Maskless writing of microfluidics: Rapid prototyping of 3D microfluidics using scratch on a polymer substrate

We present a new rapid prototyping method designed for simple fabrication of 3D microfluidics using a maskless direct writing technique on polymer substrates. The entire process is enabled by a commercial cutter plotter with 10 μm resolution precision and high speed. A CAD design of top and bottom microstructures is directly written on a polymer substrate using a cutter plotter after setting up the suitable force. The smallest channel width of 20 μm was obtained with the minimum force and 100 μm from the maximum. Also the written depth increased linearly with force from 30 to 130 μm. Several 3D microfluidic devices are demonstrated using a maskless writing technique. The entire fabrication process from CAD layout to a final 3D device can be completed in 30 min outside the clean room facilities.     

Why Computers Can’t Feel Pain

The most cursory examination of the history of artificial intelligence highlights numerous egregious claims of its researchers, especially in relation to a populist form of ‘strong’ computationalism which holds that any suitably programmed computer instantiates genuine conscious mental states purely in virtue of carrying out a specific series of computations. The argument presented herein is a simple development of that originally presented in Putnam’s (Representation & Reality, Bradford Books, Cambridge in 1988) monograph, “Representation & Reality”, which if correct, has important implications for turing machine functionalism and the prospect of ‘conscious’ machines. In the paper, instead of seeking to develop Putnam’s claim that, “everything implements every finite state automata”, I will try to establish the weaker result that, “everything implements the specific machine Q on a particular input set (x)”. Then, equating Q (x) to any putative AI program, I will show that conceding the ‘strong AI’ thesis for Q (crediting it with mental states and consciousness) opens the door to a vicious form of panpsychism whereby all open systems, (e.g. grass, rocks etc.), must instantiate conscious experience and hence that disembodied minds lurk everywhere.     

Feature representation and signal classification in fluorescencein-situ hybridization image analysis

Fast and accurate analysis of fluorescence in-situ hybridization images for signal counting will depend mainly upon two components: a classifier to discriminate between artifacts and valid signals of several fluorophores (colors), and well discriminating features to represent the signals. Our previous work (2001) has focused on the first component. To investigate the second component, we evaluate candidate feature sets by illustrating the probability density functions and scatter plots for the features. The analysis provides first insight into dependencies between features, indicates the relative importance of members of a feature set, and helps in identifying sources of potential classification errors. Class separability yielded by different feature subsets is evaluated using the accuracy of several neural network-based classification strategies, some of them hierarchical, as well as using a feature selection technique making use of a scatter criterion. Although applied to cytogenetics, the paper presents a comprehensive, unifying methodology of qualitative and quantitative evaluation of pattern feature representation essential for accurate image classification. This methodology is applicable to many other real-world pattern recognition problems     

Working in the office of "Real Soon Now"

The "Office of Real Soon Now" is an ongoing experiment to see what it's like to use large-screen projection as our only computer display. We say "Real Soon Now" to contrast our experiment with the "Office of the Future", a project at the University of North Carolina that's building a much more sophisticated, laboratory-based environment in which multiple projectors seamlessly blend to display on most of the office surfaces. Our systems aren't nearly that fancy. Our idea was to experiment with systems we could build and operate within days. In our "Real Soon Now" offices, we use large-screen projection instead of conventional monitors. We've been using these systems for more than a year, and we'll never go back.     

TreePlus: interactive exploration of networks with enhanced tree layouts

Despite extensive research, it is still difficult to produce effective interactive layouts for large graphs. Dense layout and occlusion make food Webs, ontologies and social networks difficult to understand and interact with. We propose a new interactive visual analytics component called TreePlus that is based on a tree-style layout. TreePlus reveals the missing graph structure with visualization and interaction while maintaining good readability. To support exploration of the local structure of the graph and gathering of information from the extensive reading of labels, we use a guiding metaphor of "plant a seed and watch it grow." It allows users to start with a node and expand the graph as needed, which complements the classic overview techniques that can be effective at (but often limited to) revealing clusters. We describe our design goals, describe the interface and report on a controlled user study with 28 participants comparing TreePlus with a traditional graph interface for six tasks. In general, the advantage of TreePlus over the traditional interface increased as the density of the displayed data increased. Participants also reported higher levels of confidence in their answers with TreePlus and most of them preferred TreePlus     

