酞菁光敏剂对S180移植瘤的疗效

研究了GaS_4PC,ZnS_2PC两种酞菁在激光照射下对S180肉瘤的疗效,并讨论了其他酞菁光敏剂对癌细胞的杀伤效果。     

Pulmonary carcinogenicity of relatively low doses of beta-particle radiation from inhaled 144CeO2 in rats

This study was conducted to examine the carcinogenic effects of inhaled beta-particle-emitting radionuclides, particularly in lower dose regions in which there were substantial uncertainties associated with available information. A total of 2751 F344/N rats (1358 males and 1393 females) approximately 12 weeks of age at exposure were used. Of these, 1059 rats were exposed to aerosols of 144CeO2 to achieve mean desired initial lung burdens (ILBs) of 18 kBq (low level), 247 rats to achieve mean ILBs of 60 kBq (medium level) and 381 rats to achieve mean ILBs of 180 kBq (high level). Control rats (total of 1064) were exposed to aerosols of stable CeO2. Based on the 95% confidence intervals of the median survival times and the cumulative survival curves, there were no significant differences in the survival of groups of female and male exposed rats relative to controls. The mean lifetime beta-particle doses to the lungs of the rats in the four groups were: low level, 3.6 +/- 1.3 (+/-SD) Gy; medium level, 12 +/- 4.5 Gy; and high level, 37 +/- 5.9 Gy. The crude incidence of lung neoplasms increased linearly with increasing doses to the lungs (controls, 0.57%; low level, 2.0%; medium level, 6.1%; and high level, 19%). The estimated linear risk coefficients for lung neoplasms per unit of dose to the lung were not significantly different for the three dose levels studied. The risk coefficient at the lower level was 39 +/- 14 (+/-SE) excess lung neoplasms per 10(4) rat Gy; at the medium level the risk was 47 +/- 12; and at the higher level the risk was 50 +/- 9.0. The relationship of beta-particle dose to the lung and the crude incidence of lung neoplasms was described adequately by a linear function. We concluded that the risk of lung neoplasms in rats per unit of radiation dose did not increase with decreasing mean beta-particle dose to the lung over the range of 3.6 to 37 Gy. The weighted average of these three values was 47 +/- 6.4 (+/-SE) excess lung neoplasms per 10(4) rat Gy. To extend the risk coefficients for lung neoplasms to lower doses by experimentation will require much larger numbers of rats than used in this study.     

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

A DNA fragment containing the recA gene of Gluconobacter oxydans was isolated and further characterized for its nucleotide sequence and ability to functionally complement various recA mutations. When expressed in an Escherichia coli recA host, the G. oxydans recA protein could efficiently function in homologous recombination and DNA damage repair. The recA gene's nucleotide sequence analysis revealed a protein of 344 amino acids with a molecular mass of 38 kDa. We observed an E. coli-like LexA repressor-binding site in the G. oxydans recA gene promoter region, suggesting that a LexA-like mediated response system may exist in G. oxydans. The expression of G. oxydans recA in E. coli RR1, a recA+ strain, surprisingly caused a remarkable reduction of the host wild-type recA gene function, whereas the expression of both Serratia marcescens recA and Pseudomonas aeruginosa recA gene caused only a slight inhibitory effect on function of the host wild-type recA gene product. Compared with the E. coli RecA protein, the identity of the amino acid sequence of G. oxydans RecA protein is much lower than those RecA proteins of both S. marcescens and Pseudomonas aeruginosa. This result suggests that the expression of another wild-type RecA could interfere with host wild-type recA gene's function, and the extent of such an interference is possibly correlated to the identity of the amino acid sequence between the two classes of RecA protein.     

LD泵浦的Nd∶YAG腔内倍频激光器及其模式

用KTP晶体研制成LD泵浦的YAG腔内倍频激光器,得到0.532μm连续绿色线偏振激光输出,阈值泵浦功率为41mW,输出功率为1.4mW,斜效率为1.7％。研究了泵浦光对倍频激光横模的影响。     

天津市正常人全血和血清微量元素含量分析

人体内微量元素含量平衡与否与人体健康状态有着密切关系已为大量实践所证实。人体血液中微量元素的正常值测定是研究人体健康与微量元素关系的一项基础性工作,本文提供了天津市正常人全血及血清中几种微量元素含量的数据。     

Nuclear proteins from liver and kidney bind a 37 bp sequence in the 5' upstream region of the mGAT1 gene

The mouse GABA transporter (mGAT1) gene has been shown to be exclusively expressed in brain by Northern and Western blot analyses. The interactions between the 5' flanking region of the mGAT1 gene and nuclear proteins from different mouse tissues were studied by means of gel-shift assay. Our results show that nuclear protein factors from non-nervous tissues can specifically recognize a 37 bp sequence that is conserved in the 5' flanking region between the human and mouse GAT1 genes. Similar nuclear protein factors were also found to exist in rat, rabbit and pig.     

复杂场景实时目标检测方法

针对含有非平稳背景的复杂场景,提出一种基于空间混合高斯模型的实时目标检测方法.该方法以混合高斯模型作为颜色分布的统计框架,并在空间邻域中利用背景与前景隶属度之间的竞争确定像素的归属,提高了检测准确率;同时通过基于偏差均值的匹配判断和低权重模型的移除提升了混合高斯统计框架的性能,以实时地对运动目标进行准确的检测.实验结果表明,文中方法对非平稳背景有很好的适应能力,在检测准确率和运行效率上均优于其他检测方法.     

遥感数据时空融合技术在农作物监测中的适应性研究

受卫星回访周期及云的影响,大范围研究区同一时期的Landsat卫星数据很难获取,因而国内外学者提出了遥感影像时空融合技术。以石河子为实验区,利用STARFM(Spatial and Temporal Adaptive Reflectance Fusion Model)模型融合生成了高时空分辨率TM影像,对不同作物类型真实反射率与融合影像反射率作相关性分析,分析了遥感数据时空融合技术在新疆农作物监测中的适用性。结果表明:利用STARFM模型模拟得到的融合影像与真实影像间的相关性较高,但当地物类型发生变化时,融合影像与真实影像间将存在明显的差异。地物类型变化作物融合影像反射率与真实影像反射率间的相关性较小。     

自适应回声对消的初期迭代统计学模型及改进算法

为减少滤波器长度,提出自适应滤波算法初期迭代统计学模型及改进的回声消除算法。提出的统计学模型分析了自适应算法迭代初期滤波器各系数的均值和方差。基于该模型提出的改进算法,先检测回声路径峰值,进而确定回声路径延时,然后以延时为中心,用一个短的滤波器辨识原回声路径活跃系数部分。用实际回声路径进行仿真,理论和实验结果均表明,新算法在迭代的前75～100步已可准确检测回声路径峰值并确定延时;而减少滤波器长度,可大幅提高自适应算法收敛速度并降低算法计算复杂度。     

用微型计算机分析高层框架及框-剪结构体系的位移迭代法

本文用位移迭代法与电算技术相结合的方式,研究出高层框架、框剪、框架联肢墙等结构的精确而又简便的计算方法。在内力分析中考虑了柱的轴变效应,剪力墙的剪切变形,联肢剪力墙横梁刚域等对结构内力及位移的影响。由于按照结点编号自动形成迭代公式,可节省计算机内存及时间。因此用微机如PC-1500即能够分析高层框-剪结构。应用本文中的方法编制的程序“ITAN-1”计算了几个数例,结果令人满意,说明本文方法具有一定的实用性。