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91.
Maria Chiara Mistretta Luigi Botta Francesco Paolo La Mantia Antonino Di Fiore Marco Cascone 《大分子材料与工程》2021,306(9):2100177
Films for agricultural applications, such as greenhouses films or mulching films are generally made of polyolefins such as linear low-density polyethylene (LLDPE) or low-density polyethylene. However, the use of biodegradable and/or compostable polymers is increasing, which enjoy the additional advantage that they can be left on the site since a fine life would be gradually assimilated to the underlying soil. Nevertheless, biodegradable polymeric films often do not have suitable mechanical performances. In this work, biodegradable polymer-based nanocomposite films are prepared by film blowing and compared with traditional LLDPE based nanocomposites. In particular, a biodegradable polymer blend and two different inorganic nanofillers (an organo-modified clay and a calcium carbonate with a hydrophobic coating) are used for the preparation of the nanocomposites. A detailed investigation of obtained materials is performed through rheological, mechanical, and optical characterizations. Adding nanofillers led to an increase of rigidity and tear strength of blown films without negatively affecting their ductility. 相似文献
92.
Vincenzo De Leo Anna Maria Maurelli Chiara Ingrosso Fabio Lupone Lucia Catucci 《International journal of molecular sciences》2021,22(21)
Mussel-inspired chemistry was usefully exploited here with the aim of developing a high-efficiency, environmentally friendly material for water remediation. A micro-structured material based on polydopamine (PDA) was obtained by using liposomes as templating agents and was used for the first time as an adsorbent material for the removal of methylene blue (MB) dye from aqueous solutions. Phospholipid liposomes were made by extrusion and coated with PDA by self-polymerization of dopamine under simple and mild conditions. The obtained Liposome@PDA microspheres were characterized by DLS and Zeta potential analysis, TEM microscopy, and FTIR spectroscopy. The effects of pH, temperature, MB concentration, amount of Liposome@PDA, and contact time on the adsorption process were investigated. Results showed that the highest adsorption capacity was obtained in weakly alkaline conditions (pH = 8.0) and that it could reach up to 395.4 mg g−1 at 298 K. In addition, adsorption kinetics showed that the adsorption behavior fits a pseudo-second-order kinetic model well. The equilibrium adsorption data, instead, were well described by Langmuir isotherm. Thermodynamic analysis demonstrated that the adsorption process was endothermic and spontaneous (ΔG0 = −12.55 kJ mol−1, ΔH0 = 13.37 kJ mol−1) in the investigated experimental conditions. Finally, the applicability of Liposome@PDA microspheres to model wastewater and the excellent reusability after regeneration by removing MB were demonstrated. 相似文献
93.
Inside Cover: Looking for Efficient G‐Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug‐Like Molecules (ChemMedChem 4/2015) 下载免费PDF全文
94.
Dr. Nicola d'Avanzo Dr. Maria Chiara Cristiano Prof. Luisa Di Marzio Maria Chiara Bruno Prof. Donatella Paolino Prof. Christian Celia Prof. Massimo Fresta 《ChemMedChem》2022,17(9):e202200067
The use of proper nanocarriers for dermal and transdermal delivery of anti-inflammatory drugs recently gained several attentions in the scientific community because they pass intact and accumulate payloads in the deepest layers of skin tissue. Ascorbyl palmitate-based vesicles (aspasomes) can be considered a promising nanocarrier for dermal and transdermal delivery due to their skin whitening properties and suitable delivery of payloads through the skin. The aim of this study was the synthesis of multidrug Idebenone/naproxen co-loaded aspasomes for the development of an effective anti-inflammatory nanomedicine. Aspasomes had suitable physicochemical properties and were safe in vivo if topically applied on human healthy volunteers. Idebenone/naproxen co-loaded aspasomes demonstrated an increased therapeutic efficacy of payloads compared to the commercially available Naprosyn® gel, with a rapid decrease of chemical-induced erythema on human volunteers. These promising results strongly suggested a potential application of Idebenone/naproxen multidrug aspasomes for the development of an effective skin anti-inflammatory therapy. 相似文献
95.
Chemical modifications of Tonda Gentile Trilobata hazelnut and derived processing products under different infrared and hot‐air roasting conditions: a combined analytical study 下载免费PDF全文
96.
