Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a complex process involving not only intravasation of tumor cells from the primary tumor into circulation, but extravasation from circulation into the bone where they meet an environment that is generally suppressive of their growth. The bone microenvironment can inhibit the growth of disseminated tumor cells (DTC) by inducing dormancy of the DTC directly and later on following formation of a micrometastatic tumour mass by inhibiting metastatic processes including angiogenesis, bone remodeling and immunosuppressive cell functions. In this review we will highlight some of the mechanisms mediating DTC dormancy and the complex relationships which occur between tumor cells and bone resident cells in the bone metastatic microenvironment. These inter-cellular interactions may be important targets to consider for development of novel effective therapies for the prevention or treatment of bone metastases.     

Size distribution functions of dispersions

The size distribution function of bubbles in thermodynamic equilibrium with the surrounding liquid has been derived in the absence of gravity. The derivation has been based on the assumption that the gas is dispersed into bubbles in a completely random way in respect of the energies of the bubbles. The size distribution function of bubbles obtained when surface tension effects are neglected is of the same form as the empirical Nukiyama-Tanasawa distribution, and gives also the size distribution function of droplets consisting of an incompressible liquid when the way the liquid is dispersed into droplets is assumed to be completely random with respect to the volumes of the droplets. The derived size distribution functions agree well with the experimental size distributions of bubbles in water having been generated by an air entrainment process at the surface of the water or behind a ventilated body.     

Adaptive signal processing of asset price dynamics with predictability analysis

In this paper we illustrate the optimal filtering of log returns of commodity prices in which both the mean and volatility are modulated by a hidden Markov chain with finite state space. The optimal estimate of the Markov chain and the parameters of the price model are given in terms of discrete-time recursive filters. We provide an application on a set of high frequency gold price data for the period 1973-2006 and analyse the h-step ahead price predictions against the Diebold-Kilian metric. Within the modelling framework where the mean and volatility are switching regimes, our findings suggest that a two-state hidden Markov model is sufficient to describe the dynamics of the data and the gold price is predictable up to a certain extent in the short term but almost impossible to predict in the long term. The proposed model is also benchmarked with ARCH and GARCH models with respect to price predictability and forecasting errors.     

Institutional pressures and mindful IT management: The case of a container terminal in China

Although it has been only ten years in operations, Yantian International Container Terminals Limited (YICT) has evolved as a world-class container terminal and become the first Chinese port to receive the Best Global Container Port of the Year award for 2005–2006, as well as being designated China's best container terminal in terms of operational efficiency for 2008. A success factor of YICT is its extensive use of IT in managing and enhancing the productivity and services of the port operations. Premised upon Institutional Theory and the organizational mindfulness perspectives (preoccupation with failure and success, reluctance to simplify interpretations, sensitivity to operations, commitment to resilience, and reliance on expertise over formal authority) and using case study methodology, we examined the institutional pressures faced by YICT in its IT management (ITM), and determined how YICT coped with its institutional pressures during its IT development.     

A Glance into Social and Evolutionary Aspects of an Artifact Ecology for Collaborative Learning through the Lens of Distributed Cognition

There is steadily growing interest in the design and evaluation of digitally enhanced spaces in the real-world where users use, combine, and appropriate different physical and digital tools based on the task at hand. Under the notion of “ubiquitous computing,” researchers have explored tools and theories to analyze, understand, and model users in complex socio-technical systems. Yet, even though theoretical approaches play a significant role in the work of practitioners, there is a general difficulty in applying them, pushing researchers to explore methodological frameworks with clearer guidelines. Using the distributed cognition for teamwork (DiCoT) framework, we study collaboration and communication patterns, physical movement, and social structures of two groups of learners working on a design problem as they evolve over a 3-month period. Through an in-depth investigation, we present detailed accounts of the social and evolutionary models of DiCoT for each group. Our analysis enriches the DiCoT framework by identifying five new principles: social emersion and social circles of privacy for the social model, and continuity, mutual adaptation, and semantics of body for the evolutionary model. This article contributes to HCI research by refining and extending the existing DiCoT framework and elaborating on two dimensions that have previously been under-developed in the literature.     

An intervention method for occupational safety in farming -- evaluation of the effect and process

In order to increase safety in Swedish farming an intervention methodology to influence attitudes and behaviour was tested. Eighty eight farmers and farm workers in nine groups gathered on seven occasions during 1 year. The basic concept was to create socially supportive networks and encourage discussions and reflection, focusing on risk manageability. Six of the groups made structured incident/accident analyses. Three of the latter groups also received information on risks and accident consequences. Effects were evaluated in a pre-post questionnaire using six-graded scales. A significant increase in safety activity and significant reduction in stress and risk acceptance was observed in the total sample. Risk perception and perceived risk manageability did not change. Analysing incidents/accidents, but not receiving information, showed a more positive outcome. Qualitative data indicated good feasibility and that the long duration of the intervention was perceived as necessary. The socially supportive network was reported as beneficial for the change process.     

The implications of cross-regional differences for the design of In-vehicle Information Systems: a comparison of Australian and Chinese drivers

The increasing global distribution of automobiles necessitates that the design of In-vehicle Information Systems (IVIS) is appropriate for the regions to which they are being exported. Differences between regions such as culture, environment and traffic context can influence the needs, usability and acceptance of IVIS. This paper describes two studies aimed at identifying regional differences in IVIS design needs and preferences across drivers from Australia and China to determine the impact of any differences on IVIS design. Using a questionnaire and interaction clinics, the influence of cultural values and driving patterns on drivers' preferences for, and comprehension of, surface- and interaction-level aspects of IVIS interfaces was explored. Similarities and differences were found between the two regional groups in terms of preferences for IVIS input control types and labels and in the comprehension of IVIS functions. Specifically, Chinese drivers preferred symbols and Chinese characters over English words and were less successful (compared to Australians) at comprehending English abbreviations, particularly for complex IVIS functions. Implications in terms of the current trend to introduce Western-styled interfaces into other regions with little or no adaptation are discussed.