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31.
OBJECTIVES: This study attempted to determine the effect of unreported patient deaths on estimates of pacemaker reliability. BACKGROUND: The reliability of pacemakers is usually reported with reference to implant registration data and returned product analysis without censoring when follow-up data are missing. METHODS: We studied 73 patients (mean [+/- SD] age 77 +/- 8 years) undergoing implantation of a ventricular-inhibited (VVI) pacemaker who were subsequently found to be at increased risk of experiencing premature pacemaker failure. Survival curves for patients and pacemakers were constructed by the Kaplan-Meier method with appropriate censoring at the time of unrelated death or elective explantation of a normal device. To examine the effect of unreported loss of follow-up data, patient mortality was then ignored, and follow-up for pacemakers without known failure was assumed to continue to the date of analysis. RESULTS: There were 13 device failures, with a median pacemaker survival time of 37 months. Twenty-three patients died, all of causes unrelated to the pacemaker system; median patient survival time was only 44 months. Ignoring this attrition inflated follow-up time from 122 to 188 patient-years and reduced the apparent pacemaker failures at 30 months by almost half, from 37% to only 20%. Modeling the process shows that when the patient mortality rate is more than half the pacemaker failure rate, ignoring censoring inflates the device survival estimate by > or = 10% from the median survival onward. CONCLUSIONS: When medical device survival curves are generated by implant registration data and returned product analysis, they should be adjusted for unreported loss of follow-up. 相似文献
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HL Rieder JM Watson MC Raviglione M Forssbohm GB Migliori V Schwoebel AG Leitch JP Zellweger 《Canadian Metallurgical Quarterly》1996,9(5):1097-1104
Consensus-based recommendations have been developed by a Working Group of the World Health Organization (WHO) and the European Region of the International Union Against Tuberculosis and Lung Disease (IUATLD) on uniform reporting of tuberculosis surveillance data in the countries of Europe. A uniform case definition and a minimum set of variables for reporting on each case have been agreed which, when collated on a national basis, will allow comparison of the epidemiology of tuberculosis in different European countries. The Working Group recommends that the case definition includes "definite" cases, where the diagnosis has been confirmed by culture (or supported by microscopy findings in countries where diagnostic culture facilities are not available), and "other than definite cases" based on a clinical diagnosis of tuberculosis combined with the intention to treat with a full course of antituberculosis therapy. Both "definite" and "other than definite" cases should be notified by physicians and, in addition, laboratories should be required to report "definite" cases. The minimum set of variables to be collected on each case of tuberculosis should include: date of starting treatment, place of residence, date of birth, gender, and country of origin, to characterize the patient. Recommended disease-specific variables include: site of disease, bacteriological status (microscopy and culture), and history of previous antituberculosis chemotherapy. The minimum set of variables should be collated on all patients and should be as complete as possible. Additional variables may be collected for individual, local or national purposes, but, in general, completeness of reporting on cases is likely to be better if the information requested is kept to a minimum. Timely reporting of cases is essential for appropriate public health action. Cases should be reported to the health authority at the local and/or regional level within 1 week of starting treatment. Individual-case based information should be reported to the national level by the local or regional level. Feedback to reporters is essential. At the national level, preliminary quarterly reports should be produced and final reports should be published annually. 相似文献
35.
Short-reach optical interconnects among massive serves in data centers have attracted extensive research recently. Increasing capacity, cost and power efficiency as well as wavelength switching between data center network nodes are still key challenges for current optical interconnects. In this work, we experimentally demonstrate the real-time inter-mode optical wavelength switching technique, for high-speed wavelength flexible data center interconnects. A 10 Gbit/s 1 550 nm single mode vertical cavity surface emitting laser (VCSEL) is optically injected and used to control a 10 Gbit/s multimode VCSEL carrier at 850 nm. Results show that a clearly open eye diagram is achieved at back-to-back analysis, implying a successful wavelength switch and error-free operation at 10 Gbit/s. A fully optical wavelength conversion of a multimode VCSEL operation at 850 nm using a single mode VCSEL subject to external optical injection at 1 550 nm is reported. This work opens new perspectives towards the development of a cost effective high-speed real-time inter-band wavelength switching technique between servers and network devices operating at different transmission windows at network nodes, for current and future optical interconnects. 相似文献
36.