Roberta Squecco Alessia Tani Flaminia Chellini Rachele Garella Eglantina Idrizaj Irene Rosa Sandra Zecchi-Orlandini Mirko Manetti Chiara Sassoli 《International journal of molecular sciences》2021,22(7)
Bone marrow-mesenchymal stem/stromal cells (MSCs) may offer promise for skeletal muscle repair/regeneration. Growing evidence suggests that the mechanisms underpinning the beneficial effects of such cells in muscle tissue reside in their ability to secrete bioactive molecules (secretome) with multiple actions. Hence, we examined the effects of MSC secretome as conditioned medium (MSC-CM) on ex vivo murine extensor digitorum longus muscle injured by forced eccentric contraction (EC). By combining morphological (light and confocal laser scanning microscopies) and electrophysiological analyses we demonstrated the capability of MSC-CM to attenuate EC-induced tissue structural damages and sarcolemnic functional properties’ modifications. MSC-CM was effective in protecting myofibers from apoptosis, as suggested by a reduced expression of pro-apoptotic markers, cytochrome c and activated caspase-3, along with an increase in the expression of pro-survival AKT factor. Notably, MSC-CM also reduced the EC-induced tissue redistribution and extension of telocytes/CD34+ stromal cells, distinctive cells proposed to play a “nursing” role for the muscle resident myogenic satellite cells (SCs), regarded as the main players of regeneration. Moreover, it affected SC functionality likely contributing to replenishment of the SC reservoir. This study provides the necessary groundwork for further investigation of the effects of MSC secretome in the setting of skeletal muscle injury and regenerative medicine. 相似文献
97.
Fabio Maria Sabbatini Dr. Romano Di Fabio Dr. Mauro Corsi Dr. Paolo Cavanni Dr. Steve M. Bromidge Dr. Yves St‐Denis Dr. Lucilla D'Adamo Dr. Marilisa Rinaldi Dr. Chiara Savoia Dr. Claudia Mundi Dr. Benedetta Perini Dr. Andrew J. Carpenter Dr. Giovanna Dal Forno Dr. Federico Faggioni Dr. Michela Tessari Dr. Francesca Pavone Dr. Alberto Buson Dr. Mario Mattioli Dr. Elisabetta Perdona' Dr. Sergio Melotto Dr. 《ChemMedChem》2010,5(9):1450-1455
98.
Carlo Beatrice Chiara Guido Pierpaolo Napolitano Silvana Di Iorio Nicola Del Giacomo 《Fuel》2011,90(5):2039-2044
Results of a research project aimed at studying the capability to develop a method (economic and simple) for on-board biodiesel blending detection are described. The method is based on the direct measurement of the Indicated Mean Effective Pressure (IMEP).The study was carried out on a 2.0L four-cylinder “torque-controlled” Euro 5 diesel engine for passenger car (PC) application. This engine, equipped with instrumented glow plug for combustion closed-loop control, represents the state of the art of the diesel engine control technology.Two biodiesels were chosen for the experiments: a rapeseed methyl-ester (RME) and an aged RME, while the conventional diesel fuel was an European (EU) certification diesel fuel.Results indicate generally a good response in blending detection of the method. However, in order to attain an acceptable accuracy, a pre-calibration appears necessary. 相似文献
99.
Paolo Sarti Maria Chiara Magnifico Fabio Altieri Daniela Mastronicola Marzia Arese 《International journal of molecular sciences》2013,14(6):11259-11276
Extending our previous observations, we have shown on HaCat cells that melatonin, at ~10−9 M concentration, transiently raises not only the expression of the neuronal nitric oxide synthase (nNOS) mRNA, but also the nNOS protein synthesis and the nitric oxide oxidation products, nitrite and nitrate. Interestingly, from the cell bioenergetic point of view, the activated NO-related chemistry induces a mild decrease of the oxidative phosphorylation (OXPHOS) efficiency, paralleled by a depression of the mitochondrial membrane potential. The OXPHOS depression is apparently balanced by glycolysis. The mitochondrial effects described have been detected only at nanomolar concentration of melatonin and within a time window of a few hours’ incubation; both findings compatible with the melatonin circadian cycle. 相似文献
100.