辽宁省2017-2019年肠道病毒71型灭活疫苗上市后疑似预防接种异常反应监测数据分析

目的 对辽宁省2017-2019年肠道病毒71型(enterovirus type,EV71)灭活疫苗上市后疑似预防接种异常反应(adverse event following immunization,AEFI)监测数据进行分析,评价其预防接种安全性.方法 收集中国免疫规划信息管理系统中EV71 疫苗AEFI 监测数...     

Dietary Fish Oil Alters DNA Methylation of Genes Involved in Polyunsaturated Fatty Acid Biosynthesis in Muscle and Liver of Atlantic Salmon (Salmo salar)

Adequate dietary supply of eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) is required to maintain health and growth of Atlantic salmon (Salmo salar). However, salmon can also convert α-linolenic acid (18:3n-3) into eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) by sequential desaturation and elongation reactions, which can be modified by 20:5n-3 and 22:6n-3 intake. In mammals, dietary 20:5n-3 + 22:6n-3 intake can modify Fads2 expression (Δ6 desaturase) via altered DNA methylation of its promoter. Decreasing dietary fish oil (FO) has been shown to increase Δ5fad expression in salmon liver. However, it is not known whether this is associated with changes in the DNA methylation of genes involved in polyunsaturated fatty acid synthesis. To address this, we investigated whether changing the proportions of dietary FO and vegetable oil altered the DNA methylation of Δ6fad_b, Δ5fad, Elovl2, and Elovl5_b promoters in liver and muscle from Atlantic salmon and whether any changes were associated with mRNA expression. Higher dietary FO content increased the proportions of 20:5n-3 and 22:6n-3 and decreased Δ6fad_b mRNA expression in liver, but there was no effect on Δ5fad, Elovl2, and Elovl5_b expression. There were significant differences between liver and skeletal muscle in the methylation of individual CpG loci in all four genes studied. Methylation of individual Δ6fad_b CpG loci was negatively related to its expression and to proportions of 20:5n-3 and 22:6n-3 in the liver. These findings suggest variations in dietary FO can induce gene-, CpG locus-, and tissue-related changes in DNA methylation in salmon.     

水热处理过程中伊敏褐煤微观结构的演变规律

褐煤水热处理可以脱除有害元素,降低n(O)/n(C)比,提高煤阶,有利于煤的洁净利用。利用高压反应釜对褐煤进行水热处理,采用拉曼光谱(Raman)和傅立叶红外光谱(FTIR)对处理后的煤样的化学结构进行分析,探索了不同温度水热处理后煤样微观结构的演变规律。结果表明:150℃水热处理时部分含氧官能团脱除,同时,部分脂肪族侧链断裂及不稳定大分子芳环结构分解形成小分子芳环结构,部分CO分解形成各类醚和羟基;当水热温度升至200℃,处理后褐煤的芳香度指数(R)和芳香结构稠合指数(DOC)上升,表明煤内缩合结构增加,同时,缺陷结构和杂环被去除,大分子芳环结构相对增加,CO大量分解;水热温度继续升高至250℃,褐煤发生氢转移反应导致脂肪族侧链增加;当水热温度达到300℃时,褐煤的芳环结构被破坏,交联结构和无定形碳增加。     

Alkaline-Earth Tungstates: Equilibrium and Stability in the M-W-O Systems

Phase relations in the systems alkaline earth oxide-tungsten trioxide and their stability with metallic tungsten were investigated by the quenching technique using sealed capsules. In the system BeO-WO₂, no intermediate compounds were formed. Binary mixtures resulted in a eutectic at 1185°C and 37 mole % BeO. In the system MgO-WO₃, the 1:1 compound was stable and melted congruently at 1358°C. There are two crystalline modifications of this compound. The well-known wolframite-type form is stable below 1165°C. Two eutectics were found: 1120°C and 28.5 mole % MgO and 1318°C and 55.0 mole % MgO. In the systems CaO-WO₃, SrO-WO₃, and BaO-WO₃, two binary compounds are stable. The 1:1 compounds with the scheelite-type structure melt, respectively, at 1580°, 1535°, and 1475°C, and form eutectics with WO₃ at 1135°, 1073°, and 935°C, all with a eutectic composition near 75 mole % WO₃. The 3:1 compounds having the distorted (NH,)₃FeF₆-type structure melt at ∼2250°, 2225°, and 1795°C. The eutectics between these two compounds are at 1490°C and 56.5 mole % CaO, 1410°C and 57.0 mole % SrO, and 1320°C and 58.2 mole % BaO. Phase transformations to an ideal (NH₄)₃FeF₆-type structure in Sr₃WO₆ and Ba₃WO₆, were observed at 1100° and 805° C, respectively, by application of both high-temperature X-ray diffraction and DTA. At 1700°C, metallic tungsten exists in equilibrium with liquid, the alkaline earth oxides, W₁₈O₄₉, the 3:1 ternary oxides, and with combinations thereof.     

