In the context of the ITER contract “ITER/CT/07/219–200 kV Stored Energy Tests”, electrical breakdown tests have been performed in vacuum with a stored energy of up to 425 J. The experiments have been conceived and performed with the collaboration of Consorzio RFX. The tests are being performed in the 1 MV test facility at IRFM, CEA-Cadarache. They should simulate the conditions that will be found in the ITER Neutral Beam accelerator, at 200 kV. This paper presents the set-up of the test bed, the choice of critical components, the diagnostic equipments and the results obtained with 200 kV applied on the anode electrode. 相似文献
Melanoma is a complex and heterogenous disease, displays the deadliest form of skin cancer, and accounts for approx. 80% of all skin cancer deaths. In this study, we reported on the synthesis and pharmacological effects of a novel shikonin derivative (SK119), which is active in a nano-molar range and exhibits several promising in vitro effects in different human melanoma cells. SK119 was synthesized from shikonin as part of our search for novel, promising shikonin derivatives. It was screened against a panel of melanoma and non-tumorigenic cell lines using XTT viability assays. Moreover, we studied its pharmacological effects using apoptosis and Western blot experiments. Finally, it was combined with current clinically used melanoma therapeutics. SK119 exhibited IC50 values in a nano-molar range, induced apoptosis and led to a dose-dependent increase in the expression and protein phosphorylation of HSP27 and HSP90 in WM9 and MUG-Mel 2 cells. Combinatorial treatment, which is highly recommended in melanoma, revealed the synergistic effects of SK119 with vemurafenib and cobimetinib. SK119 treatment changed the expression levels of apoptosis genes and death receptor expression and exhibited synergistic effects with vemurafenib and cobimetinib in human melanoma cells. Further research indicates a promising potential in melanoma therapy. 相似文献
Scientometrics - Identification of important works and assessment of importance of publications in vast scientific corpora are challenging yet common tasks subjected by many research projects.... 相似文献
Many commonly well-performing convolutional neural network models have shown to be susceptible to input data perturbations, indicating a low model robustness. To reveal model weaknesses, adversarial attacks are specifically optimized to generate small, barely perceivable image perturbations that flip the model prediction. Robustness against attacks can be gained by using adversarial examples during training, which in most cases reduces the measurable model attackability. Unfortunately, this technique can lead to robust overfitting, which results in non-robust models. In this paper, we analyze adversarially trained, robust models in the context of a specific network operation, the downsampling layer, and provide evidence that robust models have learned to downsample more accurately and suffer significantly less from downsampling artifacts, aka. aliasing, than baseline models. In the case of robust overfitting, we observe a strong increase in aliasing and propose a novel early stopping approach based on the measurement of aliasing.
The sterol composition of free sterol and steryl ester fractions of the fish parasiteParatenuisentis ambiguus was determined. In addition, the fatty acid composition of various neutral lipid classes, i.e., wax esters, steryl esters,
triacylglycerols and free fatty acids, as well as the composition of the 1-O-alkyl moieties of total ether glycerolipids of the parasite, were investigated. The results of these studies were compared
with those obtained on the intestinal tract tissue of its host, the eel (Anguilla anguilla). Cholesterol is the major sterol in bothP. ambiguus andA. anguilla. However, the sterols ofP. ambiguus contain high proportions (>20%) of other sterols, such as campesterol and various dehydrosterols. [e.g., 7-dehydrocholesterol
and cholesta-5,22(E)-dienol]. The presence of these minor sterols agrees with the known biotransformations of exogenous sterols in various helminths.
Considerable differences are found in the fatty acid composition of neutral lipid fractions, as well as the total lipid extract
from the endoparasite as compared to the host tissue. In particular, eicosapentaenoic acid (20∶5n−3), other polyunsaturated
fatty acids, such as 20∶4n−6, 22∶5n−3 and 22∶6n−3, as well as long-chain saturated fatty acids, such as 20∶0, are generally
enriched in the neutral lipid fractions of the parasite as compared to those of infected eel intestine. The analysis of ether
glycerolipids revealed that 1-O-hexadecyl (16∶0) and 1-O-hexadecenyl (16∶1) moieties were present in similar proportions in the ether lipids of bothP. ambiguus and eel intestine, whereas 1-O-octadecyl (18∶0) moieties are more prominent in the parasite and 1-O-octadecenyl (18∶1) moieties in the eel. The results of these studies show thatP. ambiguus has specific mechanisms for the regulation of the sterol and fatty acid composition of its neutral lipids.
Dedicated to Professor Helmut K. Mangold on the occasion of his 70th birthday. 相似文献
The current work intended to enhance our knowledge of changes or lack of changes in the speech signal when people were being deceptive. In particular, the study attempted to investigate the appropriateness of using speech cues in detecting deception. Truthful, deceptive and control speech were elicited from ten speakers in an interview setting. The data were subjected to acoustic analysis and results are presented on a range of speech parameters including fundamental frequency (f0), overall amplitude and mean vowel formants F1, F2 and F3. A significant correlation could not be established between deceptiveness/truthfulness and any of the acoustic features examined. Directions for future work are highlighted. 相似文献
Reputation systems are fundamental for assessing the quality of user contributions in participatory sensing. However, naively associating reputation scores to contributions allows adversaries to establish links between multiple contributions and thus de-anonymize users. We present the IncogniSense framework as a panacea to these privacy threats. IncogniSense utilizes periodic pseudonyms generated using blind signature and relies on reputation transfer between these pseudonyms. Simulations are used to analyze various reputation cloaking schemes that address the inherent trade-off between anonymity protection and loss in reputation. Our threat analysis confirms the robustness of IncogniSense and a prototype demonstrates that associated overheads are minimal. 相似文献
The archazolids are potent antiproliferative compounds that have recently emerged as a novel class of promising anticancer agents. Their complex macrolide structures and scarce natural supply make the development of more readily available analogues highly important. Herein, we report the design, synthesis and biological evaluation of four simplified and partially saturated archazolid derivatives. We also reveal important structure-activity relationship data as well as insights into the pharmacophore of these complex polyketides. 相似文献