基于形态特征提取的急性下壁心肌梗死BiLSTM网络辅助诊断算法

急性下壁心肌梗死是一种病发急、进展快、致死率高的心脏疾病,该文提出一种新颖的基于形态特征提取的BiLSTM神经网络分类的急性下壁心肌梗死辅助诊断算法,可大幅度提高医生对急性下壁心肌梗死疾病的诊断效率并有助于及时确诊.算法包括:对胸痛中心数据库心拍信号进行降噪及心拍分割;根据临床心内科医学诊断指南提取了12导联波形距离特征和分导联波形幅值特征;依据提取的特征搭建LSTM与BiLSTM神经网络进行心拍的分类识别;使用PTB公开数据库和胸痛中心数据库多临床中心进行交叉验证.实验结果表明,加入胸痛中心真实临床数据后,基于形态特征提取BiLSTM神经网络的急性下壁心肌梗死辅助诊断算法准确率达到99.72％,精度达到99.53％,灵敏度达到100.00％,同时F1-Score达到99.76.该算法比其他现有算法准确率提高至少1％,该项研究具有非常重要的临床应用价值.     

Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model

This study investigated the inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products (fAGEs) formation in a bovine serum albumin (BSA)–fructose model. Model systems of BSA and fructose were prepared, and curcumin or piperine was added. fAGEs and BSA oxidation product (dityrosine, kynurenine and N'-formylkynurenine) contents were determined. The results showed that fAGEs content decreased with increasing concentration of curcumin and piperine (P < 0.05). Addition of curcumin and piperine at 160 µg mL⁻¹ could inhibit fluorescent AGEs by 100% and 93% respectively. Dityrosine and N'-formylkynurenine contents decreased as curcumin and piperine concentration increased (P < 0.05). Furthermore, the result of principal component analysis indicated that curcumin and piperine markedly impeded BSA oxidation, resulting in a lower level of fAGEs in model systems. Therefore, adding curcumin and piperine may facilitate reduced fAGEs levels in BSA–fructose model.     

Fabrication of crescent-shaped ceramic microparticles based on single emulsion microfluidics

Ceramic microparticles have great potentials in various fields such as materials engineering, biotechnology, microelectromechanical systems, etc. Morphology of the microparticle performs an important role on their application. To date, it remains difficult to find an effective and controllable way for fabricating nonspherical ceramic microparticles with 3D features. This work demonstrates a method that combines UV light lithography and single emulsion opaque-droplet-templated microfluidic molding to prepare the crescent-shaped ceramic microparticles. By tailoring the intensity of UV light and flow rate of fluid, the shapes of microparticles are accordingly tuned. Therefore, varieties of crescent-shaped microparticles and their variations have been fabricated. After sintering, the crescent-shaped alumina ceramic microparticles were obtained. Benefitting from the light absorption and scattering behavior of most ceramic nanoparticles, this system can serve as a general platform to produce crescent-shaped microparticles made from different materials, and hold great potentials for applications in microrobotics, structural materials in MEMS, and biotechnology.     

TEMPO氧化修饰的天然多糖纳米纤维增强复合材料及其功能化研究进展

纤维素和几丁质具有相似的结构，是自然界中储量丰富的两类天然多糖。经2, 2, 6, 6-四甲基哌啶氮氧化物(TEMPO)氧化修饰制备的纤维素和几丁质纳米纤维，不仅具有多糖类物质的良好亲水性、生物可降解性、生物相容性及丰富的官能团(羟基、羧基、乙酰氨基和氨基等)所带来的特定化学性质，而且还具有纳米纤维的纳米尺寸效应、大比表面积、高表面活性、高结晶度和手性液晶相结构等特点，已成为生物质纳米材料领域的研究重点之一。本文对TEMPO氧化修饰制备天然多糖纳米纤维的方法及剥离机制进行了总结，同时重点综述了TEMPO氧化修饰的天然多糖纳米纤维在薄膜、凝胶、导电、医用、电磁屏蔽及环境等复合材料的增强和功能升级等方面的研究进展，强调了纤维素和几丁质纳米纤维的官能团及纳米尺寸在复合材料中的增效机制。最后，对天然多糖纳米纤维的发展方向及其在各领域应用的机遇与挑战进行了展望。     

Synthesis of Hollow Three-Dimensional Channels LiNi_(0.5)Mn_(1.5)O_4 Microsphere by PEO Soft Template Assisted with Solvothermal Method

A appropriate size with three-dimension(3 D) channels for lithium diffusion plays an important role in constructing highperforming LiNi_(0.5)Mn_(1.5)O_4(LNMO) cathode materials, as it can not only reduce the transport path of lithium ions and electrons, but also reduce the side effects and withstand the structural strain in the process of repetitive Li~+ intercalation/deintercalation. In this work, an e fficient method for designing the hollow LNMO microsphere with 3 D channels structure by using polyethylene oxide(PEO) as soft template agent assisted solvothermal method is proposed. Experimental results indicate that PEO can make the reagents mingle evenly and nucleate slowly in the solvothermal process, thus obtaining a homogeneous distribution of carbonate precursors. In the final LNMO products, the hollow 3 D channels structure obtained by the decomposition of PEO and carbonate precursor in the calcination can provide abundant electroactive zones and electron/ion transport paths during the charge/discharge process, which benefits to improve the cycling performance and rate capability. The LNMO prepared by adding 1 g PEO possesses the most outstanding electrochemical performance, which presented an excellent discharge capacity of 143.1 mAh g~(-1) at 0.1 C and with a capacity retention of 92.2% after 100 cycles at 1 C. The superior performance attributed to the 3 D channels structure of hollow microspheres, which provide uninterrupted conductive systems and therefore achieve the stable transfer for electron/ion.     

