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EG Diego González A Méndez Lanza JA Mosquera Pesta?a 《Canadian Metallurgical Quarterly》1996,13(9):430-433
Whether a sulfonylurea may be used together with insulin for treating NIDDM has been controversial. One view, based on older studies, has been that the additional benefit is too small or the level of glucose control achieved usually too poor to recommend this method. More recent studies of a more specific way of combining a sulfonylurea with insulin are more supportive. When a single injection of insulin taken in the evening is added to a sulfonylurea at the time of secondary failure of the sulfonylurea alone, glycemic control is quite simply and consistently restored to acceptable levels. At this time in the natural history of NIDDM, evening insulin combined therapy is more effective than a single injection of insulin alone, and just as effective as a more complex multiple-injection regimen without an oral agent. A recent multicenter trial of a new sulfonylurea, glimepiride, in combination with a single injection of 70/30 insulin before dinner has confirmed that this approach is safe and more consistently effective than insulin alone for obese patients beginning insulin in a setting resembling clinical practice. The available evidence suggests this form of combined therapy is suitable for routine use. 相似文献
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125.
J. Villalba E.L. Zapata E. Antelo J.D. Bruguera 《The Journal of VLSI Signal Processing》1998,19(2):127-147
In this work we extend the radix-4 CORDIC algorithm to the vectoring mode (the radix-4 CORDIC algorithm was proposed recently by the authors for the rotation mode). The extension to the vectoring mode is not straightforward, since the digit selection function is more complex in the vectoring case than in the rotation case; as in the rotation mode, the scale factor is not constant. Although the radix-4 CORDIC algorithm in vectoring mode has a similar recurrence as the radix-4 division algorithm, there are specific issues concerning the vectoring algorithm that demand dedicated study. We present the digit selection for nonredundant and redundant arithmetic (following two different approaches: arithmetic comparisons and table look-up), the computation and compensation of the scale factor, and the implementation of the algorithm (with both types of digit selection) in a word-serial architecture. When compared with conventional radix-2 (redundant and non-redundant) architectures, the radix-4 algorithms present a significant speed up for angle calculation. For the computation of the magnitude the speed up is very slight, due to the nonconstant scale factor in the radix-4 algorithm. 相似文献
126.
K Sugiura M Inaba H Hisha K Borisov EE Sardi?a RA Good S Ikehara 《Canadian Metallurgical Quarterly》1997,15(6):461-468
The objectives of this study were 1) to evaluate interleukin-8 concentrations in cervical secretions in predicting preterm delivery, microbial invasion of the amniotic cavity and histologic chorioamnionitis in patients with preterm labor and intact membranes and 2) to compare the diagnostic value of interleukin-8 with fetal fibronectin determinations in predicting preterm delivery, microbial invasion of the amniotic cavity and histologic chorioamnionitis in patients with preterm labor and intact membranes. Interleukin-8 and fetal fibronectin were assayed in cervical secretions in 106 patients with singleton pregnancies and intact membranes admitted for preterm labor. Amniotic fluid obtained by amniocentesis was cultured and placentas (No = 43) analyzed for the presence of chorioamnionitis. The prevalence of pregnancies delivered preterm was 46.2% (49/106) and 15.09% (16/106) of amniotic fluid cultures were positive. Interleukin-8 levels in cervical secretions were significantly increased in patients who delivered preterm (p < or = 0.0001), in presence of positive amniotic fluid culture (p = 0.0016) and histological chorioamnionitis (p = 0.008) than in patients with negative findings. Receiver-operator characteristics curve analysis showed that an interleukin-8 value > 450 pg/ml is comparable to that of a fetal fibronectin value > 50 ng/ml in predicting preterm delivery (p = 0.247). Among patients who delivered preterm interleukin-8 concentrations > 860 pg/ml predicted a positive amniotic fluid culture with a sensitivity of 81.2% and a specificity 66.6%. Further, in patients who delivered preterm and had a negative amniotic fluid culture, IL-8 concentrations > 480 pg/ml predicted histological chorioamnionitis with a sensitivity 78.5% and specificity 61.5%. A positive fetal fibronectin > 50 ng/ml was not predictve of either a positive amniotic fluid culture or the presence of histological chorioamnionitis. In conclusion, increased concentrations of interleukin-8 and fetal fibronectin are associated with impending delivery and their diagnostic value seems comparable. However, interleukin-8 concentrations identify patients at risk of a positive amniotic fluid culture and the presence of histological chorioamnionitis. Measurement of interleukin-8 in cervical secretion is a non-invasive method to identify patients at risk for both preterm delivery and intrauterine infection. 相似文献
127.
J Caballero Güeto R Arana G Calle FJ Caballero Güeto E García del Río M Sancho C Pi?ero 《Canadian Metallurgical Quarterly》1997,50(12):906-908
Propionibacterium acnes is often considered to be a contaminant but it has also been found to be the principal pathogen in serious infections. P. acnes is a rare cause of infective endocarditis. It has been suggested that aortic root abscesses are caused by bacteria that are particularly virulent. The strongest risk factor for serious infections by this bacteria is the presence of foreign bodies. A case is presented in which endocarditis of a native aortic valve caused by P. acnes was associated with an aortic root abscess. Transesophageal echocardiography is particularly helpful in the diagnosis of this severe complication of infective endocarditis. The literature for P. acnes endocarditis is reviewed. 相似文献
128.
An overview of FDA medical device regulation as it relates to deep brain stimulation devices. 总被引:1,自引:0,他引:1
Carlos Pe?a Kristen Bowsher Ann Costello Robert De Luca Sara Doll Khan Li Marie Schroeder Theodore Stevens 《IEEE transactions on neural systems and rehabilitation engineering》2007,15(3):421-424
The United States Food and Drug Administration (FDA) is charged with assuring the safety and effectiveness of a variety of medical products and the FDA's Center for Devices and Radiological Health is responsible for premarket and postmarket regulation of medical devices. In this paper, we review--from device classification and clinical studies to the final marketing application--FDA's premarket requirements and postmarket requirements as they relate to deep brain stimulation devices. 相似文献
129.
The effects of cooking temperature, time and temperature of brine-salting, and temperature of ripening on the behavior of Enterobacteriaceae in Manchego cheese were studied. Fifty lots of cheese from raw ewe's milk manufactured and ripened under different conditions were investigated throughout a 60-day ripening period. Differences in pH values due to temperature-dependent whey retention accounted for the effect of cooking temperature on coliform and fecal coliform counts. Temperature of brine-salting had no effect on Enterobacteriaceae counts, but a significant effect of salting time on Enterobacteriaceae and fecal coliform counts was detected. Ripening temperature was the manufacturing variable with greatest influence (P<.01) on Enterobacteriaceae and coliform counts during the whole curing period. 相似文献
130.
P Sánchez García 《Canadian Metallurgical Quarterly》1997,114(1):157-63; discussion 164-7