Reliability analysis of uncertain dynamical systems using correlated function expansion

Reliability analysis of uncertain dynamical systems is considered. The excitations are modeled as non-stationary Gaussian processes, whereas parametric uncertainties due to structural randomness are modeled as non-Gaussian random variables. The structural responses are, therefore, non-Gaussian processes. The limit state is formulated in terms of the extreme value distribution of the response process. Developing these extreme value statistics analytically is not straightforward, which makes failure probability estimations difficult. An alternative procedure is investigated for computing exceedance probabilities. Proposed approach involves generating a full functional operational model, which approximates the original limit surface. Once the approximate form of the original limit state is defined, the failure probability can be obtained by statistical simulation. Thus, the method can be integrated with commercial finite element software, which permits uncertainty analysis of large structures with complexities that include material and geometric nonlinear behavior.     

Twinning-induced sluggish evolution of texture during recrystallization in AISI 316L stainless steel after cold rolling

This paper deals with the evolution of texture in AISI 316L austenitic stainless steel during annealing after 95 pct cold rolling. After 95 pct cold rolling, the texture is mainly of the brass type {110}〈112〉, along with a scatter toward the S orientation {123}〈634〉 and Goss orientation {011}〈100〉. Weak evidence of Cu component is observed at this high deformation level. During annealing, recovery is observed before any detectable recrystallization. Recrystallization proceeds through nucleation of subgrain by twinning within the deformed matrix and, later, preferential growth of those to consume the deformed matrix. After recrystallization, the overall texture intensity was weak; however, there are some discernible texture components. There was no existence of the brass component at this stage. Major components are centered on Goss orientation and Cu component {112}〈111〉 as well as the BR component {236}〈385〉. Also, a few orientations come up after recrystallization (i.e., {142}〈2−11〉 and {012}〈221〉). With increase in annealing temperature, the textural evolution shows emergence of weak texture with another new component, {197}〈211〉. The evolution of texture was correlated with the deformation texture through twin chain reaction.     

Microstrip rectangular resonators on ferrimagnetic substrates

The resonant frequency, bandwidth, efficiency and resonant length of a rectangular microstrip resonator on a ferrimagnetic substrate are derived theoretically and are computed for a typical ferrite substrate. The computed values are compared with those of a similar microstrip antenna on a dielectric substrate.     

A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions

A mammalian two-hybrid system was developed for high-throughput screening of compounds that disrupt specific protein-protein interactions. The existing mammalian systems are unsatisfactory for drug screening due to nonregulated expression of interacting proteins. To construct a tightly regulated system, the tetracycline repressor was fused with the inhibitory KRAB domain as a suppressor. The binding of the suppressor to the tet operator entirely blocked expression of two interacting proteins. When both the inducer doxycycline and drugs were added to the culture, the reporter gene was either activated by interaction of the paired proteins with ineffective drugs or remained silent due to disruption of the protein interactions by the effective drugs. We demonstrate that interactions of the type I receptor for TGFbeta with FKBP12 and the epidermal growth factor receptor (EGFR) with p85 are effectively disrupted by FK506 and EGFR kinase inhibitor AG1478, respectively. The power of this system for drug screening was further demonstrated by rapid identification of inhibitors from a druglike library for the receptor kinases.     

Polarization-based compensation of astigmatism

One approach to aberration compensation of an imaging system is to introduce a suitable phase mask at the aperture plane of an imaging system. We utilize this principle for the compensation of astigmatism. A suitable polarization mask used on the aperture plane together with a polarizer-retarder combination at the input of the imaging system provides the compensating polarization-induced phase steps at different quadrants of the apertures masked by different polarizers. The aberrant phase can be considerably compensated by the proper choice of a polarization mask and suitable selection of the polarization parameters involved. The results presented here bear out our theoretical expectation.     

Effective periodic pattern mining in time series databases

The goal of analyzing a time series database is to find whether and how frequent a periodic pattern is repeated within the series. Periodic pattern mining is the problem that regards temporal regularity. However, most of the existing algorithms have a major limitation in mining interesting patterns of users interest, that is, they can mine patterns of specific length with all the events sequentially one after another in exact positions within this pattern. Though there are certain scenarios where a pattern can be flexible, that is, it may be interesting and can be mined by neglecting any number of unimportant events in between important events with variable length of the pattern. Moreover, existing algorithms can detect only specific type of periodicity in various time series databases and require the interaction from user to determine periodicity. In this paper, we have proposed an algorithm for the periodic pattern mining in time series databases which does not rely on the user for the period value or period type of the pattern and can detect all types of periodic patterns at the same time, indeed these flexibilities are missing in existing algorithms. The proposed algorithm facilitates the user to generate different kinds of patterns by skipping intermediate events in a time series database and find out the periodicity of the patterns within the database. It is an improvement over the generating pattern using suffix tree, because suffix tree based algorithms have weakness in this particular area of pattern generation. Comparing with the existing algorithms, the proposed algorithm improves generating different kinds of interesting patterns and detects whether the generated pattern is periodic or not. We have tested the performance of our algorithm on both synthetic and real life data from different domains and found a large number of interesting event sequences which were missing in existing algorithms and the proposed algorithm was efficient enough in generating and detecting periodicity of flexible patterns on both types of data.     

Evolution of microstructure and texture in an ultrafine-grained Al6082 alloy during severe plastic deformation

The evolution of microstructure and texture in Al6082 precipitation-hardened alloy during equal-channel angular pressing (ECAP) was studied. It was found that although the dislocation density and the subgrain size saturated after 1 pass, the size of grains bounded by high angle boundaries reached its minimum value only after 4 passes. Furthermore, the grain orientation distribution changes between 4 and 8 passes, indicating the development of grain boundary structure even after the saturation of the parameters of the microstructure. As a result of this evolution, the initial texture of the commercial alloy was diminished after 8 passes and the grain orientation distribution became to be close to random case.