Fabrication of barium titanate ceramics via digital light processing 3D printing by using high refractive index monomer

A digital light processing (DLP) technology has been developed for 3D printing lead-free barium titanate (BTO) piezoelectric ceramics. By comparing the curing and rheological properties of slurries with different photosensitive monomer, a high refractive index monomer acryloyl morpholine (ACMO) was chosen, and a design and preparation method of BTO slurry with high solid content, low viscosity and high curing ability was proposed. By further selecting the printing parameters, the single-layer exposure time was reduced and the forming efficiency has been greatly improved. Sintered specimens were obtained after a nitrogen-air double-step debinding and furnace sintering process, and the BTO ceramics fabricated with 80 wt% slurry shows the highest relative density (95.32 %) and piezoelectric constant (168.1 pC/N). Furthermore, complex-structured BTO ceramics were prepared, impregnated by epoxy resin and finally assembly made into hydrophones, which has significance for the future design and manufacture of piezoelectric ceramic-based composites that used in functional devices.     

High-temperature oxidation behavior of monolithic Zr3[Al(Si)]4C6 and its composite incorporating 30vol% ZrB2-SiC: Providing a basis for broadening the service temperature

To provide a basis for the high-temperature oxidation of ultra-high temperature ceramics (UHTCs), the oxidation behavior of Zr₃[Al(Si)]₄C₆ and a novel Zr₃[Al(Si)]₄C₆-ZrB₂-SiC composite at 1500 °C were investigated for the first time. From the calculation results, the oxidation kinetics of the two specimens follow the oxidation dynamic parabolic law. Zr₃[Al(Si)]₄C₆ exhibited a thinner oxide scale and lower oxidation rate than those of the composite under the same conditions. The oxide scale of Zr₃[Al(Si)]₄C₆ exhibited a two-layer structure, while that of the composite exhibited a three-layer structure. Owing to the volatilization of B₂O₃ and the active oxidation of SiC, a porous oxide layer formed in the oxide scale of the composite, resulting in the degradation of its oxidation performance. Furthermore, the cracks and defects in the oxide scale of the composite indicate that the reliability of the oxide scale was poor. The results support the service temperature of the obtained ceramics.     

Optical design of the Lyman alpha based beam emission spectroscopy(LAB)diagnostic on the HL-2A tokamak

In this article, we present the optical design of a novel diagnostic on the HL-2 A tokamak, i.e. the20-channel edge Lyman-alpha beam emission spectroscopy, which is a promising solution for edge density turbulence research on tokamaks, as it offers the possibility of density fluctuation measurement with a 3.3 mm spatial resolution while maintains a high temporal resolution of1 μs. The optical path, including the reflective collection optics, the high-dispersion spectrometer, and the linear detector array, is carefully optimized to obtain a good image quality and a high throughput. The maximum root mean square radius of the collection optics is 64 μm.The detected photon flux is estimated to be about 10~(11) photons/s/channel.     

矢量语音传感器微阵列

人工智能的普及促进了语音交互技术的发展,语音传感器阵列作为智能语音交互的硬件前端,成为语音交互领域的前沿研究方向.矢量语音传声器自有的偶极子指向性、零点深度以及阵列体积小便于集成的特点特别符合语音交互技术对硬件设备的要求.基于此,通过采用两组矢量敏感单元"共点正交"形成矢量微阵列实现声源空间锐化波束指向,其不受瑞利限与空间采样率限制,与传统空间离散分布的声压麦克风阵列有着本质区别,是矢量微阵列的核心优势所在.矢量微阵列传声器弥补了现有双麦阵列的不足,具有更为广阔的应用前景,作为智能语音交互的硬件前端,对推动智能语音交互领域的发展具有重要意义.     

传统牦牛酸奶源高产胞外多糖乳酸菌特性及发酵性能

为了研究四川藏区传统牦牛酸奶中高产胞外多糖乳酸菌特性及发酵性能，以本实验室分离出的六株高产胞外多糖乳酸菌为研究对象，以菌株生长量、耐酸性、胆盐耐受力、渗透压耐受力和细胞表面疏水性为指标进行特性研究；以发酵酸奶的凝乳时间、持水力、酸化及后酸化能力、挥发性物质及质构等为指标进行发酵性能研究。菌株的生长曲线表明，6株菌株分别在14 h（218、276、266）、16 h（271、285、231）进入对数生长稳定期，其中编号218的菌株生长量最高，OD值为2.188。耐受性实验结果表明，菌株276具有良好的耐酸能力（P<0.05）；菌株266、218、231耐胆盐的能力较强；6株菌株均具有较好的耐渗透压的能力，其中菌株285对高渗透压的耐受性较强；菌株285和218在两种有机试剂中的疏水性均显著（P<0.05）高于其他菌株，且与十六烷的结合效果较好。发酵试验结果表明，6株菌株所发酵酸奶均在6~8 h内凝固，酸乳在冷藏期间，活菌数均保持在107 CFU/mL以上，均符合发酵剂的标准，其中菌株276的最高为3.22×106 CFU/mL；菌株218发酵制得的酸奶质构特性较好，持水力和酸化能力较其余菌株均最强，分别为60.98%和83 °T；菌株276、266抗后酸化能力较好；菌株231产香性能最优，乙醛含量为24~26 μg/mL，双乙酰含量为1.58~3.73 μg/mL，能够明显改善酸奶的风味。通过综合比较6株高产胞外多糖乳酸菌特性及发酵性能，菌株218为一株性能良好、具有良好稳定性的菌株，可作为乳酸菌发酵剂且具有一定的应用潜力。研究为利用四川藏区传统牦牛酸奶中分离出的高产胞外多糖乳酸菌在发酵乳制品的应用提供理论依据。