% of products, and deviations from predicted gradients provided evidence for less efficient mismatch-specific repair, including G-A-->G-C specific repair that may reflect processing by a homologue of Escherichia coli MutY. Mismatch repair was > 80% efficient, which is higher than seen previously with covalently closed, artificial hDNA substrates. Products were found in which all mismatches were repaired in a single tract initiated from one or the other nick. We also observed products resulting from two tracts of intermediate length initiated from two nicks. 相似文献
998.
Various membranes, which have different materials and nominal molecular weight cut-offs (MWCO), were compared in terms of rejection of ibuprofen and removal of effluent organic matter (EfOM) from membrane bioreactor (MBR), because pharmaceutical compounds contain a potential risk and EfOM is the precursor of carcinogenic disinfection by-products when reusing for drinking water source. To provide equivalent comparison with respect to hydrodynamic condition, mass transfer parameter, J0/k ratio, was used. A tight-UF membrane with a molecular weight cut off of 8,000 daltons exhibited 25 approximately 95% removal efficiencies of ibuprofen with a molecular weight of 206 with and without presence of EfOM(MBR). EfOM(MBR) caused the reduction of ibuprofen removal efficiency for UF membrane. Rejection of EfOM(MBR) by UF and NF membranes ranged 29 approximately 47% and 69 approximately 86%, respectively. UF membrane could successfully remove ibuprofen at lower J0/k ratio range (< or = 1) in organic free water but could not efficiently reject ibuprofen with a relatively hydrophilic EfOM(MBR) (SUVA < or = 3). 相似文献
999.
Han-il Lee Je-Kwang Cho Kun-Seok Lee In-Chul Hwang Tae-Won Ahn Kyung-Suc Nah Byeong-Ha Park 《Solid-State Circuits, IEEE Journal of》2004,39(7):1164-1169
A fractional-N frequency synthesizer (FNFS) in a 0.5-/spl mu/m SiGe BiCMOS technology is implemented. In order to operate in a wide-band frequency range, a switched-capacitors bank LC tank voltage-controlled oscillator (VCO) and an adaptive frequency calibration (AFC) technique are used. The measured VCO tuning range is as wide as 600 MHz (40%) from 1.15 to 1.75 GHz with a tuning sensitivity from 5.2 to 17.5 MHz/V. A 3-bit fourth-order /spl Sigma/-/spl Delta/ modulator is used to reduce out-of-band phase noise and to meet a frequency resolution of less than 3 Hz as well as agile switching time. The experimental results show -80 dBc/Hz in-band phase noise within the loop bandwidth of 25 kHz and -129 dBc/Hz out-of-band phase noise at 400-kHz offset frequency. The fractional spurious is less than -70 dBc/Hz at 300-kHz offset frequency and the reference spur is -75 dBc/Hz. The lock time is less than 150 /spl mu/s. The proposed synthesizer consumes 19.5 mA from a single 2.8-V supply voltage and meets the requirements of GSM/GPRS/WCDMA applications. 相似文献
1000.
Young Kyu Cho Duk Yong Yoon Byoung-Kee Kim 《Journal of the American Ceramic Society》2004,87(3):443-448
When NbC–30 wt% Co powder compact is sintered at various temperatures where NbC grains (with small amounts of Co) coexist with a liquid Co–NbC matrix, the NbC grains undergo a surface roughening transition with temperature increase and the grain growth changes from abnormal to normal growth. When sintered at 1400°C, the grains are polyhedral with sharp edges (and corners) and grow abnormally because their singular surfaces move by nucleation of surface steps. When sintered at 1600°C, the edges become round, indicating the surface roughening transition. The grains still grow abnormally, but their number density is larger than that at 1400°C because of the smaller surface step free energy. When sintered at 1820°C, the grains are nearly spherical, but the flat-surface segments still remain. The grain growth at this temperature is nearly normal because of very small surface step free energy. The surface roughening transition is reversed when a specimen initially sintered at 1820°C is heat-treated again at 1400°C, but some grains show transition shapes with nearly flat edges and slope discontinuities (shocks). 相似文献