Superfluid Helium Between Rotating Cylinders

The isotopic ordering of H2–D2 mixtures adsorbed at low temperature on graphite in the monolayer range is measured by small angle neutron scattering (SANS). We show that below 8 K, solid mixtures exhibit isotopic clustering at large density (monolayer completion) and a tendency towards the formation of ordered compounds for smaller density (near the commensurate structure).     

Crystallisation of high density polyethylene from dilute solution: Heterogeneous nucleation

The self-seeding crystallisation technique is applied to a dilute solution of polyethylene in xylene containing, in suspension, foreign particles; data concerning some pigments usually employed for colouring the plastics are reported. It is shown that this method allows easy demonstration of the interactions existing between the dissolved polymer and the pigment; at the same time, it is possible to study the morphology which is evolved as a consequence of these interactions under particularly simple conditions as only a small amount of polymer crystallises on the pigment particles. The behaviour of several pigments is consistent with the results obtained by crystallising the bulk polyethylene coloured with the same pigments. Some unusual morphologies are made evident.     

Surface treatments and roughness properties of Ti-based biomaterials

Nowadays, the use of implanted devices is a well-acknowledged practice in the field of orthopaedic and dental surgery. Scientific research and clinical experience suggest that the successful exploitation of these devices mainly depends on osseointegration, considered as both anatomical congruency and load-bearing capacity. Indeed, the osseointegration process is influenced by a wide range of factors: anatomical location, implant size and design, surgical procedure, loading effects, biological fluids, age and sex, and, in particular, surface characteristics. For this reason, several attempts have been aimed at modifying implant surface composition and morphology to optimise implant-to-bone contact and improve integration. Preliminary interactions between implanted materials and biological environment are deemed to be governed by the surface properties; they control the amount and quality of cell adhesion on the surface and, consequently, cell/tissue growth. Thus, surface properties govern new bone tissue formation and implant osseointegration. This paper reviews the state of art in the field of physical, chemical and biochemical treatments commonly used on Ti-based biomaterials for the production of biomedical devices. In particular, roughness characteristics due to physical and chemical techniques are investigated; the development of biologically active surfaces by means of biochemical functionalisation is also considered.     

Saccharomyces sensu stricto: systematics, genetic diversity and evolution

Saccharomyces sensu stricto is a species complex that includes most of the yeast strains relevant in the fermentation industry as well as in basic science. The taxonomy of these yeasts has always been controversial, particularly at species level. Over the years, the grouping of Saccharomyces sensu stricto yeasts has undergone changes in accordance with the system employed in classifying yeast cultures. Names of species and single isolates have also undergone changes that have caused confusion for yeast scientists and fermentation technologists. Recent findings have demonstrated that Saccharomyces hayanus and S. pastorianus are not homogeneous and do not seem to be natural groups. The present work examines the current trends in systematics studies, evidences the importance and mechanism of genetic variation and explores the most recent evolutionary theories as a way to elucidate the mechanism of speciation and achieve a more natural grouping of Saccharomyces sensu stricto species.     

A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements

A cyclic CCK8 analogue, cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 (Dpr=L-2,3-diaminopropionic acid), has been designed on the basis of the NMR structure of the bimolecular complex between the N-terminal fragment of the CCK(A) receptor and its natural ligand CCK8. The conformational features of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 have been determined by NMR spectroscopy in aqueous solution and in water containing DPC-d(38) micelles (DPC=dodecylphosphocholine). The structure of the cyclic peptide in aqueous solution is found to be in a relaxed conformation, with the backbone and Dpr29 side chain atoms making a planar ring and the N-terminal tripeptide extending approximately along the plane of this ring. In DPC/water, the cyclic peptide adopts a "boat-shaped" conformation, which is more compact than that found in aqueous solution. The cyclic constraint between the Dpr29 side chain and the CCK8 carboxyl terminus (Lys34) introduces a restriction in the backbone conformational freedom. However, the interaction of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 with the micelles still plays an important role in the stabilisation of the bioactive conformation. A careful comparison of the NMR structure of the cyclic peptide in a DPC micelle aqueous solution with the structure of the rationally designed model underlines that the turn-like conformation in the Trp30-Met31 region is preserved, such that the Trp30 and Met31 side chains can adopt the proper spatial orientation to interact with the CCK(A) receptor. The binding properties of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 to the N-terminal receptor fragment have been investigated by fluorescence spectroscopy in a micellar environment. Estimates of the apparent dissociation constant, K(d), were in the range of 70-150 nM, with a mean value of 120+/-27 nM. Preliminary nuclear medicine studies on cell lines transfected with the CCK(A) receptor indicate that the sulfated-Tyr derivative of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 displaces the natural ligand with an IC(50) value of 15 microM.     

Amnestic mild cognitive impairment: Difference of memory profile in subjects who converted or did not convert to Alzheimer's disease.

Episodic long-term, short-term, and implicit memory were investigated in 79 elderly subjects who fulfilled criteria for the amnestic form of mild cognitive impairment (a-MCI; i.e., by having an idiopathic amnestic disorder with absence of impairment in cognitive areas other than memory and without confounding medical or psychiatric conditions) and who developed Alzheimer's disease (AD) after 2 years as well as in 111 subjects affected by a-MCI who did not develop dementia. Results document a memory profile in a-MCI subjects characterized by preserved short-term and implicit memory and extensive impairment of episodic long-term memory. In virtually all episodic memory indexes examined (learning, forgetting, recognition abilities), a-MCI subjects who converted to AD were more severely impaired than were subjects who did not become demented. This memory profile, which closely resembles that exhibited by amnestic patients with bilateral mesial-temporal lobe lesions, confirms a precocious phase in preclinical AD characterized by selective involvement of mesial-temporal areas and worsening of the memory impairment as atrophic changes progress in hippocampal structures. In this context of pervasive episodic memory impairment, tests assessing the free recall of verbal material following a delay interval demonstrated the greater sensitivity to memory deficits of a-MCI subjects who developed AD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Quasiparticle correction for electronic transport in molecular wires

In this paper we present calculations of ballistic transport in molecular wires. The calculations are performed using an approximated version of the GW correction in the plasmon-pole framework, which is used to improve the starting Density Functional Theory energy spectrum of the molecule between metallic leads. We show that this correction reduces the error of the correlation part for the electron energy. Finally a model with complex bands is implemented in order to get the damping regime for long polymers.     

Thermal patterns in evaporating liquid

In this paper, some of the preparatory experiments of the ESA sponsored space program CIMEX-1 are presented. A liquid layer of variable thickness is subject to a flow of inert gas. The non-uniform evaporation induced by the gas flow creates a temperature gradient parallel to the interface triggering in that way thermocapillary convection. The combined action of evaporation, thermocapillarity and gravity has been not completely clarified both theoretically and experimentally. The experiment presented in this work concerns a liquid layer of ethanol of 2.2 mm thickness in presence of a mass flow of Nitrogen whose intensity varies in the range of hundreds of milliliter per minute. The experiments were performed at an initial liquid temperature of 21°C. The patterns observed are strongly dependent on the flow rate of inert gas. A change in the instability patterns has been observed for a gas flow of about 1.7 l/min.