Intracellularly Degradable Hydrogen‐Bonded Polymer Capsules

The assembly of low‐fouling polymer capsules with redox‐responsive behavior and intracellular degradability is reported. Thiol‐containing poly(2‐ethyl‐2‐oxazoline) (PEtOxMA_SH) brushes are synthesized by atom transfer radical polymerization (ATRP) of oligo(2‐ethyl‐2‐oxazoline)methacrylate and glycidyl methacrylate (GMA) and subsequent ring‐opening reaction of the GMA. Sequential deposition of PEtOxMA_SH/poly(methacrylic acid) (PMA) multilayers onto silica (SiO₂) particle templates and crosslinking through disulfide formation yield stable capsules after the removal of the SiO₂ templates by buffered hydrofluoric acid (HF). The redox‐responsive nature of the disulfide crosslinking groups enables the degradation of these capsules under simulated intracellular conditions at pH 5.9 and 5 mm glutathione (GSH). Furthermore, capsule degradation is observed after incubation with dendritic (JAWS II) cells. Even at high capsule‐to‐cell ratios, PEtOxMA_SH capsules show only negligible cytotoxicity. Quartz crystal microgravimetry (QCM) studies, using 100% human serum, reveal that films prepared from PEtOxMA_SH exhibit low‐fouling properties. The degradation and low‐fouling properties are promising for application of PEtOxMA_SH films/capsules for the delivery and triggered release of therapeutics.     

Hydrodynamically Guided Hierarchical Self‐Assembly of Peptide–Protein Bioinks

Effective integration of molecular self‐assembly and additive manufacturing would provide a technological leap in bioprinting. This article reports on a biofabrication system based on the hydrodynamically guided co‐assembly of peptide amphiphiles (PAs) with naturally occurring biomolecules and proteins to generate hierarchical constructs with tuneable molecular composition and structural control. The system takes advantage of droplet‐on‐demand inkjet printing to exploit interfacial fluid forces and guide molecular self‐assembly into aligned or disordered nanofibers, hydrogel structures of different geometries and sizes, surface topographies, and higher‐ordered constructs bound by molecular diffusion. PAs are designed to co‐assemble during printing in cell diluent conditions with a range of extracellular matrix (ECM) proteins and biomolecules including fibronectin, collagen, keratin, elastin‐like proteins, and hyaluronic acid. Using combinations of these molecules, NIH‐3T3 and adipose derived stem cells are bioprinted within complex structures while exhibiting high cell viability (>88%). By integrating self‐assembly with 3D‐bioprinting, the study introduces a novel biofabrication platform capable of encapsulating and spatially distributing multiple cell types within tuneable pericellular environments. In this way, the work demonstrates the potential of the approach to generate complex bioactive scaffolds for applications such as tissue engineering, in vitro models, and drug screening.     

Study of the breakdown failure mechanisms for power AlGaN/GaN HEMTs implemented using a RF compatible process

The breakdown failure mechanisms for a family of power AlGaN/GaN HEMTs were studied. These devices were fabricated using a commercially available MMIC/RF technology with a semi-insulating SiC substrate. After a 10 min thermal annealing at 425 K, the transistors were subjected to temperature dependent electrical characteristics measurement. Breakdown degradation with a negative temperature coefficient of ?0.113 V/K for the devices without field plate was found. The breakdown voltage is also found to be a decreasing function of the gate length. Gate current increases simultaneously with the drain current during the drain-voltage stress test. This suggests that the probability of a direct leakage current path from gate to the 2-DEG region. The leakage current is attributed by a combination of native and generated traps/defects dominated gate tunneling, and hot electrons injected from the gate to channel. Devices with field plate show an improvement in breakdown voltage from ～40 V (with no field plate) to 138 V and with lower negative temperature coefficient. A temperature coefficient of ?0.065 V/K was observed for devices with a field plate length of 1.6 μm.     

