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71.
Aida Ortega-Alonso Camilla Stephens M. Isabel Lucena Raúl J. Andrade 《International journal of molecular sciences》2016,17(5)
Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals and dietary supplements) presents with a range of both phenotypes and severity, from acute hepatitis indistinguishable of viral hepatitis to autoimmune syndromes, steatosis or rare chronic vascular syndromes, and from asymptomatic liver test abnormalities to acute liver failure. DILI pathogenesis is complex, depending on the interaction of drug physicochemical properties and host factors. The awareness of risk factors for DILI is arising from the analysis of large databases of DILI cases included in Registries and Consortia networks around the world. These networks are also enabling in-depth phenotyping with the identification of predictors for severe outcome, including acute liver failure and mortality/liver transplantation. Genome wide association studies taking advantage of these large cohorts have identified several alleles from the major histocompatibility complex system indicating a fundamental role of the adaptive immune system in DILI pathogenesis. Correct case definition and characterization is crucial for appropriate phenotyping, which in turn will strengthen sample collection for genotypic and future biomarkers studies. 相似文献
72.
73.
Vatnehol Svein Are Sirirud Hol Per Kristian Bjørnerud Atle Amiry-Moghaddam Mahmood Haglerød Camilla Storås Tryggve Holck 《Magma (New York, N.Y.)》2019,32(3):359-368
Magnetic Resonance Materials in Physics, Biology and Medicine - To investigate the effects of a range of parameter settings on T1 measurement stability in the portal vein using the T1-mapping... 相似文献
74.
Camilla Pedersen Kenny Erleben Jon Sporring 《Simulation Modelling Practice and Theory》2006,14(8):1135
Animating physically realistic human characters is challenging, since human observers are highly tuned to recognize human cues such as emotion and gender from motion patterns. The main contribution of this paper is a new model firmly based on biomechanics, which is used to animate balance and basic movements of a ballet dancers. It is supported by computer simulated experiments and it is in good agreement with biomechanical measurements of real-life dancers. Our results questions the previous approaches in dynamic animation, which only uses the center of gravity strategy, and instead demonstrate the viability of the center of pressure strategy. 相似文献
75.
Helm PA Diamond ML Semkin R Strachan WM Teixeira C Gregor D 《Environmental science & technology》2002,36(5):996-1003
Data collected over a 3-year study of a high arctic watershed and lake are used to understand the fate of organochlorine compounds (OCs) and form the basis of a mass balance contaminant fate model. The model uses the fugacity/aquivalence approach to describe OC dynamics between air, stream inflows and outflow, the water column, and surficial sediments. The steady-state model results indicate that stream inflows contributed from 96 to >99% of total chemical loadings, but 57-98% of total loadings were lost from the lake via the outlet, the percentage of which is controlled by the hydrologic regime of the high arctic lake. Conversely, only 0.4-3.4% of loadings were retained within the sediments due to the high export rate, minimal scavenging from the water column and low organic carbon fraction of the sediments. Using the unsteady-state model, which includes year-round processes, degradation was estimated to account for losses of 7-32% for the more persistent OCs and 42-50% for the less persistent OCs (alpha-HCH, gamma-HCH, and endosulfan I). If loadings were eliminated, water column concentrations would decline with half-lives <1 year for less persistent OCs and 1-2 years for the more persistent OCs, whereas the half-lives for OCs in sediment are 8-25 years. 相似文献
76.
“You know your own fistula,it becomes a part of you”—Patient perspectives on vascular access: A semistructured interview study 下载免费PDF全文
77.
Silvia Carlotto Ilaria Fortunati Camilla Ferrante Petra Schwille Antonino Polimeno 《Microfluidics and nanofluidics》2011,10(3):551-561
In this study, we explore and model the behavior of a prototype microfluidic device which employs two non-mixing fluids (sheath
and inlet fluids) displaying an asymmetric focused flow, in the presence of a fluorescent dye. Fluorescence correlation spectroscopy
is employed, allowing the precise measure of flow speeds across the channels and of the concentration profile of the central
focused flux along the flow direction. The system is modeled via a standard Navier–Stokes finite-element approach, coupled
to convection–diffusion equations for the solute. Simulations reproduce accurately the shape, the position, and the width
of the velocity and concentration profiles along the central channel and across the transversal and vertical sections of the
microfluidic device. The observed asymmetric flow with respect to the center of the channel is reproduced numerically with
an error in the position determination smaller than 1%. 相似文献
78.
Camilla Rotander 《Progress in Nuclear Energy》2003,43(1-4):275-280
The aim of this work is to investigate whether it is possible to extract information from process noise measurements by combining physical knowledge with system identification methods. This could be used for implicit measurements of process variables, tuning the model in a multidimensional parameter space, or simply for increasing our knowledge of the dynamical process, for example BWR stability. 相似文献
79.
Leopoldo Bertossi Camilla Schwind 《Annals of Mathematics and Artificial Intelligence》2004,40(1-2):5-35
In this article, we characterize in terms of analytic tableaux the repairs of inconsistent relational databases, that is databases that do not satisfy a given set of integrity constraints. For this purpose we provide closing and opening criteria for branches in tableaux that are built for database instances and their integrity constraints. We use the tableaux based characterization as a basis for consistent query answering, that is for retrieving from the database answers to queries that are consistent with respect to the integrity constraints. 相似文献
80.
Ilaria Rosso Camilla Galletti Sabina Fiorot Guido Saracco Edoardo Garrone Vito Specchia 《Journal of Porous Materials》2007,14(3):245-250
Even traces of CO in the hydrogen-rich gas fed to proton exchange membrane fuel cells (PEMFC) poison the platinum anode electrode
and dramatically decrease the cell power output. In this work, several 1%Pt catalysts, all on 3A-type zeolite support, were
prepared starting from different precursors and employing different methods: cation exchange (CE), wet impregnation (WI) and
incipient wetness impregnation (IWI). The catalysts were characterised in terms of platinum dispersion and tested under realistic
conditions in the quest of a catalyst for the removal of CO via the CO preferential oxidation (CO-PROX) reaction. The best
catalytic performance was shown by the 1%Pt–3A catalyst prepared by IWI starting from Pt(NH3)4Cl2 as a precursor, thanks to its highest platinum dispersion. 相似文献