Brokering the customer-supplier partnership in product design and realization over the World Wide Web

This research is concerned with the application of the World Wide Web (WWW or web) technology to facilitate the early supplier involvement in new product development. The paper focuses on two parts of the resulting web-based system. The first part is the Bid Explorer underpinned by a bid model which is based on design specification. The bid model consists of inquiries which in turn have values of different types. Inquiries are represented in a hierarchical tree. The bid model is collaboratively established by, and thereafter commonly shared between, the customer and all the interested suppliers. From the point of view of the customer, the inquiries are their requirements. In contrast, from the supplier's viewpoint the inquiries are their capabilities. The second part of the system is the Partnership Explorer which is underpinned by a partnership model. This partnership model uses four types of numeric partnership indices, namely satisfaction index (SI), flexibility index (FI), risk index (RI), and confidence index (CI). The SI is based on the overlap between the customer requirements and supplier capabilities. The FI is based on the surplus of the supplier capabilities in relation to the customer requirements. The RI is evaluated through the shortage of the supplier capabilities with reference to the customer requirements. The CI is based on the past performance records of a supplier.     

A novel mitochondrial DNA point mutation associated with mitochondrial encephalocardiomyopathy

A novel mitochondrial DNA (mtDNA) mutation at position nt 4320 in the tRNA(Ile) gene was associated with severe encephalopathy in a 7-month-old infant, who died of intractable hypertrophic cardiomyopathy. The mutation was present in heteroplasmic fashion (88%) in muscle and fulfills accepted criteria for pathogenicity. This is the fourth pathogenic mutation identified in this gene, which appears to be a "hotspot" for deleterious mutations affecting the heart. This report adds to the evidence of genetic heterogeneity in hypertrophic cardiomyopathies.     

Immunohistological evidences of Ginkgo biloba extract altering Bax to Bcl-2 expression ratio in the hippocampus and motor cortex of senescence accelerated mice

Ginkgo biloba extract 761 appears to display neuroprotective effect in many nervous diseases and aging. Deterioration of mental functions during aging is always accompanied by loss of neurons, presumably through apoptosis. Here, we studied the effect of G. biloba extract in the expression of Bax/Bcl-2 ratio, an important apoptotic index, in the hippocampus and motor cortex of the aging brain. Bax and Bcl-2 expressions were examined with immunohistochemical methods. Senescence Accelerated Mice Prone Strain 8 was used because the aging process was accelerated with neuropathological alterations similar to those found in the aging human brain. The mice were fed with either G. biloba extract or sucrose from the age of 3 weeks until sacrifice at 3 or 9 months old. In the hippocampus of G. biloba fed 9-month-old mice, the ratio of Bax positive cell to Bcl-2 positive cell (Bax/Bcl-2 expression ratio) was 11.43 +/- 3.11 (mean +/- SD); significantly lower (P < 0.05) than the Bax/Bcl-2 expression ratio of 20.99 +/- 5.34 in the sucrose fed mice. The Bax/Bcl-2 expression cell ratios, however, in the motor cortex were not significantly different between the two groups (2.22 +/- 1.35 versus 2.27 +/- 2.02 for the G. biloba and the sucrose fed mice, respectively). The decrease in the Bax/Bcl-2 expression cell ratio following G. biloba treatment might hence be able to protect the aging hippocampus from moving further down the apoptotic pathway. Western blotting confirmed the decrease of Bax in the brain even after a short term and high dose Ginkgo treatment. It is speculated that the G. biloba extract may be a potential neuroprotective agent against apoptosis through the differential expressions of the Bax and Bcl-2 in the hippocampus.     

Economical, environmental and technical analysis of building integrated photovoltaic systems in Malaysia

Malaysia has identified photovoltaic systems as one of the most promising renewable sources. A great deal of efforts has been undertaken to promote the wide applications of PV systems. With the recent launch of a PV market induction programme known as SURIA 1000 in conjunction with other relevant activities undertaken under the national project of Malaysia Building Integrated Photovoltaic (MBIPV), the market of PV systems begins to be stimulated in the country. As a result, a wide range of technical, environmental and economic issues with regard to the connection of PV systems to local distribution networks becomes apparent. Numerous studies were therefore carried out in collaboration with Malaysian Energy Centre to address a number of those important issues. The findings of the studies are presented in the paper and can be served as supplementary information to parties who are directly and indirectly involved in the PV sector in Malaysia.     

A preliminary investigation of water usage behavior in single-family homes

As regional drought conditions continue deteriorating around the world, residential water use has been brought into the built environment spotlight. Nevertheless, the understanding of water use behavior in residential buildings is still limited. This paper presents data analytics and results from monitoring data of daily water use (DWU) in 50 single-family homes in Texas, USA. The results show the typical frequency distribution curve of the DWU per household and indicate personal income, education level and energy use of appliances all have statistically significant effects on the DWU per capita. Analysis of the water-intensive use demonstrates the residents tend to use more water in post-vacation days. These results help generate awareness of water use behavior in homes. Ultimately, this research could support policy makers to establish a water use baseline and inform water conservation programs.