Fringe—A Java-based finite fringe analysis package

A package for analysing two-dimensional finite fringe interferograms is described. Through a combination of automatic and interactive routines, an interferogram can be processed to extract the phase shift imparted on the recording light by a transparent object. The package consists of routines to condition and pad the original image for Fourier transform analysis, to filter the image and obtain the phase, to unwrap the phase, and to remove the background phase ramp. A sample image recorded using holographic interferometry is successfully analysed.Program summaryProgram title: FRINGECatalogue identifier: AEMM_v1_0Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEMM_v1_0.htmlProgram obtainable from: CPC Program Library, Queen’s University, Belfast, N. IrelandLicensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.htmlNo. of lines in distributed program, including test data, etc.: 134006No. of bytes in distributed program, including test data, etc.: 4029801Distribution format: tar.gzProgramming language: Java.Computer: Personal Computers.Operating system: Mac OS X, Windows XP, Linux and any other system that can run Java Jar files.RAM: 1GB recommendedClassification: 18.Nature of problem: A standalone multi-platform program to perform analysis of finite fringe interferograms.Solution method: Fourier filtering approach with phase unwrapping and background subtraction.Restrictions: Designed to analyse square images.Running time: Interactive processing takes several minutes. Minimal cpu time.     

Experimental Investigation of Nonconventional Confinement for Concrete Using FRP

The present study investigates experimentally the behavior of concrete confined with fiber reinforced polymers (FRP) in the form of jackets which are applied according to a number of nonconventional techniques. First, the effectiveness of various jacketing configurations combined with anchors as a measure of increasing the strength and deformability of L-shaped columns is investigated. It is concluded that easy to install and low-cost anchors made of resin impregnated fibers properly placed at the reentrant corner of L-shaped columns enable excellent mobilization of confining stresses supplied by the FRP jackets. Next, a number of alternative confinement methods are investigated on concrete cylinders, aimed at quantifying the effectiveness of (1) unbonded jacketing, (2) spirally applied strips attached only at their ends, and (3) jacketing directly on concrete with mortar plastering. Although the study may be regarded as preliminary, it provides useful experimental support to a number of techniques which have the potential to open new horizons in the field of externally applied FRP for enhancing concrete confinement.     

Child-Related Disagreements, Verbal Aggression, and Children's Internalizing and Externalizing Behavior Problems.

Dual-income parents (N = 122 couples) with an oldest child 18-60 months of age completed the Child-Rearing Disagreements Scale (E. N. Jouriles et al., 1991), the Child Behavior Checklist (T. M. Achenbach & L. A. Rescorla, 2000), and the Verbal Aggression subscale of the Conflicts and Problem-Solving Scale (P. K. Kerig, 1996). Replicating the results of E. N. Jouriles et al. (1991) and extending these findings to daughters and fathers, the authors found links between child-related disagreements and parental ratings of child behavior problems in this low-risk sample. There were no links between fathers' reports of verbal aggression and child behavior problems. Among mothers, however, use of verbal aggression mediated the link between child-related disagreements and ratings of sons' internalizing problems. Verbal aggression did not moderate the link between child-related disagreements and child behavior problems for either mothers or for fathers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A model for teaching psychotherapy theory through an integrative structure.

This article discusses a model for teaching psychotherapy theory through an integrative structure from the start of graduate students' training. This model articulates an ordering structure for the reputed 400+ so-called "theories" of psychotherapy. The rationale for such a structure highlights one dimension among several--that is, the recognition that a vast majority of mental health practitioners describe their orientation as eclectic or integrative. Professionals in training are encouraged to use this structure as an organizing principle to create the underpinnings for future professional development. The structure informs all aspects of a graduate-level course, including its syllabus, the textbooks selected, the reader, learning objectives, and tools for learning outcome assessment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)