Efficient FPGA implementation of bit-stream multipliers

A four-input adder structure for the FPGA implementation of a sigma-delta bit-stream multiplier is proposed. Conventional bit-stream multiplier implementations involve two-input adder circuits. It is shown that the four-input adder structure is more resource-efficient (over 40% hardware savings) and faster (over 20% higher clock frequency) when implemented using state-of-the-art FPGA architecture featuring six-input look-up tables     

Theoretical design for 120 GHz semiconductor junction circulators: effects of different numbers of terms in the Green's function

A theoretical analysis of the predicted performance and field distributions for semiconductor junction circulators is based on Bosma's Green's function approach which involves a summation of infinite series in the mathematical derivation. The effects are considered of taking a different number of terms in the series, looking at three different circulators centred at 120 GHz. The narrowband semiconductor circulators show a similar effect to the ferrite junction circulator because the field distributions inside the semiconductor discs can be approximated by only considering the dominant modes. However, there is no dominant mode in the broadband circulator and the higher order modes play an important role in the operation of this circulator. In order to obtain a precise representation of the circulation effects inside both narrowband and broadband circulators, at least up to the 6th term, or 18 terms in all, are required to be added in the summation of Green's functions.     

CMOS retinal prosthesis with on-chip electrode impedance measurement

A retinal prosthesis device with built-in self-test capability is proposed and demonstrated. The measurement of electrode impedance as a self-test is achieved without increasing the chip area by employing analogue multiplexers to allow the electrodes to be used for both stimulation of retinal cells and measurement of impedance. Measurement is performed using a four-terminal method to ensure good accuracy. A prototype stimulus chip with 16/spl times/16 channels is fabricated using standard 0.6 /spl mu/m CMOS technology, and is demonstrated to provide self-test functionality with error of as little as 0.05% in the frequency range of 100 Hz to 100 kHz.     

Generalized multiuser orthogonal space-division multiplexing

This paper addresses the problem of performing orthogonal space-division multiplexing (OSDM) for downlink, point-to-multipoint communications when multiple antennas are utilized at the base station (BS) and (optionally) all mobile stations (MS). Based on a closed-form antenna weight solution for single-user multiple-input multiple-output communications in the presence of other receiver points, we devise an iterative algorithm that finds the multiuser antenna weights for OSDM in downlink or broadcast channels. Upon convergence, each mobile user will receive only the desired activated spatial modes with no cochannel interference. Necessary and sufficient conditions for the existence of OSDM among the number of mobile users, the number of transmit antennas at the BS, and the number of receive antennas at the MS, are also derived. The assumption for the proposed method is that the BS knows the channels for all MS's and that the channel dynamics are quasi-stationary.     

Numerical investigation of self-heating effects of oxide-confined vertical-cavity surface-emitting lasers

We present a comprehensive numerical model to simulate self-heating effects of oxide-confined vertical-cavity surface-emitting lasers (VCSELs) under continuous-wave operation. The model self-consistently accounts for the close interaction between optical, electrical, and thermal processes in VCSELs. In particular, hot carriers and nonequilibrium optical phonons in the quantum wells are modeled by solving a carrier energy balance equation and an optical phonon rate equation. Our numerical simulations reveal that they are responsible for aggravated thermal rollovers in VCSELs' L-I characteristics. Detailed comparisons are made and good agreement is obtained between simulations and experiments for the L-I-V and lasing wavelength characteristics of VCSELs with varying oxide aperture size. Various mechanisms that result in the L-I thermal rollover behavior are also investigated with the aid of simulations.     

Fast minimization methods for solving constrained total-variation superresolution image reconstruction

In this paper, we study the problem of reconstructing a high-resolution image from several decimated, blurred and noisy low-resolution versions of the high-resolution image. The problem can be formulated as a combination of the total variation (TV) inpainting model and the superresolution image reconstruction model. The main purpose of this paper is to develop an inexact alternating direction method for solving such constrained TV image reconstruction problem. Experimental results are given to show that the proposed algorithm is effective and efficient.