全文获取类型
收费全文 | 1191篇 |
免费 | 90篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 6篇 |
综合类 | 3篇 |
化学工业 | 590篇 |
金属工艺 | 7篇 |
机械仪表 | 21篇 |
建筑科学 | 29篇 |
能源动力 | 27篇 |
轻工业 | 154篇 |
水利工程 | 4篇 |
石油天然气 | 1篇 |
无线电 | 89篇 |
一般工业技术 | 174篇 |
冶金工业 | 50篇 |
原子能技术 | 1篇 |
自动化技术 | 126篇 |
出版年
2024年 | 2篇 |
2023年 | 21篇 |
2022年 | 177篇 |
2021年 | 178篇 |
2020年 | 40篇 |
2019年 | 39篇 |
2018年 | 47篇 |
2017年 | 29篇 |
2016年 | 53篇 |
2015年 | 43篇 |
2014年 | 52篇 |
2013年 | 76篇 |
2012年 | 61篇 |
2011年 | 90篇 |
2010年 | 52篇 |
2009年 | 39篇 |
2008年 | 39篇 |
2007年 | 38篇 |
2006年 | 29篇 |
2005年 | 28篇 |
2004年 | 23篇 |
2003年 | 14篇 |
2002年 | 10篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 7篇 |
1998年 | 11篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 9篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1983年 | 3篇 |
1981年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有1282条查询结果,搜索用时 15 毫秒
41.
Rosa Iacovino Filomena Rapuano Jolanda Valentina Caso Agostino Russo Margherita Lavorgna Chiara Russo Marina Isidori Luigi Russo Gaetano Malgieri Carla Isernia 《International journal of molecular sciences》2013,14(7):13022-13041
The aptitude of cyclodextrins (CDs) to form host-guest complexes has prompted an increase in the development of new drug formulations. In this study, the inclusion complexes of pipemidic acid (HPPA), a therapeutic agent for urinary tract infections, with native β-CD were prepared in solid state by kneading method and confirmed by FT-IR and 1H NMR. The inclusion complex formation was also characterized in aqueous solution at different pH via UV-Vis titration and phase solubility studies obtaining the stability constant. The 1:1 stoichiometry was established by a Job plot and the inclusion mechanism was clarified using docking experiments. Finally, the antibacterial activity of HPPA and its inclusion complex was tested on P. aeruginosa, E. coli and S. aureus to determine the respective EC50s and EC90s. The results showed that the antibacterial activity of HPPA:β-CD against E. coli and S. aureus is higher than that of HPPA. Furthermore, HPPA and HPPA:β-CD, tested on human hepatoblastoma HepG2 and MCF-7 cell lines by MTT assay, exhibited, for the first time, antitumor activities, and the complex revealed a higher activity than that of HPPA. The use of β-CD allows an increase in the aqueous solubility of the drug, its bioavailability and then its bioactivity. 相似文献
42.
The Alder ene functionalization reaction of double bonds containing macromolecules such as polyisobutene oligomer (PIB) and a styrene-butadiene-styrene triblock copolymer (SBS) samples with maleic anhydride (MAH) or diethyl maleate (DEM) as enophiles is described. The analysis of the products by means of different techniques assesses the addition of the polar molecules to the reactive vinylidene units of the polymer with functional degrees (FD) depending on the type of enophile and polymer reactivity. The role of the reaction conditions and the use as Lewis acids as catalysts are discussed in terms of their influence on the addition reaction extent and on the polymer molecular weight. 相似文献
43.
