Determining the optimal maintenance action for a deteriorating repairable system

This paper develops a decision model for risk management of the deterioration of a repairable system. When a failure occurs in a deteriorating system, an optimal maintenance decision that includes the possibility of system replacement, as compared to mere deterioration reduction, should be made. There are many uncertainties associated with deterioration, however, so the decision may require a probabilistic analysis. Here, a well-known nonhomogeneous Poisson process with a power law intensity function is used to model the uncertain behavior of the deteriorating system. A Bayesian statistical approach is adopted to allow for the uncertainty of the parameters of the power law intensity function, which imposes a conjugate prior distribution of the parameters. A power law maintenance cost function and the failure cost are analyzed to determine the magnitude of failure risk reduction by minimizing the expected cost incurred from the maintenance action and future failures. A numerical example is given.     

Enhancement of the Stark effect in coupled quantum wells foroptical switching devices

Significant enhancement of the Stark effect on the electronic state and the optical dipole moments of coupled quantum wells is shown theoretically. The multiband effective mass theory (k&oarr;-p&oarr;), which takes into account coupling between heavy- and light-hole states of the coupled quantum wells is used. Mixing of states in the coupled quantum wells leads to the splitting of subband energy levels. An applied electric field causes repulsion between the split levels as well as the spin-splitting of the valence-subband structure. Comparison with the single quantum well shows that the optical dipole moment is substantially more reduced for the coupled quantum wells at the same electric field because of enhanced charge separation in this structure. A variational method is used to solve the exciton problem in coupled quantum wells. Calculated exciton peak positions versus electric field show very good agreement with recent experiments. Calculated exciton absorption spectra for the ground state show the quenching of the exciton peak at F=30 kV/cm at 5 K. These results may have interesting applications to low-voltage optoelectronic switching devices based on the quantum-confined Stark effect     

Upper bound risk estimates for mixtures of carcinogens

The excess cancer risk that might result from exposure to a mixture of chemical carcinogens usually is estimated with data from experiments conducted on individual chemicals. An upper bound on the total excess risk is estimated commonly by summing individual upper bound risk estimates. The degree to which this approach might overstate the true risk associated with the mixture has not been evaluated previously. This paper reports the results of a Monte Carlo simulation study on the degree of reduction in conservation that might be achieved using alternative methods for calculating mixture upper bounds. An unexpected finding is that for chemicals that exhibit strongly linear dose-response relationships, the summing of multistage-model-based upper bounds on excess risk can be anti-conservative, that is, it can provide less than the nominal 100(1-alpha)% coverage.     

Activated platelet aggregates in thrombotic thromboctyopenic purpura: decrease with plasma infusions and normalization in remission

Circulating activated platelet aggregates (aPA) were assayed by flow cytometry employing mAb alpha-CD62p in eight patients with thrombotic thrombocytopenic purpura (TTP). Elevation of aPA was observed in all patients in active stages of TTP; aPA normalized in remission. Plasma infusions with plasmapheresis decreased aPA in responding patients. The rise and fall of aPA preceded relapses and improvements, respectively. These changes were seen prior to the traditional indicators, LDH, haematocrit, and platelet count. Incubation of plasma from TTP patients with normal whole blood induced formation of aPA; this effect was significantly greater than that of plasmas from ITP patient controls (P < 0.01), suggesting the presence of an aPA-promoting factor in TTP plasma. Parallel experiments using a platelet aggregometer failed to detect effect of TTP plasma on normal blood. In summary, aPA appear to be a marker of disease activity, rising with relapse, falling with plasma therapy, and normalizing in remission. The flow cytometric assay of aPA is more sensitive than aggregometry in detecting the putative aPA-promoting factor in TTP.     

Study of the synthesis of sialon phases from silica–aluminium powder mixture using microwave energy

Using a domestic microwave oven, pellets of a silica–aluminium powder were ignitedand a self-propagating high-temperature synthesis (SHS) reaction occurred to produce Si+AlN+Al2O3 as the resultant phases. Silicon AlN and Al2O3 were subsequently nitrated to synthesize sialon phases under a nitrogen atmosphere without cooling. Thus both the SHS process and the nitration were finished within one-step process, which could save processing time and energy. © 1998 Kluwer Academic Publishers     

Molecular properties of the proteasome activator PA28 family proteins and gamma-interferon regulation

The information processing capabilities of biomolecular excitable media based on nonlinear dynamic mechanisms are discussed. Given even the simplest medium geometry, dynamics and information processing features inherent in biomolecular excitable media proves to be diverse and sophisticated. For the case of pseudo two-dimensional versions these media can be described in terms of neural networks having lateral connections. The main responses of shunting on-center off-surround feedback neural networks and pseudo two-dimensional excitable systems to the external excitations are surprisingly similar. The excitable media are capable of short-time memory, of contour enhancement and quenching or amplifying small features depending on medium state. The analogies discussed reaffirm specific neural net characteristics of excitable media and give the opportunity to estimate more accurate excitable medium characteristics.     

Synchronization of passively mode-locked erbium-doped fiber lasersand its application to optical communication networks

We synchronized two passively mode-locked erbium-doped fiber lasers using a phase lock loop with a large dynamic range and bandwidth, which is realized by using a novel acoustooptic-modulator-grating scheme. Cross-correlation of the two lasers shows the interlaser jitter is under 2 ps (same as the laser pulse width) for period as long as hours. To prove the quality of phase locking, we apply synchronized lasers in two all-optical network applications, one of which requires the lasers to have the same wavelength and the second requires the lasers to be at different wavelengths. In the single wavelength application, the synchronized lasers drive a cascade of two low-birefringence, polarization maintaining, optical logic gates with switching timing window of 4 and 5 ps, respectively. We obtain nonlinear transmission of ~50% at a switching energy of 8 pJ and contrast ratio of 16 dB, which are comparable performance as that obtained using a single laser. In the different wavelength application, we use 0.8 ps pulses to switch 2 ps pulses in a two-wavelength nonlinear optical loop mirror demultiplexer with timing window of 5.5 ps. Stable switching is reached at a efficiency as high as 90% at switching energy of 0.8 pJ, and a contrast ratio of 20 dB. Excellent agreement is found between the experimental data and the simulated results, which exclude the timing jitter