Requirement of cysteine-rich repeats of the Fas receptor for binding by the Fas ligand

The Fas receptor is a member of a family of cell death receptors, including tumor necrosis factor receptor I (TNFR I), death receptor 3 and 4 (DR3 and DR4), and cytopathic avian receptor 1 (CAR1). The Fas receptor is composed of several discrete domains, including three cysteine-rich domains (CRDs), a transmembrane domain, and an intracellular domain responsible for transmitting an apoptotic signal. While the mechanism of Fas-mediated cell death has become elucidated, the requirements for Fas ligand binding to the receptor have not been fully defined. Using a series of chimeric Fc-receptor fusion proteins between the human Fas receptor and TNFR I, each cysteine-rich domain of Fas was found to be required for interaction with the Fas ligand. Interestingly, TNFR I CRD1 could partially substitute for the Fas CRD1. The importance of this domain was underscored by the analysis of a Fas extracellular mutation (C66R), which resulted in a complete loss of ligand binding. This mutation was cloned from a human patient suffering from Canale-Smith syndrome, which is characterized by autoimmunity resembling that observed in the lpr and lprcg mice. The localization of essential ligand binding domains in the Fas receptor correlated exactly with the ability of the Fas receptor fusion proteins to prevent cell death mediated by the Fas ligand.     

An extraction method to determine interconnect parasitic parameters

Interconnect parasitic parameters in integrated circuits have significant impact on circuit speed. An accurate monitoring of these parameters can help to improve interconnect performance during process development, provide information for circuit design, or give useful reference for circuit failure analysis. Existing extraction methods either are destructive (such as SEM measurement) or can determine only partial parasitic parameters (such as large capacitor measurement). In this paper, we present a new method for extracting interconnect parasitic parameters, which can simultaneously determine the interlayer and intralayer capacitances, line resistance, and effective line width. The method is based on two test patterns of the same structure with different dimensions. The structure consumes less wafer area than existing methods. The method shows good agreement with SEM measurement of dielectric thickness in both nonglobal planarized and chemical-mechanical polished processes, and gives accurate prediction of the process spread of a ring oscillator speed over a wafer     

CTS-26型超声探伤仪典型故障的分析与排除

在简要介绍CTS-26型超声探伤仪工作原理及组成的基础上。对其几种典型故障作了具体的分析和处理。     

气囊内模制作桥面板在华丰湾防洪工程中的应用

采用气囊作内模进行浇筑桥面板混凝土 ,加快了预制桥面板施工进度 ,确保工程施工质量 ,并降低了工程施工成本     

高能超声处理Al-1Si合金凝固组织分析

采用高能超声处理Al-1Si合金熔体,借助金相显微镜和电子探针进行组织分析,并测定合金的熔化潜热,分析了熔体中超声空化效应和声流效应影响凝固过程的机理。结果表明,试样晶粒平均尺寸由超声处理前的94μm减小到超声处理后的34μm;合金试样的熔化吸热量由263.90J/g降低为159.81J/g,在熔体中施加高能超声显著改善了合金成分的均匀性并细化了晶粒。     

铝带材冷轧机机前展平辊重叠量的探讨

目前国内大多数铝加工厂对铝带材冷轧机机前展平辊的作用缺乏足够的认识，甚至弃而不用。本文主要论述展平辊的作用及展平辊重叠量的计算方法。     

米糠浸出油厂糠粞分离的必要性及其工艺探讨

糠粞分离是米糠油制取的重要工序之一。从提高经济效益,保证正常生产,降低残油和溶耗3个方面阐述了糠粞分离的必要性。介绍了风选和筛选两种糠粞分离方法及各自的优缺点。并着重介绍了风力式糠粞分离系统的工艺设计及设计、安装、操作的关键点。     

军械调运方案优化算法的设计与仿真

军械调运问题的数学模型和手工算法过去已有研究,但是当问题较为复杂时,手工算法就要花费大量时间而且准确性也难以保证。针对这一缺陷,本文在已有的数学模型和手工算法的基础上,设计了一种可以用计算机实现的基于递归的算法来寻求军械紧急调运问题的最优方案,并使用面向对象的java语言将算法实现。     

时间分幅全息技术及其应用

本文介绍了一种对研究发动机燃烧过程有着重要应用价值的实验技术－时间分幅全息技术，本文就该技术中常常出现的重影问题做了重点研究，通过分析重影出现的根源，找到了一种消除重影的新方法，文章还举例说明了该技术在液体破碎机理问题保研究中的应用。