Maria Chiara Dalconi Giuseppe Cruciani Alberto Alberti Paolo Ciambelli 《Catalysis Today》2005,110(3-4):345-350
High-silica zeolites exchanged with transition metal ions (TMIs) are the subject of great interest for their unusual catalytic activity and selectivity. Structural information like coordination and accessibility of TMIs in zeolites are important factors for understanding their catalytic activity. Siting of TMIs in zeolites is typically obtained by spectroscopic (EXAFS, EPR, UV–vis and IR) and computational methods, as in the case of Co-ferrierite. However, some controversy exists in the literature concerning the model for incorporation of bare Co ions in ferrierite. We show here that the results of our synchrotron X-ray powder diffraction studies on Co- and Ni-exchanged ferrierite (Si/Al = 8.5) are in a good agreement with the model of Co siting based on an indirect spectroscopic approach and help to validate this model. By direct structural evidences, a possible explanation for the larger catalytic activity of Co sites in the main channels of ferrierite can be inferred. A combination of data from in situ XRD continuous monitoring of the Co ion migration during calcination and crystal-chemical considerations allows to device a strategy for the design of optimised co-cations containing Co-ferrierite catalysts. 相似文献
44.
45.
Maria Lucia Iacovino Chiara Carmen Miceli Marco De Felice Biagio Barone Luca Pompella Francesco Chiancone Erika Di Zazzo Giuseppe Tirino Carminia Maria Della Corte Ciro Imbimbo Ferdinando De Vita Felice Crocetto 《International journal of molecular sciences》2022,23(3)
Muscle invasive bladder cancer (MIBC) is a widespread malignancy with a worse prognosis often related to a late diagnosis. For early-stage MIBC pts, a multidisciplinary approach is mandatory to evaluate the timing of neoadjuvant chemotherapy (NAC) and surgery. The current standard therapy is platinum-based NAC (MVAC-methotrexate, vinblastine, doxorubicin, and cisplatin or Platinum–Gemcitabine regimens) followed by radical cystectomy (RC) with lymphadenectomy. However, preliminary data from Vesper trial highlighted that dose-dense NAC MVAC is endowed with a good pathological response but shows low tolerability. In the last few years, translational-based research approaches have identified several candidate biomarkers of NAC esponsiveness, such as ERCC2, ERBB2, or DNA damage response (DDR) gene alterations. Moreover, the recent consensus MIBC molecular classification identified six molecular subtypes, characterized by different sensitivity to chemo- or targeted or immunotherapy, that could open a novel procedure for patient selection and also for neoadjuvant therapies. The Italian PURE-01 phase II Trial extended data on efficacy and resistance to Immune Checkpoint Inhibitors (ICIs) in this setting. In this review, we summarize the most relevant literature data supporting NAC use in MIBC, focusing on novel therapeutic strategies such as immunotherapy, considering the better patient stratification and selection emerging from novel molecular classification. 相似文献
46.
Chiara Cipollina Andreina Bruno Salvatore Fasola Marta Cristaldi Bernardo Patella Rosalinda Inguanta Antonio Vilasi Giuseppe Aiello Stefania La Grutta Claudia Torino Elisabetta Pace 《International journal of molecular sciences》2022,23(3)
Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). Increased oxidative stress leads to exhaustion of antioxidant defenses, alterations in autophagy/mitophagy and cell survival regulatory mechanisms, thus promoting cell senescence. All these events are amplified by the increase of inflammation driven by oxidative stress. Several models of bronchial epithelial cells are used to study the molecular mechanisms and the cellular functions altered by cigarette smoke extract (CSE) exposure, and to test the efficacy of molecules with antioxidant properties. This review offers a comprehensive synthesis of human in-vitro and ex-vivo studies published from 2011 to 2021 describing the molecular and cellular mechanisms evoked by CSE exposure in bronchial epithelial cells, the most used experimental models and the mechanisms of action of cellular antioxidants systems as well as natural and synthetic antioxidant compounds. 相似文献
47.
