Neuropsychological impairment, depression, and Parkinson's disease.

Examined the nature of cognitive impairment in Parkinson's disease (PD) and its relation to depression in 89 nondemented (mean age 69.35 yrs) and 19 demented (mean age 79.94 yrs) PD patients and 64 control Ss (mean age 66.44 yrs). PD Ss were significantly more depressed than controls on the Beck Depression Inventory and the Geriatric Depression Scale (GDS). There were significant, negative associations between scores on the GDS and performance on 8 neuropsychological test variables. Both PD groups were significantly impaired on 7 neuropsychologial test variables, including measures of visuomotor, memory, and executive functions. The demented PD group was more impaired than the nondemented PD and control groups on 9 neuropsychological test variables. Cognitive impairments in the nondemented PD group were relatively subtle and not apparent on the Mini-Mental State Examination. (PsycINFO Database Record (c) 2010 APA, all rights reserved)