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971.
972.
Ana Carolina Mosca Fred van de Velde Johannes H.F. Bult Martinus A.J.S. van Boekel Markus Stieger 《Food quality and preference》2010,21(7):837-842
Model systems consisting of layers of mixed agar/gelatin gel were used to investigate the effect of the spatial distribution of sucrose on perceived sweetness intensity. 2-Alternative forced choice tests were performed with consumers to compare the sweetness of layered samples with an inhomogeneous distribution of sucrose to the sweetness of a reference sample with a homogeneous distribution. All samples had the same overall sucrose concentration (10%) and similar mechanical and rheological properties. Inhomogeneous samples that had large concentration gradients of sucrose between layers were perceived sweeter than the homogeneous reference. No differences in sweetness were observed between the reference and samples with small concentration gradients of sucrose. Additionally, the position of the layers containing sucrose did not affect sweetness. Results showed that an inhomogeneous distribution of sucrose can be used to reduce sucrose content by 20% without a decrease in sweetness intensity. 相似文献
973.
974.
Hana Kokot Boštjan Kokot Aleksandar Sebastijanović Carola Voss Rok Podlipec Patrycja Zawilska Trine Berthing Carolina Ballester-López Pernille Høgh Danielsen Claudia Contini Mikhail Ivanov Ana Krišelj Petra Čotar Qiaoxia Zhou Jessica Ponti Vadim Zhernovkov Matthew Schneemilch Zahra Doumandji Mojca Pušnik Polona Umek Stane Pajk Olivier Joubert Otmar Schmid Iztok Urbančič Martin Irmler Johannes Beckers Vladimir Lobaskin Sabina Halappanavar Nick Quirke Alexander P. Lyubartsev Ulla Vogel Tilen Koklič Tobias Stoeger Janez Štrancar 《Advanced materials (Deerfield Beach, Fla.)》2020,32(47):2003913
On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives. 相似文献
975.
Carolina Paganini Umberto Capasso Palmiero Sabrina Picciotto Alessandro Molinelli Ilaria Porello Giorgia Adamo Mauro Manno Antonella Bongiovanni Paolo Arosio 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(1):2204736
Programmable coacervates based on zwitterionic polymers are designed as dynamic materials for ion exchange bioseparation. These coacervates are proposed as promising materials for the purification of soft nanoparticles such as liposomes and extracellular vesicles (EVs). It is shown that the stimulus-responsiveness of the coacervates and the recruitment of desired molecules can be independently programmed by polymer design. Moreover, the polymeric coacervates can recruit and release intact liposomes, human EVs, and nanoalgosomes in high yields and separate vesicles from different types of impurities, including proteins and nucleic acids. This approach combines the speed and simplicity of precipitation methods and the programmability of chromatography with the gentleness of aqueous two-phase separation, thereby guaranteeing product stability. This material represents a promising alternative for providing a low-shear, gentle, and selective purification method for EVs. 相似文献
976.
977.
Lugmayr Artur Sutinen Erkki Suhonen Jarkko Sedano Carolina Islas Hlavacs Helmut Montero Calkin Suero 《Multimedia Tools and Applications》2017,76(14):15707-15733
Multimedia Tools and Applications - In human culture, storytelling is a long-established tradition. The reasons people tell stories are manifold: to entertain, to transfer knowledge between... 相似文献
978.
Erika Rosas Nicolás Hidalgo Veronica Gil-Costa Carolina Bonacic Mauricio Marin Hermes Senger Luciana Arantes Cesar Marcondes Olivier Marin 《计算机科学技术学报》2016,31(2):326-349
Mobile ad-hoc communication is a demonstrated solution to mitigate the impact of infrastructure failures during large-scale disasters. A very complex issue in this domain is the design validation of software applications that support decision-making and communication during natural disasters. Such disasters are irreproducible, highly unpredictable, and impossible to scale down, and thus extensive assessments cannot be led in situ. In this context, simulation constitutes the best approach towards the testing of software solutions for natural disaster responses. The present survey reviews mobility models, ad-hoc network architectures, routing protocols and network simulators. Our aim is to provide guidelines for software developers with regards to the performance evaluation of their applications by means of simulation. 相似文献
979.
Cássio G. C. Coelho Carolina G. Abreu Rafael M. Ramos Aldo H. D. Mendes George Teodoro Célia G. Ralha 《Applied Intelligence》2016,45(3):904-922
This paper presents an agent-based simulator for environmental land change that includes efficient and parallel auto-tuning. This simulator extends the Multi-Agent System for Environmental simulation (MASE) by introducing rationality to agents using a mentalistic approach—the Belief-Desire-Intention (BDI) model—and is thus named MASE-BDI. Because the manual tuning of simulation parameters is an error-prone, labour and computing intensive task, an auto-tuning approach with efficient multi-objective optimization algorithms is also introduced. Further, parallelization techniques are employed to speed up the auto-tuning process by deploying it in parallel systems. The MASE-BDI is compared to the MASE using the Brazilian Cerrado biome case. The MASE-BDI reduces the simulation execution times by at least 82 × and slightly improves the simulation quality. The auto-tuning algorithms, by evaluating less than 0.00115 % of a search space with 6 million parameter combinations, are able to quickly tune the simulation model, regardless of the objective used. Moreover, the experimental results show that executing the tuning in parallel leads to speedups of approximately 11 × compared to sequential execution in a hardware setting with 16-CPU cores. 相似文献
980.
In cold climate regions winter conditions significantly influence the performance of stormwater infiltration devices. Frozen soil and water storage by snow changes their operation. In this paper winter operation of a grassed infiltration swale was investigated using on-site and laboratory measurements. The field investigation of a grassed swale at a parking place in an Alpine region showed that the swale fulfilled its function properly. Although the top layer was frozen for some time, the storage capacity of the swale was sufficient to store the precipitation until the conditions improved. The soil attenuated the air temperature, at 20 cm below ground surface the soil was only frozen for one week. winter maintenance proved to be a problem, together with the snow from the parking place a lot of gravel and fine particles were deposited at one end of the swale. This decreased the hydraulic conductivity at that point significantly. The laboratory tests with soil columns showed an increase of flow time through the soil column with decreasing soil moisture content. For soil temperatures below 0 degrees C the hydraulic conductivity was reduced for increasing initial soil moisture contents. All in all the hydraulic conductivity was best around 0 degrees C for all soil water contents. However, also at minus 5 degrees C the coefficient of hydraulic conductivity was always at least above 10(-6) m/s, thus within the range of tolerated hydraulic conductivity specified in the national guidelines. Nevertheless, the handling of the soil was found to have high influence on the results. The results indicate that in the Alpine region infiltration swales operate sufficiently under winter conditions although with decreased performance. 相似文献