全文获取类型
收费全文 | 99篇 |
免费 | 1篇 |
专业分类
化学工业 | 29篇 |
建筑科学 | 6篇 |
轻工业 | 6篇 |
无线电 | 12篇 |
一般工业技术 | 5篇 |
冶金工业 | 28篇 |
自动化技术 | 14篇 |
出版年
2022年 | 8篇 |
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 5篇 |
2012年 | 2篇 |
2011年 | 4篇 |
2010年 | 3篇 |
2009年 | 7篇 |
2008年 | 3篇 |
2007年 | 1篇 |
2006年 | 5篇 |
2005年 | 3篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 10篇 |
1997年 | 9篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1984年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有100条查询结果,搜索用时 15 毫秒
91.
Hai-Bin MA Wei-Dong ZHUO Davide LAVORATO Camillo NUTI Gabriele FIORENTINO Giuseppe Carlo MARANO Rita GRECO Bruno BRISEGHELLA 《Frontiers of Structural and Civil Engineering》2019,13(6):1510
Performance-based seismic design can generate predictable structure damage result with given seismic hazard. However, there are multiple sources of uncertainties in the seismic design process that can affect desired performance predictability. This paper mainly focuses on the effects of near-fault pulse-like ground motions and the uncertainties in bridge modeling on the seismic demands of regular continuous highway bridges. By modeling a regular continuous bridge with OpenSees software, a series of nonlinear dynamic time-history analysis of the bridge at three different site conditions under near-fault pulse-like ground motions are carried out. The relationships between different Intensity Measure (IM) parameters and the Engineering Demand Parameter (EDP) are discussed. After selecting the peak ground acceleration as the most correlated IM parameter and the drift ratio of the bridge column as the EDP parameter, a probabilistic seismic demand model is developed for near-fault earthquake ground motions for 3 different site conditions. On this basis, the uncertainty analysis is conducted with the key sources of uncertainty during the finite element modeling. All the results are quantified by the “swing” base on the specific distribution range of each uncertainty parameter both in near-fault and far-fault cases. All the ground motions are selected from PEER database, while the bridge case study is a typical regular highway bridge designed in accordance with the Chinese Guidelines for Seismic Design of Highway Bridges. The results show that PGA is a proper IM parameter for setting up a linear probabilistic seismic demand model; damping ratio, pier diameter and concrete strength are the main uncertainty parameters during bridge modeling, which should be considered both in near-fault and far-fault ground motion cases. 相似文献
92.
93.
94.
In the cruise ship industry product development and production activities are really complex and must follow strict rules imposed by naval registries. Designers are frequently required to choose among several alternative solutions (e.g., materials, components, layouts, etc.). Because of time constraints, as a matter of fact, design decisions are made fast and in a reactive way, according to the particular case, without considering decisions made in the past and without using specific decision support tools. The final choice is often left to a single designer's experience, whose selection criteria are unknown and not formalised. As a consequence there is no shared knowledge justifying the reason why a design solution has been chosen and whether it is the best one. We developed and implemented in Fincantieri S.p.A. – a leading company in the cruise ship industry – an original decision support tool, based on value analysis, designers can use to document and formalise their choices. Value analysis is a well known structured method to increase product value and/or cut costs, thus supporting the selection of the most valuable solution by means of objective parameters. We demonstrate that the proposed tool can also facilitate reuse of the available knowledge base on decisional criteria, increase interactions between people (design staff, buyers, shipyard personnel, etc.) involved in different stages of different value analysis projects, and reduce decision time. 相似文献
95.
Mali H. Rosnes Carine Yvon Andrew Macdonell Chullikkattil P. Pradeep Camillo Sartorio De‐Liang Long Bruno Pignataro Leroy Cronin 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(13):2316-2324
Herein a library of hybrid Mn‐Anderson polyoxometalates anions are presented: 1 , [(MnMo6O18)((OCH2)3‐C‐(CH2)7CHCH2)2]3?; compound 2 , [(MnMo6O18)((OCH2)3C‐NHCH2C16H9)2]3?; compound 3 , [(MnMo6O18)((OCH2)3C‐(CH2)7CHCH2)1((OCH2)3C‐NHCH2C16H9)1]3?; compound 4 , [(MnMo6O18)((OCH2)3C‐NHC(O)CH2CHCH2)2]3? and compounds 5 – 9 , [(MnMo6O18)((OCH2)3C‐NHC(O)(CH2)xCH3)2]), where x = 4, 10, 12, 14, and 18 respectively. The compounds resulting from the cation exchange of the anions 1 – 9 to give TBA ( a ) and DMDOA ( b ) salts, and additionally for compounds 1 , 2 and 3 , tetraphenylphosphonium (PPh4) ( c ) salts, are explored at the air/water interface using scanning force microscopy, showing a range of architectures including hexagonal structures, nanofibers and other supramolecular forms. Additionally the solid‐state structures for compounds 1c , 2c , 4a , 6a , 9a , are presented for the first time and these investigations demonstrate the delicate interplay between the structure of the covalently derivatised hybrid organo‐clusters as well as the ion‐exchange cation types. 相似文献
96.