ABSTRACTThis article investigates the reasons householders do, and don’t, adopt domestic rainwater harvesting (DRWH). Using a mixed-methods research approach, we collected data in three districts in central Uganda. Factors that emerged as important with respect to uptake of DWRH to address water shortage, especially at the household scale, include the work of intermediary organizations, finance mechanisms, life course dynamics and land tenure. 相似文献
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Dong-Feng Li Catrin M. Davies Shu-Yan Zhang Calum Dickinson Noel P. O’Dowd 《Acta Materialia》2013,61(10):3575-3584
The micromechanical deformation of an austenitic stainless steel under uniaxial tension at elevated temperature (550 °C) following room-temperature compression has been examined in this work. The study combines micromechanical finite-element modelling and in situ neutron diffraction measurements. Overall, good agreement has been achieved between the measured and simulated stress vs. lattice strain response, when prestrain is accounted for. The results indicate that the introduction of prestrain can significantly influence subsequent microscale deformation and damage development associated with microplasticity and that an appropriate representation of strain history can improve the predictive accuracy at the microscale for a polycrystalline material. 相似文献
39.
AG Leitch 《Canadian Metallurgical Quarterly》1976,3(5):447-454
The dosimetric characteristics of the electron beams from the Sagittaire (C.G.R. MeV) linear accelerator are presented. The variations in dose output with the distance from the source are indicated for the usual treatment distances. The measurements carried out demonstrating the deviations from the inverse square law for distances. The graphs for the variation in dose output in terms of the opening of the collimator are given for square and rectangular openings. The measurements demonstrate the preponderant influence of the short side 1 of the rectangular field of the relative variation in dose output. The variations in the graphs of the deep yield in terms of beam energy, distance from the source and field dimension were studied. For the different energies, the influence of the distance from the collimator and the dimension of the field on the dose at entry and on the depth of the maximum was shown. Measurements of the deep yields were carried out in the case of rectangular fields. In each case, the side of the equivalent square field corresponding to the same deep yield as a 1 X L rectangular field was determined; a comparison was carried out with the equivalent square field defined for colbat radiation. 相似文献
40.
Benjamin K.A. Thomson Shih‐Han S. Huang Rosemary E. Leitch Stephanie Dixon Paul Heidenheim Rita S. Suri Christopher T. Chan Robert M. Lindsay 《Hemodialysis international. International Symposium on Home Hemodialysis》2013,17(4):548-556
Sodium balance across a hemodialysis treatment influences interdialytic weight gain (IDWG), pre‐dialysis blood pressure, and the occurrence of intradialytic hypotension, which associate with patient morbidity and mortality. In thrice weekly conventional hemodialysis patients, the dialysate sodium minus pre‐dialysis plasma sodium concentration (δDPNa+) and the post‐dialysis minus pre‐dialysis plasma sodium (δPNa+) are surrogates of sodium balance, and are associated with both cardiovascular and all‐cause mortality. However, whether δDPNa+ or δPNa+ better predicts clinical outcomes in quotidian dialysis is unknown. We performed a retrospective analysis of clinical and demographic data from the Southwestern Ontario Regional Home Hemodialysis program, of all patients since 1985. In frequent nocturnal hemodialysis, δPNa+ was superior to δDPNa+ in predicting IDWG (R2 = 0.223 vs. 0.020, P = 0.002 vs. 0.76), intradialytic change in systolic (R2 = 0.100 vs. 0.002, P = 0.02 vs. 0.16) and diastolic (R2 = 0.066 vs. 0.019, P = 0.02 vs. 0.06) blood pressure, and ultrafiltration rate (R2 = 0.296 vs. 0.036, P = 0.001 vs. 0.52). In short hours daily hemodialysis, δDPNa+ was better than δPNa+ in predicting intradialytic change in diastolic blood pressure (R2 = 0.101 vs. 0.003, P = 0.02 vs. 0.13). However, δPNa+ was better than δDPNa+ in predicting IDWG (R2 = 0.105 vs. 0.019, P = 0.04 vs. 0.68) and pre‐dialysis systolic blood pressure (R2 = 0.103 vs. 0.007, P = 0.02 vs. 0.82). We also found that the intradialytic blood pressure fall was greater in frequent nocturnal hemodialysis patients than in short hours daily patients, when exposed to a dialysate to plasma sodium gradient. These results provide a basis for design of prospective trials in quotidian dialysis modalities, to determine the effect of sodium balance on cardiovascular outcome. 相似文献