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排序方式: 共有422条查询结果,搜索用时 15 毫秒
91.
92.
Camila I. Irion Monique Williams Jose Condor Capcha Trevor Eisenberg Guerline Lambert Lauro M. Takeuchi Grace Seo Keyvan Yousefi Rosemeire Kanashiro-Takeuchi Keith A. Webster Karen C. Young Joshua M. Hare Lina A. Shehadeh 《International journal of molecular sciences》2022,23(12)
Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pathologies, but its application to AS remains untested. This study investigates cardiorespiratory function and SGLT2 renal expression in Col4a3-/- mice from three different genetic backgrounds, 129x1/SvJ, C57Bl/6 and Balb/C. male Col4a3-/- 129x1/SvJ mice displayed alterations consistent with heart failure with preserved ejection fraction (HFpEF). Female, but not male, C57Bl/6 and Balb/C Col4a3-/- mice exhibited mild changes in systolic and diastolic function of the heart by echocardiography. Male C57Bl/6 Col4a3-/- mice presented systolic dysfunction by invasive hemodynamic analysis. All strains except Balb/C males demonstrated alterations in respiratory function. SGLT2 expression was significantly increased in AS compared to WT mice from all strains. However, cardiorespiratory abnormalities and SGLT2 over-expression were significantly less in AS Balb/C mice compared to the other two strains. Systolic blood pressure was significantly elevated only in mutant 129x1/SvJ mice. The results provide further evidence for strain-dependent cardiorespiratory and hypertensive phenotype variations in mouse AS models, corroborated by renal SGLT2 expression, and support ongoing initiatives to develop SGLT2 inhibitors for the treatment of AS. 相似文献
93.
As water-based extraction technologies for producing bitumen from oil sands have received increasing environmental concerns,developing non-aqueous extraction (N... 相似文献
94.
k-nearest neighbor (k-NN) queries are well-known and widely used in a plethora of applications. However, in the original definition of k-NN queries there is no concern regarding diversity of the answer set with respect to the user’s interests. For instance, travelers may be looking for touristic sites that are close to where they are, but that would also lead them to see different parts of the city. Likewise, if one is looking for restaurants close by, it may be more interesting to learn about restaurants of different categories or ethnicities which are nonetheless relatively close. The interesting novel aspect of this type of query is that there are two competing criteria to be optimized: closeness and diversity. We propose two approaches that leverage the notion of linear skyline queries in order to find the k diverse nearest neighbors within a radius r from a given query point, or (k, r)-DNNs for short. Our proposed approaches return a relatively small set containing all optimal solutions for any linear combination of the weights a user could give to the two competing criteria, and we consider three different notions of diversity: spatial, categorical and angular. Our experiments, varying a number of parameters and exploring synthetic and real datasets, in both Euclidean space and road networks, respectively, show that our approaches are several orders of magnitude faster than a straightforward approach. 相似文献
95.
Cruz Maria Camila Sánchez-Velandia Julián E. Causíl Saleth Villa Aída Luz 《Catalysis Letters》2021,151(8):2279-2290
Catalysis Letters - Isomerization of β-pinene epoxide to perillyl alcohol using several materials based on titanium and molybdenum is reported. The metals were incorporated on SBA-15, MCM-41... 相似文献
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98.
Camila Pereda Daniel G. Actis Pedro Mendoza Zélis Vera A. Alvarez Laura M. Sanchez 《应用聚合物科学杂志》2021,138(16):50261
Magnetic beads composed by polyvinyl alcohol and iron oxides were developed and fully characterized. The materials were not only cross-linked by a physical treatment but also the magnetic nanoparticles (MNPs) are acting as cross-linking dots. Interestingly, the analysis of scanning electron micrographs revealed that, in the case of hydrated samples, flower-like structures (average diameter 6–9 μm) being constituted by MNPs were present, whereas when the beads were dried the MNPs structure changed to porous spheres (average diameter 2–3 μm). Some of the prepared materials were tested to determine their capability to act as water remediation devices, and good removal results were obtained toward both methylene blue (average removal efficiency higher than 80%) and methyl orange (average removal efficiency lower than 30%) adsorption. The experiments performed confirmed that the adsorbent, once the treatment has ended, can be removed off through the simple employment of a permanent magnet. 相似文献
99.
Tiago B. Ferreira Gabriel C. Rego Lucas R. Ramos Camila A. de Menezes Edson L. Silva 《国际能源研究杂志》2020,44(13):10442-10452
Sugarcane molasses is a carbohydrate-rich carbon source with potential to develop the biorefinery model in the sugarcane industry. Two of the most well-known renewable products from the dark fermentation of cane molasses are succinic acid and biohydrogen, with both having valuable applications in different industries. However, the continuous dark fermentation of cane molasses is a process regulated by many operational conditions, like reactor temperature and hydraulic retention time. It is important to control these conditions to shift metabolic pathways in order to increase production rates and yields. Thus, this research evaluates the response of mesophilic and thermophilic dark fermentation of cane molasses by mixed culture on hydrogen and succinic acid generation in fluidized bed reactors by changing the hydraulic retention time (8, 6, 4, 2, and 1 hour). In the thermophilic reactor (55°C), higher hydraulic retention times (from 8 to 4 hours) favored the succinate production (molar fractions between 75.0% and 81.4%). Similarly, in the mesophilic reactor (30°C), the molar fractions of succinate were 45.5% at the hydraulic retention time of 8 hours and 74.7% at 6 hours. The reduction of the hydraulic retention time to 1 hour decreased the succinic acid concentration to undetectable values and increased the hydrogen yield in both reactors. The lower hydraulic retention time also enhanced the hydrogen productivity to 171.1 mL/Lbed·h in the mesophilic reactor and to 303.4 mL/Lbed·h in the thermophilic reactor. These values were coincident with the predominant production of butyric and acetic acids. All of these points to the fact that the hydraulic retention time is an efficient parameter to control and select the production of hydrogen or succinic acid by mixed cultures under different temperatures. 相似文献
100.
Willian Tsuyoshi Kume Eslaine Patrícia de Jesus Porto Elaine Cristina de Lara Spada Douglas Ramalho Lisboa Fernando Ferrari Frutuoso Stachack Ailton José Terezo Thaís Hernandes Katiuchia Pereira Takeuchi Maísa Pavani dos Santos Elias Bibiana Mozzaquatro Gai Nair Honda Kawashita Suélem Aparecida de França Lemes 《Journal of Food Biochemistry》2021,45(8):e13834