Nicola Antonio di Meo Davide Loizzo Savio Domenico Pandolfo Riccardo Autorino Matteo Ferro Camillo Porta Alessandro Stella Cinzia Bizzoca Leonardo Vincenti Felice Crocetto Octavian Sabin Tataru Monica Rutigliano Michele Battaglia Pasquale Ditonno Giuseppe Lucarelli 《International journal of molecular sciences》2022,23(8)
Metabolomic analysis has proven to be a useful tool in biomarker discovery and the molecular classification of cancers. In order to find new biomarkers, and to better understand its pathological behavior, bladder cancer also has been studied using a metabolomics approach. In this article, we review the literature on metabolomic studies of bladder cancer, focusing on the different available samples (urine, blood, tissue samples) used to perform the studies and their relative findings. Moreover, the multi-omic approach in bladder cancer research has found novel insights into its metabolic behavior, providing excellent start-points for new diagnostic and therapeutic strategies. Metabolomics data analysis can lead to the discovery of a “signature pathway” associated with the progression of bladder cancer; this aspect could be potentially valuable in predictions of clinical outcomes and the introduction of new treatments. However, further studies are needed to give stronger evidence and to make these tools feasible for use in clinical practice. 相似文献
97.
Maria Stefania Sinicropi Jessica Ceramella Domenico Iacopetta Alessia Catalano Annaluisa Mariconda Camillo Rosano Carmela Saturnino Hussein El-Kashef Pasquale Longo 《International journal of molecular sciences》2022,23(23)
Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities. 相似文献
98.
Maddalena Di Sanzo Flora Cozzolino Anna Martina Battaglia Ilenia Aversa Vittoria Monaco Alessandro Sacco Flavia Biamonte Camillo Palmieri Francesca Procopio Gianluca Santamaria Francesco Ortuso Piero Pucci Maria Monti Maria Concetta Faniello 《International journal of molecular sciences》2022,23(21)
The H Ferritin subunit (FTH1), as well as regulating the homeostasis of intracellular iron, is involved in complex pathways that might promote or inhibit carcinogenesis. This function may be mediated by its ability to interact with different molecules. To gain insight into the FTH1 interacting molecules, we analyzed its interactome in HEK293T cells. Fifty-one proteins have been identified, and among them, we focused our attention on a member of the peroxiredoxin family (PRDX6), an antioxidant enzyme that plays an important role in cell proliferation and in malignancy development. The FTH1/PRDX6 interaction was further supported by co-immunoprecipitation, in HEK293T and H460 cell lines and by means of computational methods. Next, we demonstrated that FTH1 could inhibit PRDX6-mediated proliferation and migration. Then, the results so far obtained suggested that the interaction between FTH1/PRDX6 in cancer cells might alter cell proliferation and migration, leading to a less invasive phenotype. 相似文献
99.
Camillo Porcaro Antonio Di Renzo Emanuele Tinelli Vincenzo Parisi Cherubino Di Lorenzo Francesca Caramia Marco Fiorelli Giada Giuliani Ettore Cioffi Stefano Seri Vittorio Di Piero Francesco Pierelli Giorgio Di Lorenzo Gianluca Coppola 《International journal of molecular sciences》2022,23(21)
The role of the hypothalamus and the limbic system at the onset of a migraine attack has recently received significant interest. We analyzed diffusion tensor imaging (DTI) parameters of the entire hypothalamus and its subregions in 15 patients during a spontaneous migraine attack and in 20 control subjects. We also estimated the non-linear measure resting-state functional MRI BOLD signal’s complexity using Higuchi fractal dimension (FD) and correlated DTI/fMRI findings with patients’ clinical characteristics. In comparison with healthy controls, patients had significantly altered diffusivity metrics within the hypothalamus, mainly in posterior ROIs, and higher FD values in the salience network (SN). We observed a positive correlation of the hypothalamic axial diffusivity with migraine severity and FD of SN. DTI metrics of bilateral anterior hypothalamus positively correlated with the mean attack duration. Our results show plastic structural changes in the hypothalamus related to the attacks severity and the functional connectivity of the SN involved in the multidimensional neurocognitive processing of pain. Plastic changes to the hypothalamus may play a role in modulating the duration of the attack. 相似文献
100.
Dr. Matteo Lusardi Dr. Chiara Rotolo Dr. Marco Ponassi Dr. Erika Iervasi Dr. Camillo Rosano Prof. Andrea Spallarossa 《ChemMedChem》2022,17(5):e202100670
A series of highly functionalized pyrazole derivatives has been prepared by a one-pot, versatile and regioselective procedure. Pyrazoles 1 – 29 were tested in cell-based assay to assess their antiproliferative activity against a panel of tumour cells. Additionally, the cytotoxicity of prepared compounds was evaluated against normal human fibroblasts. The antiproliferative activity of the synthesized molecules emerged to be affected by the nature of the substituents of the pyrazole scaffold and derivatives 21 – 23 proved to inhibit the growth of melanoma and cervical cancer cells. Compound 23 was identified as the most active derivative and docking simulations predicted its ability to interact with estrogen receptors. 相似文献