Chiara Maria Motta Emanuela Califano Rosaria Scudiero Bice Avallone Chiara Fogliano Salvatore De Bonis Anja Raggio Palma Simoniello 《International journal of molecular sciences》2022,23(4)
In aquatic organisms, cadmium exposure occurs from ovum to death and the route of absorption is particularly wide, being represented by skin, gills and gastrointestinal tract, through which contaminated water and/or preys are ingested. It is known that cadmium interferes with the gut; however, less information is available on cadmium effects on an important component of the gut, namely goblet cells, specialized in mucus synthesis. In the present work, we studied the effects of two sublethal cadmium concentrations on the gut mucosa of Danio rerio. Particular attention was paid to changes in the distribution of glycan residues, and in metallothionein expression in intestinal cells. The results show that cadmium interferes with gut mucosa and goblet cells features. The effects are dose- and site-dependent, the anterior gut being more markedly affected than the midgut. Cadmium modifies the presence and/or distribution of glycans in the brush border and cytoplasm of enterocytes and in the goblet cells’ cytoplasm and alters the metallothionein expression and localization. The results suggest a significant interference of cadmium with mucosal efficiency, representing a health risk for the organism in direct contact with contamination and indirectly for the trophic chain. 相似文献
48.
Identification and Structure–Activity Relationship Studies of Small‐Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1 下载免费PDF全文
Dr. Dina Robaa Dr. Tobias Wagner Chiara Luise Dr. Luca Carlino Joel McMillan Dr. Ralf Flaig Prof. Dr. Roland Schüle Prof. Dr. Manfred Jung Prof. Dr. Wolfgang Sippl 《ChemMedChem》2016,11(20):2327-2338
The methyllysine reader protein Spindlin1 has been implicated in the tumorigenesis of several types of cancer and may be an attractive novel therapeutic target. Small‐molecule inhibitors of Spindlin1 should be valuable as chemical probes as well as potential new therapeutics. We applied an iterative virtual screening campaign, encompassing structure‐ and ligand‐based approaches, to identify potential Spindlin1 inhibitors from databases of commercially available compounds. Our in silico studies coupled with in vitro testing were successful in identifying novel Spindlin1 inhibitors. Several 4‐aminoquinazoline and quinazolinethione derivatives were among the active hit compounds, which indicated that these scaffolds represent promising lead structures for the development of Spindlin1 inhibitors. Subsequent lead optimization studies were hence carried out, and numerous derivatives of both lead scaffolds were synthesized. This resulted in the discovery of novel inhibitors of Spindlin1 and helped explore the structure–activity relationships of these inhibitor series. 相似文献
49.
Lucia Marsich Alessio Ferluga Norman Venturini Marco Caniato Orfeo Sbaizero Chiara Schmid 《Polymer Engineering and Science》2016,56(7):727-734
In the field of self‐reinforced composites many researchers have focused their attention on the coextruded tapes composed of polypropylene core and PP/PE copolymer skin. Two similar commercial fabrics (P and T) have been compared in respect of their peel resistance. For both materials, peel resistance has a periodic trend that regularly follows fabric weave style. T has demonstrated an average peel resistance and a well‐bonded area slightly greater than P. Skin/core interfacial properties have been investigated and a crosscheck between differential scanning calorimetry (DSC) and Raman spectroscopy has been adopted to understand the influence of skin structure on consolidated laminate. DSC curves exhibit three melting peaks during first heating for both fabrics, corresponding to copolymer, skin/core interface, and core melting. After consolidation at 140°C stretching‐induced superstructure and PP crystallinity degree are preserved. The presence of PP/PE copolymer + PE blend only in fabric P has been pointed out and PE content has been calculated. POLYM. ENG. SCI., 56:727–734, 2016. © 2016 Society of Plastics Engineers 相似文献
50.
Chiara Paolini Silvia Agarbati Devis Benfaremo Matteo Mozzicafreddo Silvia Svegliati Gianluca Moroncini 《International journal of molecular sciences》2022,23(7)
Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue characterized by vascular alterations, immune/inflammatory manifestations, and organ fibrosis. SSc pathogenesis is complex and still poorly understood. Therefore, effective therapies are lacking and remain nonspecific and limited to disease symptoms. In the last few years, many molecular and cellular mediators of SSc fibrosis have been described, providing new potential options for targeted therapies. In this review: (i) we focused on the PDGF/PDGFR pathway as key signaling molecules in the development of tissue fibrosis; (ii) we highlighted the possible role of stimulatory anti-PDGFRα autoantibodies in the pathogenesis of SSc; (iii) we reported the most promising PDGF/PDGFR targeting therapies. 相似文献