The effect of the putative endogenous imidazoline receptor ligand, clonidine-displacing substance, on insulin secretion from rat and human islets of Langerhans

1. The effects of a rat brain extract containing clonidine-displacing substance (CDS), a putative endogenous imidazoline receptor ligand, on insulin release from rat and human isolated islets of Langerhans were investigated. 2. CDS was able to potentiate the insulin secretory response of rat islets incubated at 6 mM glucose, in a dose-dependent manner. The magnitude of this effect was similar to that in response to the well-characterized imidazoline secretagogue, efaroxan. 3. CDS, like other imidazoline secretagogues, was also able to reverse the inhibitory action of diazoxide on glucose-induced insulin release, in both rat and human islets. 4. These effects of CDS on secretion were reversed by the imidazoline secretagogue antagonists, RX801080 and the newly defined KU14R, providing the first evidence that imidazoline-mediated actions of CDS can be blocked by specific imidazoline antagonists. 5. The effects of CDS on insulin secretion were unaffected when the method of preparation involved centri-filtration through a 3,000 Da cut-off membrane or when the extract was treated with protease. These results confirm that the active principle is of low molecular weight and is not a peptide. 6. Overall, the data suggest that CDS behaves as a potent endogenous insulin secretagogue acting at the islet imidazoline receptor.     

Effects of inconsistencies in eyewitness testimony on mock-juror decision making.

In attempting to impeach an eyewitness, attorneys often highlight inconsistencies in the eyewitness's recall. This study examined the differential impact of types of inconsistent testimony on mock juror decisions. Participants viewed 1 of 4 versions of a videotaped trial in which the primary evidence against the defendant was the testimony of the eyewitness. The types of inconsistent statements given by the eyewitness in the 4 versions were manipulated: (a) consistent testimony, (b) information given on the stand but not during the pretrial investigation, (c) contradictions between on-the-stand and pretrial statements, and (d) contradictions made on the stand. Participants exposed to any form of inconsistent testimony were less likely to convict and found the defendant less culpable and the eyewitness less effective. These effects were larger for contradictions than for information given on the stand but not during pretrial investigations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Contact Fatigue of a Silicon Carbide with a Heterogeneous Grain Structure

A comparative study of cyclic fatigue damage from Hertzian contacts in silicon carbide ceramics with homogeneous microstructure (fine, equiaxed grains, strong grain boundaries) and heterogeneous microstructure (coarse, contiguous elongate grains, weak interphase boundaries) is presented. Observations of the surface and subsurface damage patterns using optical microscopy reveal fundamentally different cyclic fatigue mechanisns: in the homogeneous material, by slow growth of a well-developed cone crack outside the contact area; in the heterogeneous material, by progressive mechanical degradation within a distributed damage zone below the contact area. Scanning electron micrographs of the latter material show copious fine debris in the damage zone, consistent with a degradation mechanism by frictional attrition by forward-reverse sliding at the weak interphase boundaries. Acoustic emission is recorded during both load and unload half-cycles, confirming hysteresis in the sliding process. Flexure tests indicate initially slight strength losses from the cyclic contact damage in both microstructures, followed by accelerated losses at higher numbers of cycles. The underlying basis for establishing an analytical model of damage accumulation in the heterogeneous microstructure in terms of shear-fault sliding, and for designing micro-structures for optimal properties in fatigue and wear applications, is foreshadowed.     

标准单元ASIC／FPGA的权衡与结构化ASIC

看来您已认定,采取购买并组装现成的专用标准产品(ASSP),如嵌入式控制器、外设芯片等,然后再编写您自己的软件这种做法将不能使您设计的产品与您竞争对手的产品有足够大的差别.因此,您会决定选择芯片级设计.两大硅平台竞争对手及其各自的折衷方案已经在各种工业论坛上引起广泛的争论.不过如果您刚涉足这场争论,则很有必要了解下述有关争论的概要.     

Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists

Studies conducted with the goal of discovering a second-generation platelet-activating factor (PAF) antagonist have identified a novel class of potent and orally active antagonists which have high aqueous solubility and long duration of action in animal models. The compounds arose from the combination of the lipophilic indole portion of Abbott's first-generation PAF antagonist ABT-299 (2) with the methylimidazopyridine heterocycle moiety of British Biotechnology's BB-882 (1) and possess the positive attributes of both of these clinical candidates. Structure-activity relationship (SAR) studies indicated that modification of the indole and benzoyl spacer of lead compound 7b gave analogues that were more potent, longer-lived, and bioavailable and resulted in the identification of 1-(N, N-dimethylcarbamoyl)-4-ethynyl-3-[3-fluoro-4-[(1H-2-methylimidazo[4,5-c] pyrid-1-yl)methyl]benzoyl]indole hydrochloride (ABT-491, 22 m.HCl) which has been evaluated extensively and is currently in clinical development.     

Refinement-oriented probability for CSP

Jones and Plotkin give a general construction for forming a probabilistic powerdomain over any directed-complete partial order [Jon90, JoP89]. We apply their technique to the failures/divergences semantic model for Communicating Sequential Processes [Hoa85].The resulting probabilistic model supports a new binary operator, probabilistic choice, and retains all operators of CSP including its two existing forms of choice. An advantage of using the general construction is that it is easy to see which CSP identities remain true in the probabilistic model. A surprising consequence however is that probabilistic choice distributes through all other operators; such algebraic mobility means that the syntactic position of the choice operator gives little information about when the choice actually must occur. That in turn leads to some interesting interaction between probability and nondeterminism.A simple communications protocol is used to illustrate the probabilistic algebra, and several suggestions are made for accommodating and controlling nondeterminism when probability is present.All authors are members of the Programming Research Group; McIver and Seidel are supported by the EPSRC.0     

Soluble IL-6R in plasma cell dyscrasias

The understanding of the biology of multiple myeloma has advanced significantly in the past few years. The identification of the pivotal role of Interleukin-6 (IL-6), the soluble IL-6 receptor (sIL-6R), and how the ligand receptor complex interacts with the signal transducer gp130 has provided new biological insights into plasma cell disorders. Some studies have suggested that sIL-6R levels may have prognostic significance in MM, however this is not a consistent finding. Here the biology and function of IL-6 and sIL-6R are reviewed and the clinical significance of sIL-6R discussed.     

Identifying and predicting adolescent smokers' developmental trajectories.

Very few studies have defined trajectories of smoking. In the present study, we modeled growth in adolescent smoking and empirically identified prototypical trajectories. We conceptualized escalation of smoking as a growth process and modeled rates of change and heterogeneity of these patterns using latent growth mixture modeling. The analysis identified six trajectories with low ambiguity about group membership (early rapid escalators, late rapid escalators, late moderate escalators, late slow escalators-smokers, stable puffers, and late slow escalators-puffers). A trajectory of quitters was not identified. We also examined predictors of the smoking trajectories. The predictors were assessed across the adolescent years and included variables related to smoking and other substance use, as well as a range of variables related to sociodemographic factors and mental health. Observed change in the pattern of predictors across age has implications for the mechanism of effect of these variables in relation to smoking trajectories, including predictors that differentiated among daily smokers, variables that may determine the trajectory (e.g., friends smoking), and variables that may result from the trajectory (e.g., marijuana use, less attachment to friends).     

Permeation and diffusion of environmental pollutants through flexible polymers

Permeation and diffusion characteristics of high density polyethylene (HDPE), elasticized polyolefin, and polychloroprene membranes have been determined for various organic pollutants at 22 and 50°C. A standard ASTM permeation cell method was used to measure the permeation rate while an immersion/weight gain method was used to obtain the diffusion coefficient. Thickness-dependent permeation rates were determined for HDPE membranes. An equimolar mixture of various permeants was also used to see the possibility of synergistic effects by combination of permeants. The experimental results are discussed in relation to the suitability of HDPE membranes in severe environments.     

Male sternal pheromone glands in Acanthosomatid shield bugs from Britain

Pheromone glands are present in the abdominal sternites of the pregenital region in the male adults in all British species of Acanthosomatidae. Secretory units are most numerous in the hawthorn bugAcanthosoma haemorrhoidale and maternal bugElasmucha grisea, next most numerous in the birch bugElasmostethus interstinctus, and least numerous in the juniper bugCyphostethus tristriatus. The largest dorsal abdominal scent glands were found inCyphostetheus. Ordinary dermal glands are also present. They are most numerous along the lateral margins of the abdomen. It is possible that Pendergrast's organ is the source of a female-produced pheromone. Secretory units were numerous in this organ inC. tristriatus female adults.