Phase Relations in the System Bi2O3-WO3

Phase relations in the system Bi₂O₃-WO₃ were studied from 500° to 1100°C. Four intermediate phases, 7Bi₂O₃· WO₃, 7Bi₂O₃· 2WO₃, Bi₂O₃· WO₃, and Bi₂O₃· 2WO₃, were found. The 7B₂O · WO₃ phase is tetragonal with a ₀= 5.52 Å and c ₀= 17.39 Å and transforms to the fcc structure at 784°C; 7Bi₂O₃· 2WO₃ has the fcc structure and forms an extensive range of solid solutions in the system. Both Bi₂O₃· WO₃ and Bi₂O₃· 2WO₃ are orthorhombic with (in Å) a ₀= 5.45, b ₀=5.46, c ₀= 16.42 and a ₀= 5.42, b ₀= 5.41, c ₀= 23.7, respectively. Two eutectic points and one peritectic exist in the system at, respectively, 905°± 3°C and 64 mol% WO₃, 907°± 3°C and 70 mol% WO₃, and 965°± 5°C and 10 mol% WO₃.     

An Ultrasonic Evaluation and Quality Control Tool for Adhesive Bonds

The problem of predicting adhesive bond performance for both surface preparation and undercure defects has been studied using an ultrasonic, experimental test bed system. This experimental test bed incorporates the ultrasonic and computer equipment necessary to acquire and process data from various types of adhesively bonded test specimens. The computer hardware and software has been developed to allow the design of reliable pattern recognition algorithms for the evaluation of surface preparation and bond cure. The specific problem studied is the inspection of the adhesive bond in an aluminum to aluminum step-lap joint whose strength could be affected by improper surface preparation or undercure. A set of 154 bond specimens was used to design an algorithm that is 91% reliable for separating the specimens into a good class, those bonds with no defects, or a weak class, bonds with poor surface preparation or undercured adhesive layer. A Fisher Linear Discriminant function was selected by the test bed as the best pattern recognition routine for this classification problem.     

低温流动性改进剂对低凝柴油性能的影响

通过考察几种低温流动性改进剂的活加量对常一线馏分、常二线馏分、常三线馏分、催化轻柴油等基础调合组分以及成品柴油冷滤点的影响,对以华北油田原油为原料生产低凝柴油的油品调合进行了研究。结果表明Ｄｏｄｉｆｌｏｗ４１３８和ＰＳＭ可做为华北石油管理局第一炼油厂生产柴油时的低温流动性改进剂,并确定了两种适宜的柴油生产方案。     

生物炭吸附去除水中有机污染物的研究进展

生物炭由于具有发达的孔隙结构以及表面富含多种官能团,对各种污染物均具有良好的吸附性能,因此被广泛应用于土壤污染修复和水体净化等领域,其中采用生物炭吸附去除水体中有机污染物成为近年来的研究热点之一。主要从生物炭材料的制备及吸附水中有机污染物的应用、吸附机制、影响因素等几个方面进行了综述,并对生物炭吸附的未来研究方向进行了初步探讨。     

基于RBF神经网络的柴油机整体性能预测

对于船用大功率柴油机而言,监测信息的复杂性、不确定性较为明显,为了准确地对柴油机性能作出预测,本文对柴油机振动信号进行处理分析,选取合适的特征参量,建立RBF神经网络模型来预报柴油机的状态.采用这种方法提高了预报精度,缩短了预测时间,取得了较好的预报效果.     

建筑类项目节能评估报告编制探讨

建筑类项目节能评估除体现全面性和深度外,还要针对建筑用能特点进行分析,作为评估结论的重要依据。在编制建筑类项目节能评估报告过程中,总结了该类型报告的主要内容,分析了一些容易出现的问题,并提出两点建议,以期对建筑类项目节能评估报告的编制提供一定的借鉴作用。