Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?

Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to improve the survival of transplanted fat graft. The regenerative potential of LF is attributed to the multipotent stem cells found in large quantity in adipose tissue. However, a growing body of pre-clinical evidence shows that adipocytes and adipose-derived stromal cells may have pro-tumorigenic potential. Despite no clear indication from clinical studies has demonstrated an increased risk of cancer recurrence upon LF, these observations challenge the oncologic safety of the procedure. This review aims to provide an updated overview of both the clinical and the pre-clinical indications to the suitability and safety of LF in breast oncological surgery. Cellular and molecular players in the crosstalk between adipose tissue and cancer are described, and heterogeneous contradictory results are discussed, highlighting that important issues still remain to be solved to get a clear understanding of LF safety in breast cancer patients.     

Enantiodifferentiation of solerol isomers in dried figs and dates

Concentrates of dried fig (Ficus carica L.) and dried date (Phoenix dactylifera L.) fruits were obtained by solvent extraction (pentane: dichloromethane, 2∶1 by vol) and subsequently analysed by HRGC-MS. Using multidimensional gas chromatography (DB-Wax/oktakis2, 6-di-O-methyl-3-O-pentyl-γ-cyclodextrin) simultaneous enantiodifferentiation of 4,5-dihydroxyhexanoic acid-γ-lactone isomers (solerol) was carried out. The presence of this constituent is reported for the first time in figs and dates. Enantiomeric excesses of 80% and 90% were determined for the (4R,5R)-isomer in figs and dates, respectively.     

Regulating the geological sequestration of CO2

Governments worldwide should provide incentives for initial large-scale GS projects to help build the knowledge base for a mature, internationally harmonized GS regulatory framework. Health, safety, and environmental risks of these early projects can be managed through modifications of existing regulations in the EU, Australia, Canada, and the U.S. An institutional mechanism, such as the proposed Federal Carbon Sequestration Commission in the U.S., should gather data from these early projects and combine them with factors such as GS industrial organization and climate regime requirements to create an efficient and adaptive regulatory framework suited to large-scale deployment. Mechanisms to structure long-term liability and fund long-term postclosure care must be developed, most likely at the national level, to equitably balance the risks and benefits of this important climate change mitigation technology. We need to do this right. During the initial field experiences, a single major accident, resulting from inadequate regulatory oversight, anywhere in the world, could seriously endanger the future viability of GS. That, in turn, could make it next to impossible to achieve the needed dramatic global reductions in CO2 emissions over the next several decades. We also need to do it quickly. Emissions are going up, the climate is changing, and impacts are growing. The need for safe and effective CO2 capture with deep GS is urgent.     

EUE (energy use efficiency) of cropping systems for a sustainable agriculture

Energy efficiency of agriculture needs improvement to reduce the dependency on non-renewable energy sources. We estimated the energy flows of a wheat-maize-soybean-maize rotation of three different cropping systems: (i) low-input integrated farming (LI), (ii) integrated farming following European Regulations (IFS), and (iii) conventional farming (CONV). Balancing N fertilization with actual crop requirements and adopting minimum tillage proved the most efficient techniques to reduce energy inputs, contributing 64.7% and 11.2% respectively to the total reduction. Large differences among crops in energy efficiency (maize: 2.2 MJ kg⁻¹ grain; wheat: 2.6 MJ kg⁻¹ grain; soybean: 4.1 MJ kg⁻¹ grain) suggest that crop rotation and crop management can be equally important in determining cropping system energy efficiency. Integrated farming techniques improved energy efficiency by reducing energy inputs without affecting energy outputs. Compared with CONV, energy use efficiency increased 31.4% and 32.7% in IFS and LI, respectively, while obtaining similar net energy values. Including SOM evolution in the energy analysis greatly enhanced the energy performance of IFS and, even more dramatically, LI compared to CONV. Improved energy efficiency suggests the adoption of alternative farming systems to reduce greenhouse gas emissions from agriculture. However, a thorough evaluation should include net global warming potential assessment.     

High-temperature corrosion of pure chromium in SO2 (700–1000°C)

The corrosion of chromium under 1 atm of pure SO₂ has been studied over the range 700–1000°C at 100°C intervals. The reaction rate is higher than in pure oxygen and the scale does not contain sulfides, but only a small concentration of sulfur, in contrast with the behavior of other transition metals, even though the thermodynamic conditions are similar. Possible causes for this peculiar behavior are examined and discussed with reference to the results of the corrosion of chromium in pure oxygen.     

Comparative analysis of the outdoor performance of a dye solar cell mini‐panel for building integrated photovoltaics applications

New generation photovoltaic (PV) devices such as polymer and dye sensitized solar cells (DSC) have now reached a more mature stage of development, and among their various applications, building integrated PVs seems to have the most promising future, especially for DSC devices. This new generation technology has attracted an increasing interest because of its low cost due to the use of cheap printable materials and simple manufacturing techniques, easy production, and relatively high efficiency. As for the more consolidated PV technologies, DSCs need to be tested in real operating conditions and their performance compared with other PV technologies to put into evidence the real potential. This work presents the results of a 3 months outdoor monitoring activity performed on a DSC mini‐panel made by the Dyepower Consortium, positioned on a south oriented vertical plane together with a double junction amorphous silicon (a‐Si) device and a multi‐crystalline silicon (m‐Si) device at the ESTER station of the University of Rome Tor Vergata. Good performance of the DSC mini‐panel has been observed for this particular configuration, where the DSC energy production compares favorably with that of a‐Si and m‐Si especially at high solar angles of incidence confirming the suitability of this technology for the integration into building facades. This assumption is confirmed by the energy produced per nominal watt‐peak for the duration of the measurement campaign by the DSC that is 12% higher than that by a‐Si and only 3% lower than that by m‐Si for these operating conditions. Copyright © 2013 John Wiley & Sons, Ltd.     

Optimized Implementation of RNS FIR Filters Based on FPGAs

In this paper optimized Residue Number System (RNS) arithmetic blocks to better exploit some of the architectural characteristics of the last generation FPGAs are presented. The implementation of modulo m adders, modulo m constant and general multipliers, input and output converters are presented. These architectures are based on moduli sets chosen in order to optimally use the 6-input Look-Up Tables (LUTs) available in the Complex Logic Blocks (CLBs) of the new generation FPGAs. Experiments based on the implementation of Finite Impulse Response (FIR) filters characterized by different number of taps and wordlengths shows that the use of RNS together with suitable moduli sets optimally fits the 6-input LUTs in the last generation FPGAs architectures.     

Alkali-free glass as a high energy density dielectric material

One of the greatest challenges in the development of new high energy density materials is to increase dielectric permittivity while maintaining high breakdown strength. The dielectric breakdown behavior of an alkali-free barium boroaluminosilicate glass is shown to have remarkably high DC dielectric breakdown strength (12 MV/cm) and reasonably high permittivity (~ 6), equating to energy densities in excess of 35 J/cm³. This behavior is attributed to highly polarizable Ba ions enhancing the real part of complex permittivity, the low loss due to the alkali-free composition, and the substantially defect-free quality of the glass and its surfaces. To our knowledge, this is the highest breakdown strength reported for a bulk glass, and rivals the breakdown strength more typically observed in pristine thin films of SiO₂. These findings indicate that alkali-free multicomponent glasses may be strong candidates for next-generation high energy density storage capacitors for portable or pulsed power applications.