Fourth International Conference on Durability of Building Materials and Components

RILEM Bulletin

Fourth International Conference on Durability of Building Materials and Components     

Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-β Disaggregation

Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought to investigate the structural basis of the Aβ disaggregating activity of biflavonoids and their interactions at the atomic level. A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Aβ fibrils with varying potency due to specific structural differences. The computational analysis herein provides the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferentially bind to the aromatic-rich, partially ordered N-termini of Aβ fibril via the π–π interactions. Moreover, docking scores correlate well with the ThT EC₅₀ values. Molecular dynamic simulations revealed that biflavonoids decrease the content of β-sheet in Aβ fibril in a structure-dependent manner. Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Aβ fibrils. Taken together, our data indicate that biflavonoids promote disaggregation of Aβ fibrils due to their ability to disrupt the fibril structure, suggesting biflavonoids as a lead class of compounds to develop a therapeutic agent for Alzheimer’s disease.     

GICL型鼓形齿联轴器的研制

分析了国内外鼓形齿式联轴器技术的发展和特点，介绍了GICL型鼓形齿式联轴器的研制过程。     

粗糙集理论及其在图像处理中的应用*

首先描述了粗糙集理论的基本概念,包括粗糙集知识表示方法和粗糙集约简理论;叙述了粗糙集理论及其与其他非线性理论相结合在图像处理中的应用情况;最后指出了粗糙集理论应用于图像处理的基本思路,并指出将粗糙集理论与其他非线性理论相结合应用于图像处理,将会产生更加有效的结果.     

Optimal control and energy storage for DC electric train systems using evolutionary algorithms

Railway Engineering Science - Electrified railways are becoming a popular transport medium and these consume a large amount of electrical energy. Environmental concerns demand reduction in energy...     

工业锅炉的无损检测技术

工业锅炉由于承受压力载荷及部分部件直接受火焰和高温烟气加热，因此具有爆炸的危险性。在其制造、安装和使用过程中的无损检测是保证产品质量和安全使用的有效手段之一。论述了上述各阶段采用的无损检测方法及目的。采用的方法除常规的无损检测方法外，还包括X射线实时成像检测和电磁涡流表面裂纹检测等方法。     

模糊控制在半固态浆料制备装置中的应用

介绍了低转速输送管半固态浆料制备装置的原理和组成，采用模糊控制技术改进了该装置的温度控制系统，并详细介绍了该控制系统的总体设计及软硬件方案。试验证明，模糊控制技术的应用提高了该装置的温度控制效果，实现了良好稳定的铝金属半固态浆料微观组织控制作用。     

支持产品协同设计的AD技术与服务层项目人员管理的实现

在产品的协同设计过程中，每个项目都要涉及到众多的工作人员和大量的网络资源。协调好各个人员的工作并且有效、安全地使用网络资源是保证产品设计顺利进行的关键。本文提出并研究了采用活动目录技术来实现协同设计系统的服务层上的项目人员管理需求模式，开发了相应的项目人员管理工具，并且在基于知识的注塑模具和冲压模具设计系统中得到应用。