Emotional expression and physical heath: Revising traumatic memories or fostering self-regulation?

Health benefits derived from personal trauma disclosure are well established. This study examined whether disclosing emotions generated by imaginative immersion in a novel traumatic event would similarly enhance health and adjustment. College women, preselected for trauma presence, were randomly assigned to write about real traumas, imaginary traumas, or trivial events. Yoked real-trauma and imaginary-trauma participants wrote about real-trauma participants' experiences. Imaginary-trauma participants were significantly less depressed than real-trauma participants at immediate posttest, but they were similarly angry, fearful, and happy. Compared with control group participants, both trauma groups made significantly fewer illness visits at 1-month follow-up: however, real-trauma participants reported more fatigue and avoidance than did the other groups. Imaginary-trauma group effects could reflect catharsis, emotional regulation, or construction of resilient possible selves. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sexual Pavlovian conditioned approach behavior in male Japanese quail (Coturnix coturnix japonica).

In 3 studies, a localized visual stimulus presented immediately prior to access to a female conspecific stimulated approach behavior in male Japanese quail after several conditioning trials. Development of this conditioned approach behavior was observed with 2 types of signal lights, 10- and 30-sec signal durations, large and small experimental chambers, and with male Ss housed continually in the conditioning chambers or only placed in the chamber for brief daily sessions. Conditioning also resulted in shorter latencies to initiate copulation in males given access to a female following the signal light, in comparison with males that received access to a female unannounced by the light. Although some aspects of the conditioning experience were retained over a 6-wk interval, some loss of the behavior was also observed. The conditioned behavior also decreased with repeated extinction trials, during which the signal light was presented in the absence of access to a female conspecific. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social support for the bereaved: Recipients' and providers' perspectives on what is helpful.

Interviewed 40 people (mean age 44 yrs) who had lost a spouse and 54 people (mean age 42 yrs) who had lost a child in a motor vehicle accident 4–7 yrs earlier to gather information concerning support attempts from others that were helpful and unhelpful. Support attempts most frequently mentioned as helpful were contact with a similar other and opportunity to express feelings; those most frequently mentioned as unhelpful were giving advice and encouraging recovery. To understand better the unhelpful support attempts, comparisons were made with 100 control Ss' reports of what they would do or say to help a bereaved person. The possibility that unhelpful support attempts occur because people do not know what to say to bereaved persons seems implausible in view of the enlightened responses given by controls. The close correspondence between bereaved Ss' reports of how recovered they felt and control respondents' estimates of how recovered the bereaved would be suggests that unhelpful support attempts are not based on misconceptions about recovery. These findings indicate that factors inherent in the transaction between the bereaved and potential supporters should be addressed in future research concerned with understanding support attempts that fail. (40 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Substructured formulations of nonlinear structure problems – influence of the interface condition

We investigate the use of non‐overlapping domain decomposition (DD) methods for nonlinear structure problems. The classic techniques would combine a global Newton solver with a linear DD solver for the tangent systems. We propose a framework where we can swap Newton and DD so that we solve independent nonlinear problems for each substructure and linear condensed interface problems. The objective is to decrease the number of communications between subdomains and to improve parallelism. Depending on the interface condition, we derive several formulations that are not equivalent, contrarily to the linear case. Primal, dual and mixed variants are described and assessed on a simple plasticity problem. Copyright © 2015 John Wiley & Sons, Ltd.     

Reusable knowledge in security requirements engineering: a systematic mapping study

Security is a concern that must be taken into consideration starting from the early stages of system development. Over the last two decades, researchers and engineers have developed a considerable number of methods for security requirements engineering. Some of them rely on the (re)use of security knowledge. Despite some existing surveys about security requirements engineering, there is not yet any reference for researchers and practitioners that presents in a systematic way the existing proposals, techniques, and tools related to security knowledge reuse in security requirements engineering. The aim of this paper is to fill this gap by looking into drawing a picture of the literature on knowledge and reuse in security requirements engineering. The questions we address are related to methods, techniques, modeling frameworks, and tools for and by reuse in security requirements engineering. We address these questions through a systematic mapping study. The mapping study was a literature review conducted with the goal of identifying, analyzing, and categorizing state-of-the-art research on our topic. This mapping study analyzes more than thirty approaches, covering 20 years of research in security requirements engineering. The contributions can be summarized as follows: (1) A framework was defined for analyzing and comparing the different proposals as well as categorizing future contributions related to knowledge reuse and security requirements engineering; (2) the different forms of knowledge representation and reuse were identified; and (3) previous surveys were updated. We conclude that most methods should introduce more reusable knowledge to manage security requirements.     

Pressure and Chemical Unfolding of an α-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1

When combined with NMR spectroscopy, high hydrostatic pressure is an alternative perturbation method used to destabilize globular proteins that has proven to be particularly well suited for exploring the unfolding energy landscape of small single-domain proteins. To date, investigations of the unfolding landscape of all-β or mixed-α/β protein scaffolds are well documented, whereas such data are lacking for all-α protein domains. Here we report the NMR study of the unfolding pathways of GIPC1-GH2, a small α-helical bundle domain made of four antiparallel α-helices. High-pressure perturbation was combined with NMR spectroscopy to unravel the unfolding landscape at three different temperatures. The results were compared to those obtained from classical chemical denaturation. Whatever the perturbation used, the loss of secondary and tertiary contacts within the protein scaffold is almost simultaneous. The unfolding transition appeared very cooperative when using high pressure at high temperature, as was the case for chemical denaturation, whereas it was found more progressive at low temperature, suggesting the existence of a complex folding pathway.     

Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice

Mucosal CD4⁺ T lymphocytes display a potent opioid-mediated analgesic activity in interleukin (IL)-10 knockout mouse model of inflammatory bowel diseases (IBD). Considering that endogenous opioids may also exhibit anti-inflammatory activities in the periphery, we examined the consequences of a peripheral opioid receptor blockade by naloxone-methiodide, a general opioid receptor antagonist unable to cross the blood–brain barrier, on the development of piroxicam-accelerated colitis in IL-10-deficient (IL-10^-/-) mice. Here, we show that IL-10-deficient mice treated with piroxicam exhibited significant alterations of the intestinal barrier function, including permeability, inflammation-related bioactive lipid mediators, and mucosal CD4⁺ T lymphocyte subsets. Opioid receptor antagonization in the periphery had virtually no effect on colitis severity but significantly worsened epithelial cell apoptosis and intestinal permeability. Thus, although the endogenous opioid tone is not sufficient to reduce the severity of colitis significantly, it substantially contributes to the protection of the physical integrity of the epithelial barrier.     

Cobalt Carbonyl‐Based Catalyst for Hydrosilylation of Carboxamides

The cobalt carbonyl [Co₂(CO)₈] complex is employed as a useful catalyst for the reduction of tertiary amides to the corresponding tertiary amines using 1,1,3,3‐tetramethyldisiloxane (TMDS) and poly(methylhydrosiloxane) (PMHS) as silane reagents under thermal (100 °C) or photo‐assisted conditions (UV, 350 nm at room temperature). Of particular interest, a low catalytic amount (0.5 mol%) of [Co₂(CO)₈] is used to perform the reaction with 2.2 equiv. of PMHS at 100 °C for 3 h. This reaction is the first example of a cobalt‐catalyzed hydrosilylation of amides.

     

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency,Peripheral Ligand Structure,and Topology with Cyclodextrin‐Based Iminosugar Click Clusters

In view of recent reports of a strong multivalent effect in glycosidase inhibition, a library of β‐CD‐based multivalent iminosugars has been efficiently synthesized by way of Cu^I‐catalyzed azide–alkyne cycloaddition (CuAAC). In combination with the first application of isothermal titration calorimetry (ITC) experiments to the study of multivalent iminosugar–enzyme interactions, the inhibition properties of these click clusters were evaluated on a panel of glycosidases. The structural parameters that were varied include valency, peripheral ligand structure, and topology. The inhibition results obtained with the iminosugar clusters further highlight the importance of multivalency in the inhibition of α‐mannosidase. Generally, the evaluated multivalent iminosugars displayed comparable thermodynamic signatures of binding towards α‐mannosidase (Jack bean): that is, large negative enthalpies of complexation coupled with small entropies of either sign. In addition, the enthalpy–entropy compensation observed in all tested cases may be attributed to a common mechanism of dissociation for the enzyme–multivalent iminosugar interactions. The measured binding stoichiometries indicated that each iminosugar cluster interacts with no more than one protein molecule.     

A pilot scale study of reverse osmosis for the purification of condensate arising from distillery stillage concentration plant

Reverse osmosis (RO) is an interesting process to eliminate small organic solutes (carboxylic acids and alcohols) from distillery condensates before recycling them into the fermentation step. This work investigates the influence of transmembrane pressure, pH and volume reduction factor (VRF) on the efficiency of reverse osmosis treatment of condensate from distillery stillage concentration at pilot scale using three pre-selected membranes (CPA2 and ESPA2 from Hydranautics, BW30 from DOW). Performances were assessed according to permeate flux, solutes rejection and abatement of fermentation inhibition. Transmembrane pressure increase leads to an increase of these three parameters with a plateau for rejections and abatement at 20 bar; however, in order to comply with membranes manufacturer's recommendations and to limit or delay polarization and fouling, it was decided to keep the permeate flux below a value of 30 L h⁻¹ m⁻². This corresponded to a maximum pressure of 10 bar for CPA2 and ESPA2 membranes and 25 bar for BW30 membrane. pH increase leads to a diminution of permeate flux and an increase of carboxylic acids rejection whatever the membrane; nevertheless, no abatement of fermentation inhibition is observed. Increasing VRF provokes a decrease of the permeate flux. Although local rejections are stable, the mean rejection assessed with the raw condensate (feed) and the mean permeate decreases. However, the fermentation inhibition remains under 10% up to a VRF of 8. BW30 membrane exhibits the highest rejections and inhibition abatement. On the basis of the pilot scale results with the BW30 membrane, a preliminary estimation of the membrane area is proposed for an industrial plant with 100 m³ h⁻¹ of condensate flow rate and the optimized parameters (pressure 25 bar, no pH modification, VRF 4 and 8).