Radiographic assessment of the cement mantle thickness of the femoral stem in total hip replacement: a case study of 112 consecutive implants

The results are reported of a radiographic study of cement mantle thickness in 112 consecutive primary hip replacements. Measurements were made by three observers of the apparent cement thickness medially and laterally using standard anterior-posterior radiographs. The average cement thickness was 3.2 mm, which is 1.2 mm greater than the size difference between the broach and the prosthesis, and was in the range 2-5 mm in 67 per cent of all measurement points. This has significance for the design of instrumentation to prepare the femoral cavity to give a defined cement mantle thickness. There was a greater cement mantle thickness proximally than distally. In 95 cases it was possible to determine the orientation of the stem within the cement mantle, which showed an even distribution between varus and valgus orientation; 49 per cent were within 1 degree of neutral and only one case was more than 5 degrees from neutral.     

Multifunctional Transmembrane Protein Ligands for Cell‐Specific Targeting of Plasma Membrane‐Derived Vesicles

Liposomes and nanoparticles that bind selectively to cell‐surface receptors can target specific populations of cells. However, chemical conjugation of ligands to these particles is difficult to control, frequently limiting ligand uniformity and complexity. In contrast, the surfaces of living cells are decorated with highly uniform populations of sophisticated transmembrane proteins. Toward harnessing cellular capabilities, here it is demonstrated that plasma membrane vesicles (PMVs) derived from donor cells can display engineered transmembrane protein ligands that precisely target cells on the basis of receptor expression. These multifunctional targeting proteins incorporate (i) a protein ligand, (ii) an intrinsically disordered protein spacer to make the ligand sterically accessible, and (iii) a fluorescent protein domain that enables quantification of the ligand density on the PMV surface. PMVs that display targeting proteins with affinity for the epidermal growth factor receptor (EGFR) bind at increasing concentrations to breast cancer cells that express increasing levels of EGFR. Further, as an example of the generality of this approach, PMVs expressing a single‐domain antibody against green fluorescence protein (eGFP) bind to cells expressing eGFP‐tagged receptors with a selectivity of ≈50:1. The results demonstrate the versatility of PMVs as cell targeting systems, suggesting diverse applications from drug delivery to tissue engineering.     

Characterization of Mo/Au Transition-Edge Sensors with Different Geometric Configurations

Mo/Au transition-edge sensors exhibit weak-link behavior in the measured temperature, \(T\) and field, \(B\) dependence of the critical current \(I_\mathrm{{C}}(T,B)\) . This is a consequence of the longitudinal proximitization between the Nb electrical bias contacts and the bilayer. Understanding how weak-link superconductivity impacts the resistive transition and the detector energy resolution is of great interest. In this contribution we present studies of \(I_\mathrm{{C}}(T,B)\) for three devices that have different geometries of metallic depositions on top of the sensor used for noise mitigation and X-ray absorption. Results show that these features change the measured \(I_\mathrm{{C}}(T,B)\) compared to the previously seen measurements on devices without additional deposition layers. Measurements of the small signal transition parameters \(\alpha \) and \(\beta \) also reveal differences between designs that impact the measured response to X-rays and energy resolution.     

High Count-Rate Studies of Small-Pitch Transition-Edge Sensor X-ray Microcalorimeters

We are developing kilo-pixel arrays of small-pitch transition-edge sensors for high spectral-resolving, high count-rate applications in astrophysics and solar physics measurements. We have fabricated and tested pixels that are \(65\,\upmu \) m in size on a silicon substrate with an X-ray flux of \({\sim }100\) counts per second (cps) per pixel. The X-ray pulses were recorded and analyzed in various ways to obtain high throughput with good energy resolution. We have demonstrated 2.3 eV FWHM resolution with 99.6 % throughput for a 6-keV X-ray flux of 100 cps.     

Kilopixel X-ray Microcalorimeter Arrays for Astrophysics: Device Performance and Uniformity

We are developing kilopixel arrays of TES microcalorimeters to enable high-resolution x-ray imaging spectrometers for future x-ray observatories and laboratory astrophysics experiments. Our current array design was targeted as a prototype for the X-ray Microcalorimeter Spectrometer proposed for the International X-ray Observatory, which calls for a 40×40-pixel core array of 300?μm devices with 2.5?eV energy resolution (at 6?keV). Here we present device characterization of our 32×32 arrays, including x-ray spectral performance of individual pixels within the array. We present our results in light of the understanding that our Mo/Au TESs act as weak superconducting links, causing the TES critical current (I _c ) and transition shape to oscillate with applied magnetic field (B). We show I _c (B) measurements and discuss the uniformity of these measurements across the array, as well as implications regarding the uniformity of device noise and response. In addition, we are working to reduce pixel-to-pixel electrical and thermal crosstalk; we present recent test results from an array that has microstrip wiring and an angle-evaporated copper backside heatsinking layer, which provides copper coverage on the four sidewalls of the silicon wells beneath each pixel.